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Vision in the European Focus

A review on corneal stromal stem cells

Professor Claus Cursiefen co-authored a review article that presents corneal stromal stem cells (CSSCs) as a new therapeutic target for corneal injuries and diseases. Corneal impairments are prominent causes of blindness. Since access to corneal transplantation is challenging, research may focus on...
» A review on corneal stromal stem cells

Modulating gap junction permeability in photoreceptor-degenerated retinas

Professor Eberhart Zrenner contributed to a research article that aims to understand the lateral gap junction (GJ)-mediated communication pathway in photoreceptor-degenerated retinas, which is crucial for effective treatment of functional disorders of neuronal membrane channels. GJs play a vital...
» Modulating gap junction permeability in photoreceptor-degenerated retinas

Sonogenetic for vision restoration

Professor Serge Picaud supervised a study that, for the first time, demonstrated the use of high-frequency ultrasonic stimulation after ectopic expression of a mechanosensitive ion channel of large conductance (MscL) to activate the visual cortex. MscL was expressed in vivo in both rat retinal...
» Sonogenetic for vision restoration

Toward a virtual human retinal organoid

Professor Hendrik Scholl co-authored a Nature Biotechnology publication. The study characterized retinal organoids by integrating iterative indirect immunofluorescence imaging with a computational approach, dense single-cell RNA sequencing, and a single-cell assay for transposase-accessible...
» Toward a virtual human retinal organoid

An overview of the imaging modalities and criteria used to characterize fibrosis in nAMD

Professor Sascha Fauser supervised a review article presenting the imaging modalities and criteria currently used to detect and quantify fibrosis in neovascular age-related macular degeneration (nAMD). The study reveals significant heterogeneity in the current characterization of fibrosis. Most...
» An overview of the imaging modalities and criteria used to characterize fibrosis in nAMD

Serum biomarkers for retinal neurodysfunction

Professor José Cunha-Vaz, a member of the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR), contributed to a study evaluating the utility of serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in identifying and monitoring retinal...
» Serum biomarkers for retinal neurodysfunction

A review on clinical management options for patients with RP

Professor Camiel J. F. Bonn supervised a review article presenting the currently available options to manage retinitis pigmentosa (RP). RP causes a gradual loss of visual function due to the degeneration of photoreceptors, with an individual-specific clinical course that is hard to predict. Although...
» A review on clinical management options for patients with RP

Artificial Intelligence (AI) in ophthalmic diagnostics

Professor Francesca M. Cordeiro co-authored a publication presenting a fully automated algorithm which, based on OCT images, can detect and quantify all six features of macular atrophy in wet AMD – namely: interrupted outer retina, interrupted retinal pigment epithelium, absence of outer retina,...
» Artificial Intelligence (AI) in ophthalmic diagnostics

Mireca signs transformative deal with Nasdaq-listed Graybug Vision

Mireca’s proprietary cyclic guanosine monophosphate (cGMP) analogues to be developed using Graybug’s sustained-release drug delivery technologies. The partnership is exclusive for the development of products targeting eye and ear disorders. Mireca will invest proceeds to develop the cGMP analogues...
» Mireca signs transformative deal with Nasdaq-listed Graybug Vision

The algebra of neurons

Neurons are constantly performing complex calculations to process sensory information and infer the state of the environment. For example, to localize a sound or to recognize the direction of visual motion, individual neurons are thought to multiply two signals. However, how such a computation is...
» The algebra of neurons