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Martine J. Jager

Short CV

Dr. Martine J. Jager is head of the Laboratory of Ophthalmology at Leiden University, The Netherlands.

Her research interests are immunology and development of uveal melanoma and ocular surface diseases. She received her PhD in immunology from Leiden University, did her residency in Ophthalmology at the University of Amsterdam, and a clinical fellowship at the Bascom Palmer Eye Institute in Miami. She is a frequent visitor at the Schepens Eye Research institute, Boston, where she holds a position as adjunct scientist. She mentors medical and PhD students, in the Netherlands as well as abroad.

Dr. Jager is Board member of the International Society of Ocular Oncology (ISOO), and of the European Association for vision and Eye Research (EVER), past-President of the Association for Research in Vision and Ophthalmology (ARVO), and member of the Advisory Board of the International Council of Ophthalmology. As past-president of ARVO, she is active in developing ARVO Chapters to stimulate eye research world-wide. She participates as reviewer and member of the Editorial Board in several ophthalmological journals, including Investigative Ophthalmology and Visual Science.

Scientifc Interest

  • Ocular oncology
  • Immunology of the eye
  • Herpes infections
  • Corneal transplantation


  • Association for Research in Vision and Ophthalmology (ARVO)
  • EVER
  • AAO
  • NOG

Further Activities

  • Board member and past-president ARVO
  • Board member EVER
  • Board member International Society of Ocular Oncology
  • Member of the Advisory Board of the International Council of Ophthalmology
  • Member Editorial Board Investigative Ophthalmology visual Science
Martine J. Jager
Martine J. Jager

Research Group

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Leiden University Medical Centre

PO Box 9600
2300 RC Leiden
The Netherlands

Phone: 31-71-5262097
Fax: 31-71-5248222


Key Publications

  1. Jager M.J., Klaver C.C.
    Macrophages feel their age in macular degeneration.
    J Clin Invest 2007; 117: 3182-3184
  2. Maat W., Jordanova E.S., van Zelderen-Bhola S.L., Barthen E.R., Wessels H.J.W., Schalij-Delfos N.E., Jager M.J.
    The heterogeneous distribution of monosomy 3 in uveal melanoma; Implications for prognostication based on Fine-Needle Aspiration Biopsies.
    Arch Pathol Lab Med 2007, 131, 91-96
  3. Maat W., van der Velden P.A., Out-Luiting C, Plug M, Dirks-Mulder A, Jager M.J., Gruis N.A.
    Epigenetic inactivation of RASSF1a in uveal melanoma.
    Invest. Ophthalmol. Vis. Sci. 2007, 48, 486-490
  4. Maat W., Beiboer S.H.W., Jager M.J., Luyten G.P.M., Gruis N.A., Van der Velden P.A.
    Epigenetic regulation identifies RASEF as a tumor suppressor gene in uveal melanoma.
    Invest Ophthalmol Vis Sci. 2008; 49, 1291-1298.
  5. Maat W., Ly L.V., Jordanova E.S., Wolff-Rouendaal D. de, Schalij-Delfos N.E., Jager M.J.
    Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma.
    Invest Ophthalmol Vis Sci 2008; 49: 505-510
  6. Hallermalm K., Seki K., De Geer A., Motyka B., Bleackley R.C., Jager M.J., Frohlich C.J., Levitsky V, Levitskaya J.
    Modulation of the tumor cell phenotype by IFN gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
    J Immunol. 2008; 180: 3766-3774.
  7. Keijser S., Jager M.J., Dogterom-Ballering H.C.M., Schoonderwoerd D.T.,. de Keizer R.J.W,. Krose C.J.M, Houwing-Duistermaat J.J., van der Plas M.J.A., van Dissel J.T., Nibbering P.H.
    Lactoferrin Glu561Asp polymorphism is associated with susceptibility to herpes simplex keratitis.
    Exp Eye Res 2008; 86, 105-109.
  8. El Filali M, Homminga I., Maat W., Van der Velden P.A., Jager M.J.
    Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth.
    Molecular Vision 2008; 14: 1752-1759
  9. Keijser S., Kurreeman F.A.S., De Keizer R.J.W., Dogterom-Ballering H., Van der Lelij A., Jager M.J., Nibbering P.H.
    IL-10 promotor haplotypes associated with susceptibility to and severity of bacterial corneal ulcers.
    Exp. Eye Res. 2009 in press
  10. Polak M.E., Borthwick N.J., Jager M.J., Cree I.A.
    Melanoma vaccines- the problem of local immunosuppression.
    Human Immunology 2009 in press.

Research Groups