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Top 10 Innovations 2013

The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.

Despite formidable odds, this year was a good one for life science innovation. New and exciting products still made their way into the marketplace. And with more than 80 products submitted to this year’s Top 10 Innovations contest, our expert panel of judges had the tall task of whittling the crowded field down to the very best.

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nVista HD (Inscopix)

This mini fluorescence microscope allows researchers to observe neuronal activity in the brains of freely behaving mice.

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X-MAN Reporter Kits (Horizon Discovery)

These cell lines with built-in reporter constructs eliminates the need to treat cells with reporter-bearing plasmids.

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SmartFlare RNA Detection Probes (EMD Millipore)

These molecular probes allow fluorescent detection of internal RNA species without harm to the cell and eliminate the need for antibodies.

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SR GSD 3D (Leica Microsystems)

This update to an existing platform can image with resolutions of 20 nm in the XY plane and 70 nm on the Z axis combining that information to create 3-D images.

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Prosigna Breast Cancer Prognostic Gene Signature A! ssay (NanoString)

This assay determines the risk of breast cancer recurrence by examining the gene expression profile of the patient's tumor cells.

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ClearColi (Lucigen)

This is the first-ever line of E. coli that lacks the endotoxin lipopolysaccharide, instead expressing a nontoxic LPS precursor called lipid IVA, making it better able to produce clean proteins of interest.

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Humanized Bacterial Luciferase (490 BioTech)

This bioluminescent reporter system can be inserted into many cell types and does not need an additional substrate to light up.

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SynVivo (CFD Research Corporation)

This is a synthetic in vivo vascular environment on a microfluidic chip.

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NumaTac (SynTouch)

These pads contain sensors that allow robots to detect and respond to collisions.

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ADCC Reporter Bioassay (Promega)

This antibody-dependent, ! cell-mediated cytotoxicity reporter assay kit includes engineered huma n T cells developed from an immortalized cell line as effector cells.

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NOMe-Seq (Active Motif)

This technique (Nucleosome Occupancy and Methylome Sequencing) will allow scientists to track both DNA methylation and nucleosome positioning within the same DNA molecule.

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Quantitative Multiplex Reference Standard (Horizon Diagnostics)

This reference panel contains 30 PCR-validated mutations and provides scientists with well-characterized samples of cell line or DNA variants that they can use to validate the techniques they’re employing in the lab.