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Daniele Dell'Orco

Short CV

I studied Physics and Biophysics at the University of Parma (Italy) and Lund (Sweden). I obtained a PhD in Biotechnology and Molecular Medicine from the University of Modena and Reggio Emilia (Italy). During my pre- and post-doctoral activity I visited several laboratories in Sweden and in Germany, to improve my knowledge of computational and experimental biophysical chemistry and systems biology. I have been A. von Humboldt Research Fellow at the University of Oldenburg (Germany) for almost 2.5 years. Since December 2011 I am Assistant Professor at the University of Verona, at the Biological Chemistry section of the Medical Faculty.

On a regular basis I act as a referee for several peer-review journals in the fields of Biochemistry, Biophysical Chemistry, Systems Biology and biology-oriented nanoscience, among which:

  • Molecular Biosystems, Journal of Physical Chemistry B, PhysChemChemPhys, BBA-Proteins and Proteomics, PLoS Computational Biology, Integrative Biology, Cellular and Molecular Life Sciences, BioMaterials, ACS Nano, PLoS One, BioSystems

I teach Bioinformatics to undergraduate students in the bioinformatics and Biotechnology programs at the University of Verona.

Daniele Dell'Orco
Daniele Dell'Orco

Research Group

Biophysical Chemistry and Systems Biology of Vision

[more information]


University of Verona

Department of Life Sciences and Reproduction
Section of Biological Chemistry
Strada le Grazie 8
37134 Verona

Phone: +39-045-802-7637
Fax: +39 045-802-7170



Scientifc Interest

  • Experimental and theoretical characterization of protein-protein and protein-ion interactions involved in vertebrate vision
  • Biochemical mechanisms underlying complex photoreceptor cell behaviours in normal and disease-associated conditions
  • Calcium binding and calcium sensor proteins: biophysical properties and dynamics
  • Systems biology of signal transduction pathways and kinetic modeling
  • nanoparticle-protein interactions and perturbation of biochemical pathways exerted by nanodevices


  • Biochemical Society (UK)
  • Italian society of Biochemistry and Molecular Biology (SIB)
  • Bioinformatics Italian Society (BITS)

Key Publications

  1. Karl-Wilhelm Koch, Daniele Dell'Orco
    A Calcium-Relay Mechanism in Vertebrate Phototransduction.
    ACS Chemical Neuroscience 4: 6. 909–917 (2013)
  2. Patrick Zägel, Daniele Dell'Orco, Karl-Wilhelm Koch
    The Dimerization Domain in Outer Segment Guanylate Cyclase Is a Ca(2+)-Sensitive Control Switch Module.
    Biochemistry (in press) (2013)
  3. Brandon M Invergo, Ludovica Montanucci, Karl-Wilhelm Koch, Jaume Bertranpetit, Daniele Dell'Orco
    Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.
    Cell communication and signaling: CCS 11: 1. 05 (2013)
  4. Lorenzo Cangiano, Daniele Dell'Orco
    Detecting single photons: A supramolecular matter?
    FEBS Lett 587: 1. 1-4 (2013)
  5. Daniele Dell'Orco
    A physiological role for the supramolecular organization of rhodopsin and transducin in rod photoreceptors.
    FEBS letters 587: 13. 2060-2066 (2013)
  6. Simona Mariani, Daniele Dell'Orco, Angelo Felline, Francesco Raimondi, Francesca Fanelli
    Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.
    PLoS Comp Biol (in press) (2013)
  7. Daniele Dell'Orco, Martin Lundqvist, Tommy Cedervall, Sara Linse
    Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening.
    Nanomedicine 8: 8. 1271-1281 (2012)
  8. Daniele Dell'Orco, Karl-Wilhelm Koch
    A dynamic scaffolding mechanism for rhodopsin and transducin interaction in vertebrate vision.
    Biochem J 440: 2. 263-271 (2011)
  9. Daniele Dell'Orco, Petra Behnen, Sara Linse, Karl-Wilhelm Koch
    Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.
    Cell Mol Life Sci 67: 6. 973-984 (2010)
  10. Daniele Dell'Orco, Henning Schmidt, Simona Mariani, Francesca Fanelli
    Network-level analysis of light adaptation in rod cells under normal and altered conditions.
    Mol Biosyst 5: 10. 1232-1246 (2009)

    Research Groups