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Andrew John Lotery

Scientifc Interest

  • Genetics of ARMD
  • Genetics of glaucoma
  • Genetics of nystagmus
  • Stem cells for retinal / macular disease


  • Association for Research in Vision and Ophthalmology (ARVO)
  • Macula Society
  • British Eye Research Group
  • Senior Investigator, National Institute Health Research

Key Publications

  1. Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A et al.
    Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
    Lancet 2008 October 6.
  2. Goverdhan SV, Khakoo SI, Gaston H, Chen X, Lotery A.
    Age related macular degeneration is associated with the HLA Cw*0701 genotype and the Natural Killer cell receptor AA haplotype.
    Invest Ophthalmol Vis Sci 2008 May 30.
  3. Ennis S, Goverdhan S, Cree A, Hoh J, Collins A, Lotery A.
    Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region.
    British Journal of Ophthalmology 2007 July 1;91(7):966-70.
  4. Lotery AJ, Baas D, Ridley C, Jones RP, Klaver CC, Stone E et al.
    Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa.
    Hum Mutat 2006 June;27(6):568-74.
  5. Goverdhan SV, Howell MW, Mullins RF, Osmond C, Hodgkins PR, Self J et al.
    Association of HLA class I and class II polymorphisms with age-related macular degeneration.
    Invest Ophthalmol Vis Sci 2005 May;46(5):1726-34.
  6. Stone EM, Braun TA, Russell SR, Kuehn MH, Lotery AJ, Moore PA et al.
    Missense variations in the fibulin 5 gene and age-related macular degeneration.
    N Engl J Med 2004 July 22;351(4):346-53.
  7. Guymer RH, Heon E, Lotery AJ, Munier FL, Schorderet DF, Baird PN et al.
    Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration.
    Arch Ophthalmol 2001 May;119(5):745-51.
  8. Lotery AJ, Jacobson SG, Fishman GA, Weleber RG, Fulton AB, Namperumalsamy P et al.
    Mutations in the CRB1 gene cause Leber congenital amaurosis.
    Arch Ophthalmol 2001 March;119(3):415-20.
  9. Stone EM, Lotery AJ, Munier FL, Heon E, Piguet B, Guymer RH et al.
    A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy.
    Nat Genet 1999;22(2):199-202.
  10. Stone EM, Webster AR, Vandenburgh K, Streb LM, Hockey RR, Lotery AJ et al.
    Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration.
    Nat Genet 1998 December;20(4):328-9.
Andrew John Lotery
Andrew John Lotery

Research Group

Laboratory of Cellular and Molecular Pathophysiology of the Retina

Analysis of molecular mechanisms involved in retinal progenitor cell differentiation


Southampton General Hospital

LD74, MP806
Clinical Neurosciences
South Lab & Path Block

SO16 6YD Southampton
United Kingdom

Phone: +44 (0) 23 8079 4590
Fax: +44 (0) 23 80794264/4542



Research Groups