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David Hicks

David Hicks is principal investigator and full professor at the INSERM U.592, Strasbourg, France.

Short CV

1974-77 BsC Zoology (Hons.), Univ. Bristol, UK
1978-81 PhD Developmental Neurobiology, Woolwich Univ., London UK
1981-84 Postdoctoral Student, Dept. Biochem., Univ. B.C., Vancouver, B.C., Canada
1984-87 Postdoctoral Fellow, Lab. Neurobiol., Rockefeller Univ., New York, NY USA.
1987-88 Visiting Scientist, INSERM U.118, Paris, France
1988-92 Assistant Professor (Chargé de Recherche) INSERM, INSERM U.118, Paris, France.
1992-2004 Full Professor (Directeur de Recherche) INSERM, INSERM U.592, Strasbourg, France
2004-present Full Professor, CNRS UMR 7168/LC2, INCI, Strasbourg, France


CV of David Hicks [pdf]

Scientifc Interest

  • Cellular localisation and molecular mechanisms underlying rod photoreceptor circadian biology.
  • Role of circadian clock genes in retinal function and pathological consequences of clock perturbation.
  • Cone photoreceptor phagocytosis in cone-rich rodents and humans: circadian regulation, normal aging and age-related macular degeneration.
  • Experimental cone degeneration and neuroprotection: generation of transgenic cone-rich rodent models of human inherited retinal disease.
  • Experimental cone degeneration and neuroprotection: light- and drug-induced breakdown in cone-rich animal models of human vision.
  • Early changes in diabetic retinopathy: structural and functional studies using novel animal models.


  • Association for Research in Vision and Ophthalmology (ARVO)
  • Société Française de Chronobiologie
  • International Society for Eye research

Further Activities

  • Director, “Research Project” module, Joint Masters in Neuroscience, Univ. Louis Pasteur, Strasbourg, France.
  • Editorial Board Member, Investigative Ophthalmology & Visual Science.
  • Editorial Board Member, Journal of Ocular Biology, Diseases and Informatics.
  • Scientific Committee Member, Retina France.
  • Editorial Board Member, Graefe's Archives for Clinical and Experimental Ophthalmology.
David Hicks
David Hicks

Research Group

Circadian clocks and retinal pathophysiology


Institute of Cellular and Integrative Neurosciences

Department of Neurobiology of Rhythms, CNRS UMR 7168/LC
25 rue Blaise Pascal
67084 Strasbourg

Phone: 33 388 456 723

Email: photoreceptor67[at]

Key Publications

  1. Saïdi T, Mbarek S, Chaouacha-Chekir RB, Hicks D. (2011)
    Diurnal rodents as animal models of human central vision: characterisation of the retina of the sand rat Psammomys obsesus.
    Graefes Arch Clin Exp Ophthalmol. 249: 1029-37.
  2. Saïdi T, Mbarek S, Omri S, Behar-Cohen F, Chaouacha-Chekir RB, Hicks D. (2011)
    The Sand Rat Psammomys obesus develops Type 2 Diabeic retinopathy Similar to Humans.
    Invest Ophthalmol Vis Sci. 52: 8993-9004.
  3. Boudard DL, Acar N, Bretillon L, Hicks D. (2011)
    Retinas of the Diurnal Rodent Arvicanthis ansorgei Are Highly Resistant to Experimentally Induced Stress and Degeneration.
    Invest Ophthalmol Vis Sci. 52: 8686-700.
  4. Sandu C, Hicks D, Felder-Schmittbuhl MP. (2011)
    Rat photoreceptor circadian oscillator strongly relies on lighting conditions.
    Eur J Neurosci. 34: 507-16.
  5. Verra DM, Contín MA, Hicks D, Guido ME. (2011)
    Early onset and differential temporospatial expression of melanopsin isoforms in the developing chicken retina.
    Invest Ophthalmol Vis Sci. 52: 5111-20.
  6. Hicks D. (2011)
    Second sight?
    Graefes Arch Clin Exp Ophthalmol. 249: 313-4.
  7. Krigel A, Felder-Schmittbuhl MP, Hicks D. (2010)
    Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouse.
    Mol Vis. 16: 2873-81.
  8. Sparrow JR, Hicks D, Hamel C. (2010)
    Retinal pigmented epithelium in health and disease.
    Curr Mol Med. 10: 802-23 .
  9. Mehdi MK, Hicks D. (2010)
    Structural and physiological responses to prolonged constant lighting in the cone-rich retina of Arvicanthis ansorgei.
    Exp Eye Res. 91: 793-9.
  10. Boudard DL, Tanimoto N, Huber G, Beck SC, Seeliger MW, Hicks D. (2010)
    Cone loss is delayed relative to rod loss during induced retinal degeneration in the diurnal cone-rich rodent Arvicanthis ansorgei.
    Neuroscience. 169: 1815-30.
  11. Boudard DL, Mendoza J, Hicks D. (2009)
    Loss of photic entrainment at low illuminances in rats with acute photoreceptor degeneration.
    Eur J Neurosci. 30:1527-36.
  12. Bobu C, Hicks D. (2009)
    Regulation of retinal photoreceptor phagocytosis in a diurnal mammal by circadian clocks and ambient lighting.
    Invest Ophthalmol Vis Sci. 50:3495-502.
  13. Tezcaner A, Hicks D. (2008)
    In vitro characterization of micropatterned PLGA-PHBV8 blend films as temporary scaffolds for photoreceptor cells.
    J Biomed Mater Res A. 86:170-81.
  14. Siffroi-Fernandez S, Felder-Schmittbuhl MP, Khanna H, Swaroop A, Hicks D. (2008)
    FGF19 exhibits neuroprotective effects on adult photoreceptors in vitro.
    Invest Ophthalmol Vis Sci. 49: 1696-704.
  15. Bobu C, Lahmam M, Vuillez P, Ouarour A, Hicks D. (2008)
    Photoreceptor organisation and phenotypic characterization in retinas of two diurnal rodent species: potential use as experimental animal models for human vision research.
    Vision Res. 48: 424-32.

Research Groups