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Florian Sennlaub

Short CV

Florian Sennlaub obtained his MD in Germany before receiving his PhD at the University René Descartes in Paris for his work on the role of iNOS in ocular neovascularization.  

He then went on to study the mediators of microvascular degeneration in Dr Sylvain Chemtob’s Laboratory in Montreal. He currently directs his own research team at the French National Institut of Health Research (Inserm).

His laboratory, at the Centre de Recherche de Cordeliers in the heart of Paris, focuses on the molecular mechanisms of age-related macular degeneration. His research is supported by grants from the French national research agency (ANR).

Dr. Sennlaub is a recipient of the prestigious European Council Starting Grant.


CV of Florian Sennlaub [pdf]

Scientifc Interest

  • Microvascular and neuronal degeneration
  • Neovascularization


  • American Society of Human Genetics (ASHG)
  • Club d’Angiogenèse
Florian Sennlaub
Florian Sennlaub

Research Group

Ocular degenerative and neovascular processes

[more information]


Institut de la Vision

17, rue Moreau
75012 Paris



Key Publications

  1. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F,
    The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
    Nat Med 2008.14(10):1067-76
  2. Lejmi E, Leconte L, Pédron-Mazoyer S, Ropert S, Raoul W, Lavalette S, Bouras I, Feron JG, Maitre-Boube M, Assayag F, Feumi C, Alemany M, Jie TX, Merkulova T, Poupon MF, Ruchoux MM, Tobelem G, Sennlaub F, Plouët J
    Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B
    Proc Natl Acad Sci U S A 2008.Aug 26;105(34):12491-6
  3. Houssier M, Raoul W, Lavalette S, Keller N, Guillonneau X, Baragatti B, Jonet L, Jeanny JC , Behar-Cohen F, Coceani F, Scherman D, Lachapelle P, Ong H, Chemtob S, Sennlaub F.
    CD36 Deficiency Leads to Choroidal Involution via COX-2 Downregulation.
    PLoS Medecine 2008.2008 Feb; 5(2):e39
  4. Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, Lavalette S, Houssier M, Jonet L, Picard E, Debré P, Sirinyan M, Deterre P, Ferroukhi T, Cohen S, Chauvaud D, Jeanny J, Chemtob S, Behar-Cohen F, Sennlaub F
    CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    J Clin Invest 2007.2007 Oct;117(10):2920-8
  5. Sennlaub F. (first co-author), E. Kermorvant-Duchemin, M. Sirinyan, S. Brault, G. Andelfinger, A. Kooli, S. Germain, H. Ong, P. d\'Orleans-Juste, F. Gobeil, T. Zhu, C. Boisvert, P. Hardy, K. Jain, J.R. Falck, M. Balazy, and S. Chemtob
    Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration.
    Nat Med 2005.2005 Dec;11(12):1339-45
  6. Sennlaub F, Valamanesh F, Vazquez-Tello A, El-Asrar AM, Checchin D, Brault S, Gobeil F, Beauchamp MH, Mwaikambo B, Courtois Y, Geboes K, Varma DR, Lachapelle P, Ong H, Behar-Cohen F, Chemtob S
    Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy
    Circulation 2003.2003 Jul 15;108(2):198-204

Research Groups