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My lab explores the functional properties of mammalian rod and cone photoreceptors using the mouse retina as a model system. Our current focus is on the strength and regulatory potential of connexin–mediated electrical coupling between rods and cones, which we investigate by peforming patch–clamp recordings from single mouse cones. Using this technique we are able to compare light responses and membrane currents of the same neuron in different mouse strains, as well as observe the changes evoked by acute pharmacological manipulation.
Lorenzo Cangiano
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Dip. di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia
Via San Zeno 31
56123 Pisa
Italy
Phone: +390502213498
FAX: +390502213527