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Tony Moore

Tony Moore is the Duke Elder Professor of Ophthalmology at the Institute of Ophthalmology, UCL London. He has honorary consultant appointments at Moorfields Eye Hospital and the Hospital for Children ,Great Ormond Street, London where he has his clinical practice. He is Director of the Paediatric Ophthalmology Service at Moorfields Eye Hospital.

His main research interests are in inherited eye disease particularly those affecting the retina

Scientifc Interest

My main scientific interests are in investigating the molecular genetic basis of inherited eye disease and in investigating the associated disease phenotype. The long term aim of this research is to develop novel therapies for this group of disorders which are currently not amenable to treatment.


  • Association for Research in Vision and Ophthalmology (ARVO)
  • EVER
  • Academy of Medical Sciences UK
  • Royal College of Ophthalmologists UK
  • Academia Ophthalmologica Internationalis
Tony Moore
Tony Moore

Research Group

Inherited Eye Disease

[more information]


Institute of Ophthalmology

11-43 Bath Street
EC1V 9EL London
United Kingdom

Phone: +442075662260



Key Publications

  1. Berry V, Francis P, Kaushal S, Moore AT, Bhattacharya S.
    Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q.
    Nat Genet. 2000;25:15-17
  2. Alexander C, Votruba M, Pesch UE, Thiselton DL, Mayer S, Moore A, Rodriguez M, Kellner U, Leo-Kottler B, Auburger G, Bhattacharya S, Wissinger B.
    OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.
    Nat Genet 2000;26:211-215
  3. Sisodiya SM, Free SL, Williamson KA, Mitchell TN, Willis C, Stevens JM, Kendall, BE, Shorvon SD, Hanson IM, Moore AT, van Heyningen V.
    PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans.
    Nat Genet. 2001;28:214-6
  4. Michaelides M,Holder GE, Webster A, Hunt DM, Bird AC, Fitzke F, Mollon JD, Moore AT.
    A detailed study of the phenotype of an unusual progressive cone dystrophy with supernormal rod responses.
    Br J Ophthalmol 2004;88:497-500
  5. Johnson S, Michaelides M, Aligianis IA, Ainsworth JR, Mollon JD, Maher ER, Moore AT, Hunt DM.
    Achromatopsia caused by novel mutations in both CNGA3 and CNGB3.
    J Med Genet 2004;41:e20.
  6. Michaelides M, Aligianis IA, Ainsworth JR, Good P, Mollon JD, Maher ER, Moore AT, Hunt DM.
    Progressive cone dystrophy associated with mutation in CNGB3.
    Invest Ophthalmol Vis Sci 2004;45:1975-82
  7. Wu H, Cowing JA, Michaelides M, Wilkie SE, Jeffery G, Jenkins SA, Mester V, Bird AC, Robson AG, Holder GE, Moore AT, Hunt DM, Webster AR.
    Mutations in the Gene KCNV2 Encoding a Voltage-Gated Potassium Channel Subunit Cause "Cone Dystrophy with Supernormal Rod Electroretinogram" in Humans.
    Am J Hum Genet. 2006;79:574-9.
  8. Henderson RH, Waseem N, Searle R, van der Spuy J, Russell-Eggitt I, Bhattacharya SS, Thompson DA, Holder GE, Cheetham ME, Webster AR, Moore AT.
    An assessment of the apex microarray technology in genotyping patients with Leber congenital amaurosis and early-onset severe retinal dystrophy.
    Invest Ophthalmol Vis Sci. 2007;48:5684-9
  9. Bainbridge J, Smith AJ, Barker SS, et al.
    Effect of gene therapy in adults with Leber Congenital Amaurosis.
    N Engl J Med. 2008 Apr 27.[Epub ahead of print]
  10. Yates,J.R., Sepp,T., Matharu,B.K., Khan,J.C., Thurlby,D.A., Shahid,H., Clayton,D.G., Hayward,C., Morgan,J., Wright,A.F., Armbrecht,A.M., Dhillon,B., Deary,I.J., Redmond,E., Bird,A.C., Moore,A.T. (2007).
    Complement C3 variant and the risk of age-related macular degeneration.
    N.Engl.J.Med. 357(6), 553-561

Research Groups