Short CV
- Alberto Auricchio, MD is Associate Professor of Medical Genetics at the “Federico II” University in Naples and Full Investigator at the Telethon Institute of Genetics and Medicine in Naples.
- Dr. Auricchio’s research is focused on gene therapy of retinal and metabolic diseases using adeno-associated viral vectors.
- Dr. Auricchio is co-author of more than 60 peer-reviewed publications on international scientific journals.
- Dr. Auricchio is inventor on several international patents on the use of viral vectors for gene therapy.
- Dr. Auricchio is a member of the Editorial boards of Human Gene Therapy and Molecular Therapy.
- Dr. Auricchio received the 2006 Outstanding New Investigator Award of the American Society of Gene Therapy
- Dr. Auricchio has been nominated in 2007 "Cavaliere of the Italian Republic" by the President of the Italian Republic.
- Development and application of viral vectors for retinal gene transfer for retinal degeneration and neovascularization.
- Translational research for gene therapy of inherited retinaldegenerations (Leber’s congenital amaurosis, Stargardt’s disease, retinitis pigmentosa)
Further Activities
- Gene therapy mediated by adenoassociated viral vectors for treatment of Lysosomal Storage Disorders
- American Society of Gene Therapy (ASGT)
- Association for Research in Vision and Ophthalmology (ARVO)
- European Society of Gene Therapy (ESGT)
- New York Academy of Sciences: 2004-2005
Alberto Auricchio |
Research Group
Telethon Institute Of Genetics And Medicine (TIGEM)
[more information]
Contact
Telethon Institute Of Genetics And Medicine
Via Pietro Castellino, 111
80131 Naples
Italy
Phone: 0039-081-6132229
Fax: 0039-081-5790919
Email:
auricchio[at]tigem.it
Website:
www.tigem.it
Key Publications
- F. Simonelli, A.M. Maguire, F. Testa, E.A. Pierce, F. Mingozzi, J.L. Bennicelli, S. Rossi, K. Marshall, S. Banfi, E.M. Surace, J. Sun, T.M. Redmond, X. Zhu, K.S. Scindler, G.S. Ying, C. Ziviello, C. Acerra, J.F. Wright, J.W. McDonnell, K.A. High, J. Bennett, A.Auricchio (2009)
Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration.
Mol. Ther. 18(3):643-50. PMID: 19953080. - A.M. Maguire, K.A. High, A. Auricchio, J.F. Wright, E.A. Pierce, F. Testa, F. Mingozzi, J.L. Bennicelli, G.S. Ying, S. Rossi, A. Fulton, K.A. Marshall, S. Banfi, D.C. Chung, J.I. Morgan, B. Hauck, O. Zelenaia, X. Zhu, L. Raffini, F. Coppieters, E. De Baere, K.S. Shindler, N.J. Volpe, E.M. Surace, C. Acerra, A. Lyubarsky, T.M. Redmend, E. Stone, J. Sun, J.W. McDonnell, B.P. Leroy, F. Simonelli, J. Bennett (2009)
Age-dependent effects of RPE65 gene therapy for Leber’s congenital amaurosis: a phase 1 dose escalation trial.
Lancet. 7;374(9701):1597-605. PMID: 19854499. - A. Bello, K. Tran, M. Doria, M. Allocca, M. Hildinger, D. Beniac, C. Kranendonk, A. Auricchio, G. P. Kobinger (2009)
Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues.
Gene Therapy advance online publication 23 July 2009. PMID: 19626054. - P. Colella, G. Cotugno, A. Auricchio (2009)
Ocular gene therapy:current progress and future prospects. Trends in Molecular Medicine. 15(1):23-31. PMID: 19097940 IF 9.621 - A. M. Maguire, F. Simonelli, E. A. Pierce, E. N. Jr Pugh, F. Mingozzi, J. Bennicelli, S. Banfi, K. A. Marshall , F. Testa , E. M. Surace, S. Rossi, A. Lyubarsky, V.R. Arruda, B. Konkle, E. Stone, J. Sun, J. Jacobs, L. Dell'Osso, R. Hertle, J. X. Ma, T. M. Redmond, X. Zhu, B. Hauck, O. Zelenaia, K. S. Shindler, M. G. Maguire, J. F. Wright, N. J. Volpe, J. W. McDonnell, A. Auricchio *, K.A. High *, J. Bennett* (2008)
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis.
N Engl J Med. 358(21):2240-8. *co-corresponding authors. PMID: 18441370 - M. Allocca, M. Doria, M. Petrillo, M. P. Colella, G. Hoyos, D. Gibbs , S. R. Kim, A. Maguire, T. S. Rex, U. Di Vicino, L. Cutillo, J. R. Sparrow, D. S.Wiliams, J. Bennett and A. Auricchio (2008)
Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective in vivo gene delivery.
J. Clin. Invest. 118(5):1955-64. PMID: 18414684 - M. Allocca, U. Di Vicino, M. Petrillo, F. Carlomagno, L. Domenici, A. Auricchio (2007)
Constitutive and AP20187-induced ret activation in photoreceptors does not protect from light-induced damage.
IOVS. 48(11):5199-206. PMID:17962474 - M. Allocca, C. Mussolino, M. Garcia-Hoyos, D. Sanges, C. Iodice, M. Petrillo, L. H. Vandenberghe, J. M. Wilson, V. Marigo, E. M. Surace, A. Auricchio (2007)
Novel adeno-associated virus serotypes efficiently transduce murinephotoreceptors.
J Virol. 81(20):11372-80. PMID: 17699581. - Tessitore, F. Parisi, M. A. Denti, M. Allocca, U. Di Vicino, L. Domenici, I. Bozzoni, A. Auricchio (2006)
Preferential silencing of a common dominant rhodopsin mutation does not inhibit retinal degeneration in a transgenic model.
Mol. Ther. 14(5):692-9. PMID:16979943 - E. M. Surace, K. S. Balaggan, A. Tessitore, C. Mussolino, G. Cotugno, C. Bonetti, A. Vitale, R. R. Ali, A. Auricchio (2006)
Inhibition of ocular neovascularization by Hedgehog blockade.
Mol. Ther. 13(3):573-9. PMID: 16343995.
Research Groups
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