Prof. Christian Grimm is principal investigator and group leader of the lab of Retinal Cell Biology at the University of Zurich, Switzerland.
Our research aims at the understanding of the pathophysiology of retinal degenerations. This provides the basis for the interference with death pathways and/or the support of endogenous survival mechanisms to protect visual cells and to prolong the period of useful vision for patients.
- Association for Research in Vision and Ophthalmology (ARVO)
- Swiss Society for Ophthalmology (SOG)
Research Group
Lab for Retinal Cell Biology
Key Publications
- Thiersch, M., Raffelsberger, W., Frigg, R., Samardzija, M., Wenzel, A., Poch, O., Grimm, C (2008)
Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.
BMC Genomics, 9:73 - Samardzija M., Wenzel A., Aufenberg, S., Thiersch, M., Remé, C., Grimm C (2006)
Differential role of Jak-STAT signaling in retinal degenerations.
FASEB J. 20:E1790-E1801. - Grimm C., Wenzel A., Stanescu D., Samardzjia M., Hotop S., Groszer M., Naash M., Gassmann M., Remé C.E. (2004)
Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration.
J Neurosci. 24:5651-5658 - Grimm C., Wenzel A., Groszer M., Mayser, H., Seeliger, M., Samardzija, M., Bauer, C., Gassmann M., Remé C.E. (2002)
HIF-1 – induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration.
Nature Med. 8: 718-724. - Seeliger M., Grimm C., Stahlberg F., Friedburg C., Jaissle G., Zrenner E., Gao H., Remé C.E., Humphries P., Hofmann F., Biel M., Fariss R.N., Redmond T.M., Wenzel A. (2001)
New views onRPE65 deficiency: The rod system is the source of vision in a mouse model of Lebers congenital amaurosis.
Nature Genetics. 29: 70-74
- Grimm C., Wenzel A., Behrens A., Hafezi F., Wagner E.F., Remé C.E. (2001)
AP–1 mediated retinal photoreceptor apoptosis is independent of the JNK-pathway.
Cell Death Differ. 8: 859-867
- Wenzel A., Remé C.E., Williams T.P., Hafezi F., Grimm C. (2001)
The Rpe65 Leu450Met mutation increases retinal resistance against light–induced degeneration by slowing rhodopsin regeneration.
J. Neurosci. 21: 53–58
- Grimm C., Wenzel A., Hafezi F., Remé C.E. (2000)
Gene expression in the mouse retina: The effect of damaging light.
Mol. Vis. 6: 252–260
- Grimm C., Wenzel A., Hafezi F., Yu S., Redmond T.M., Remé C.E. (2000)
Protection of Rpe65–deficient mice identifies rhodopsin as mediator of light–induced retinal degeneration.
Nature Genet. 25: 63–66
- Wenzel A., Grimm C., Marti A., Kueng-Hitz N., Hafezi F., Niemeyer G., Remé C.E. (2000)
c–Fos controls the ‘private pathway’ of light–induced apoptosis of retinal photoreceptors.
J. Neurosci. 20: 81–88
Research Groups
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