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Eberhart Zrenner

Prof. Zrenner is Chair-Professor for Ophthalmology at the Institute for Ophthalmic Research of the Centre for Ophthalmology at the University of Tuebingen. His research interests include: retinal physiology and pathophysiology, retinal degeneration, ophthalmogenetics, neuro-ophthalmology, retina implants, electrophysiology and other methods of non-invasive function testing. Since 1989 he is in charge of a special clinic for hereditary retinal diseases. He also is Coordinating Principal Investigator of a multicenter study that develops subretinal active microphotodiode arrays (MPDAs) to replace degenerated photoreceptors. He has contributed to 10 patent families. He is coordinator in 3 major EU-Projects.

He studied electronic engineering as well as medicine at the Technical University Munich, where he obtained his MD degree in 1972. Subsequently he worked within the Max Planck-Society for 16 years and received a Fogarty fellowship at the National Eye Institute, NIH, Bethesda, MD (1977 and 1978), studying temporal, spatial and chromatic characteristics of retinal ganglion cells via extracellular recordings in monkey retina. After acquiring a PD degree he received an Associate Professorship at the University Eye Hospital in Munich. He became full professor and Medical Director of the University Eye Hospital in Tuebingen in 1989, now Centre for Ophthalmology. Presently he also serves as Head of Pathophysiology of Vision at the Institute for Ophthalmic Research and Chairman of the Tuebingen Centre for Neurosensory Systems. He has received numerous grants and awards and has published approximately 400 peer reviewed papers (see home page)


CV of Eberhart Zrenner [pdf]

Scientifc Interest

  • Physiology and pathophysiology of the visual system
  • Neuroophthalmology; Functional and neuropharmacological studies in vivo
  • Neuroprosthetics; psychophysics; clinical electrophysiology
  • Color vision; hereditary retinal degeneration
  • Non-invasive techniques of functional diagnostics in ophthalmology; ocular toxicology


  • President of the International Society for Clinical Electrophysiology of Vision
  • Member of the “Wissenschaftsrat”
  • ARVO
  • German Academy of Sciences
  • AAO
Eberhart Zrenner
Eberhart Zrenner

Research Group


[more information]


Universitätsklinikum Tübingen

Centre for Ophthalmology, Institute for Ophthalmic Research

Schleichstr. 12 - 16
72076 Tuebingen

Phone: +49-7071-29-84786 or -87311
Fax: +49-7071-29-5038



Key Publications

  1. Zrenner E et al.
    Subretinal electronic chips allow blind patients to read letters and combine them to words.
    Proc. R. Soc. B. 278, 1489-1497(2011). doi: 10.1098/rspb.2010.1747
  2. Wilke R, Gabel VP, Sachs H, Bartz Schmidt KU, Gekeler F, Besch D, Szurman P, Stett A, Wilhelm B, Peters T, Harscher A, Greppmaier U, Kibbel S, Benav H, Bruckmann A, Stingl K, Kusnyerik A, Zrenner E.,
    Spatial Resolution and Perception of Patterns Mediated by a Subretinal 16-Electrode Array in Patients Blinded by Hereditary Retinal Dystrophies.
    INVEST OPHTH VIS SCI 52, pp. 5995-6003 (2011
  3. Schatz A, Röck T, Naycheva L, Willmann G, Wilhelm B, Peters T, Bartz-Schmidt KU, Zrenner E, Messias A, Gekeler F .
    Transcorneal Electrical Stimulation for Patients with Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Exploratory Study.
    INVEST OPHTH VIS SCI 52, 4485-4496 (2011)
  4. Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F.
    PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function.
    PLOS ONE 5, e15495-e15503 (2010)
  5. Messias A, Zrenner E, Tzekov R, McGee D, Peters T, Wilhelm B, Baryluk A, Kubota R, Gekeler F.
    Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats.
    DOC OPHTHALMOL 120, 165-174 (2010)
  6. Kitiratschky VBD, Wilke R, Renner AB, Kellner U, Vadalà M, Birch DG, Wissinger B, Zrenner E, Kohl S.
    Mutation Analysis Identifies GUCY2D as the Major Gene Responsible for Autosomal Dominant Progressive Cone Degeneration.
    Invest Ophth Vis Sci 49, 5015-5023 (2008)
  7. Zrenner E:
    The role of electrophysiology and psychophysics in ocular toxicology. Clinical and Ocular Toxicology.
    Elsevier Inc. (2008)
  8. Zrenner E:
    Will Retinal Implants Restore Vision?
    Science 295, 1022-1025 (2002)
  9. Seeliger M, Grimm C, Stählberg F, Friedburg F, Jaissle G, Zrenner E, Guo H, Remé CE, Humphries P, Hofmann F, Biel M, Fariss RN, Redmond TM, Wenzel A:
    New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.
    Nature Genetics 29, 70-74 (2001)
  10. Kohl S, Marx T, Giddings I, Jägle H, Jacobson SG, Apfelstedt-Sylla E, Zrenner E, Sharpe LT, Wissinger B:
    Total colourblindness is caused by mutations in the gene encoding the (-subunit of the cone photoreceptor cGMP-gated cation channel.
    Nature Genetics 19, 257-259 (1998)

Research Groups