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James Bainbridge

Short CV

2011-Professor of Retinal Studies, UCL Institute of Ophthalmology
2007-Faculty Investigator, National Institute for Health Research
2007-Diabetes Theme Leader, NIHR Biomedical Research Centre
2005-10Wellcome Advanced Fellow, UCL Institute of Ophthalmology
2004-5Clinical Fellow in Vitreoretinal Surgery, Moorfields Eye Hospital
2003-4Specialist Registrar in Ophthalmology, Moorfields Eye Hospital
1989-92St. Mary's Hospital Medical School, London
1986-89King's College, Cambridge


CV of James Bainbridge [pdf]

Scientifc Interest

    • Retina
    • Gene therapy
    • Oxygen
    • Surgery


  • Association for Research in Vision and Ophthalmology (ARVO)
    • Royal College of Ophthalmologists
    • Medical Research Society
    • European Society of Ophthalmology

James Bainbridge
James Bainbridge

Research Group

Molecular Therapy Research


UCL Institute of Ophthalmology

11-43 Bath Street
London, EC1V 9 EL
United Kingdom

Phone: (44)2076086889


Division of Molecular Therapy

Key Publications

  1. Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, Viswanathan A, Holder GE, Stockman A, Tyler N, Petersen-Jones S, Bhattacharya SS, Thrasher AJ, Fitzke FW, Carter BJ, Rubin GS, Moore AT, Ali RR.
    Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis.
    N Engl J Med. 2008 358:2231–2239
  2. Mowat F, Luhmann U, Duran Y, Smith AJ, Harten S, Shukla D, Maxwell PH, Ali R and Bainbridge JWB.
    HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
    PLoS ONE. 2010; 5(6);e11103
  3. C Lange, P Stavrakas, UFO Luhmann, J da Silva, RR Ali, Z Gregor, J Bainbridge
    Intraocular oxygen distribution in advanced proliferative diabetic retinopathy.
    Am J Opththalmol. In press
  4. F Mowat, S Petersen-Jones, H Williamson, D Williams, P Luthert, R Ali and J Bainbridge.
    Detailed topographical characterisation of cone photoreceptors and the area centralis of the canine retina.
    Mol Vision 2008 2008;12:2518-27
  5. da Silva J, Kwan A, Bunce C and Bainbridge JWB.
    Predicting visual outcome following retinectomy for retinal detachment,
    Brit J Ophthal 2008 92 (7) 954-8
  6. JWB Bainbridge, A Mistry, FC Schlichtenbrede, A Smith, C Broderick, M De Alwis, A Georgiadis,  PM Taylor, M Squires, C Sethi, D Charteris, AJ Thrasher, D Sargan and RR Ali.
    Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina.
    Gene Therapy 2003; 10: 1336-44
  7. JWB Bainbridge, A Mistry, K Binley, M De Alwis, A Thrasher, S Naylor, R Ali.
    Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularisation
    Gene Therapy 2003; 10(12): 1049-54
  8. JWB Bainbridge, H Jia, D Selwood, RR Ali, and I Zachary.
    Peptides Encoded by exon 6 of VEGF inhibit VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo.
    Biochem Biophys Res Commun 2003; 302(4):793-9
  9. JWB Bainbridge, A Mistry, M De Alwis, E Paleog, A Baker, AJ Thrasher and RR Ali.
    Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.
    Gene Therapy 2002;9: 320-326
  10. JWB Bainbridge, C Stephens, K Fowler, C Demaison, A Halfyard, AJ Thrasher and RR Ali.
    In-vivo gene transfer to the mouse eye using an HIV-based lentiviral vector: efficient long-term transduction of corneal endothelium and retinal pigment epithelium.
    Gene Therapy 2001;8:1665-1668. 

                                    Research Groups