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Martin Biel

Short CV

Since 2009 Dean, Faculty of Chemistry and Pharmacy, LMU München
2007-2009 ViceDean, Faculty of Chemistry and Pharmacy, LMU München
1999 Professor (C4) and Chair of Pharmacology, Department of Pharmacy, LMU München
1991-1999 Research Assistant, Institute of Pharmacology and Toxicology, TU München
1990 Dr. rer.nat. , Saarland University
1988-1990 Research Assistant, Institute of Physiological Chemistry, Saarland University
1983-1998 Study of Pharmacy, Saarland University


CV of Martin Biel [pdf]

Scientifc Interest

  • Ion channel function in retinal circuits
  • Hyperpolarization-activated cation channels (HCN channels)
  • Genetic mouse models
  • Molecular basis of photoreceptor degeneration
  • Therapeutic rescue of retinal proteins via viral gene transfer
Martin Biel
Martin Biel

Research Group



Center for Integrated Protein Science Munich CIPSM and
Department of Pharmacy – Center for Drug Research

Butenandtstr. 5-1381377 MunichGermany

Phone: +49-89-2180-77327
Fax-Number: +49-89-2180-77326



Key Publications

  1. Griessmeier K, Cuny H, Rötzer K, Griesbeck O, Harz H, Biel M#, Wahl-Schott C.# (2009)
    Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels.
    J.Biol.Chem. 284:29809-29816
  2. Michalakis S, Reisert S, Geiger H, Wetzel C, Zong X, Bradley J, Spehr M, Hüttl S, Gerstner A, Pfeifer A, Hatt H, Yau KW, and Biel M (2006)
    Loss of CNGB1 protein leads to olfactory dysfunction and subciliary CNG channel trapping.
    J. Biol. Chem. 281:35156-35166
  3. Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M (2006)
    Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain.
    Proc. Acad. Sci. USA. 103:15657-15662
  4. Hüttl S, Michalakis S, Seeliger S, Luo D, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, Moser M, Pfeifer A, Gerstner A, Yau KW, Biel M (2005)
    Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
    J. Neurosci. 25:130-138
  5. Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH. Hankins MW, Lem J, Biel M , Hofmann F, Foster RG, Yau KW (2003)
    Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.
    Nature 424:75-81
  6. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. (2003)
    Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.
    EMBO J 15:216-224
  7. Seeliger M, Grimm C, Stahlberg F, Friedburg C, Jaissle G, Zrenner E, Guo H, Remé C, Humphries P, Hofmann F, Biel M, Fariss RN, Redmond TM, Wenzel A (2001)
    New views on RPE65 deficiency: The rod system is the source of vision in a mouse model of Lebers congenital amaurosis.
    Nature Genet 29:70-74
  8. Gerstner A, Zong X, Hofmann F, Biel M (2000)
    Molecular cloning and functional characterization of a new modulatory CNG channel subunit from mouse retina.
    J Neurosci 20:1324-1332
  9. Biel M, Seeliger M, Pfeifer A, Kohler K, Gerstner A, Ludwig A, Jaissle G, Fauser S, Zrenner E, Hofmann F. (1999)
    Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.
    Proc Natl Acad Sci USA 96:7553-7557
  10. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998)
    A family of hyperpolarization-activated mammalian cation channels.
    Nature 393:587-591

Research Groups