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Division of Ocular Neurodegeneration

Our mission is to uncover the pathophysiology of ocular neurodegenerative processes, to develop and test therapeutic strategies, and to understand and model normal retinal function. The basis of our work is in-depth functional and morphological phenotyping of genetic models of blinding human neurodegenerative disorders with electroretinography (ERG), scanning-laser ophthalmoscopy (SLO), and optical coherence tomography (OCT), the same non-invasive techniques used in affected patients.


  • Electroretinographic (ERG) techniques
  • Scanning-laser ophthalmoscopy (SLO) in vivo imaging
  • Optic coherence tomography (OCT) in vivo imaging

Scientific Cooperations

  • Cooperation 1:
    Martin Biel, Munich
  • Cooperation 2:
    Pete Humphries, Dublin
  • Cooperation 3:
    Jan Wijnholds, Amsterdam
  • Cooperation 4:
    Christian Grimm, Zurich
  • Cooperation 5:
    Laura Frishman, Houston

Group Leader

Mathias Seeliger
[more information]


University of Tuebingen
Centre for Ophthalmology
Institute for Ophthalmic Research

Schleichstrasse 4/3
72076 Tuebingen

Phone: +49-7071-2980718
Fax: +49-7071-294789



Current Research Projects

  • Project 1:
    Neurodegeneration research: Investigation of the causes of and the disease mechanisms in retinal degenerations based on animal models with homologous genetic defects to human patients.
  • Project 2:
    Molecular therapy: Development of optimal application procedures and the evaluation of the therapeutic success by short- and long-term follow-up in vivo.
  • Project 3:
    Methodological innovation and refinement:  Development and refinement of innovative diagnostic strategies in human patients and animal models.
  • Project 4:
    Systems biology: Assessment of functional pathways, particularly in the outer retina, by means of mouse lines with specific genetic defects in photoreceptor function and/or connectivity.

Research Groups