Current Research Projects
My research focuses on the molecular mechanism of photoreceptor degeneration with the goal of identifying new markers and therapeutic targets. I am involved in the preclinical developments of drugs for inherited photoreceptor degeneration (www.drugsford.eu).
I am also interested in the role of poly (ADP-ribose) polymerase (PARP) and poly (ADP-ribose) glycohydrolase (PARG) in retinal degeneration.
Methodology
- In vivo injection methods (intravitreal, intraperitoneal, intravenous, subcutaneous)
- Organotypic retinal culture
- Western blot
- Immunofluorescence, immunohistochemistry
- in situ biochemical assays
Ayse Sahaboglu |
Research Group
Division of Experimental Ophthalmology
Selected Publications
- Sahaboglu A, Tanimoto N, Bolz B, Garcia Garrido M, Ueffing M, Seeliger MW, Löwenheim H, Ekström P, Paquet-Durand F. (2014)
Knockout of PARG110 confers resistance to cGMP induced toxicity in mammalian photoreceptors.
Cell Death and Disease. doi: 10.1038/cddis.2014.208. - Sahaboglu A, Bolz S, Lowenheim H, Paquet-Durand F (2014)
Expression of Poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.
Adv Exp Med Biol. doi: 10.1007/978-1-4614-3209-8_59. - Paquet-Durand F, Sahaboglu A, Dietter J, Paquet-Durand O, Hitzmann B, Ueffing M, Ekström P (2014)
How long does a photoreceptor cell take to die? Implications for the causative cell death mechanisms.
Adv Exp Med Biol. Doi:10.1007/978-1-4614-3209-8_73. - Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB. (2013)
Inhibition of mitochondrial pyruvate transport by Zaprinast causes massive accumulation of aspartate at the expense of glutamate in retinas.
The Journal of Biological Chemistry. Doi: 10.1074/jbc.M113.507285 - Sahaboglu A, Paquet-Durand O, Dengler K, Bernhard-Kurz S, Hitzmann B, Ueffing M, Paquet-Durand F. (2013)
Retinitis Pigmentosa: Rapid neurodegeneration is governed by slow cell death mechanisms.
Cell Death and Disease. doi:10.1038/cddis.2013.12 - Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F. (2012)
Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration.
Curr Mol Med. 12(5):598-612. - Kaur J, Mencl S, Sahaboglu A, van Veen T, Zrenner E, Ekstrom P, Paquet Durand F, Arango-Gonzalez B. (2011)
Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats.
PLoS ONE. 6 (7):e22181. - Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F. (2010)
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
PLoS ONE 5(11): e15495. - Sancho-Pelluz J, Alavi M, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P. (2010)
Excessive HDAC activation critical for neurodegeneration in the rd1 mouse.
Cell Death & Disease, doi:10.1038/cddis.2010.4. - Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz, A, Paquet-Durand F, Wenzel A, Seeliger MW, Fischer MD. (2009)
Spectral domain optical coherence tomography in mouse models of retinal degeneration.
Investigative Ophthalmology & Visual Science 50(12):5888-5995. - Dilsiz N, Sahaboglu A, Yıldız MZ, and Reichenbach A. (2006)
Protective effects of various antioxidants during ischemia-reperfusion in the rat retina.
Graefe’s Archive for Clinical and Experimental Ophthalmology 244 (5): 627-633.
Research Groups
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