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Experimental Ophthalmology

Our group focuses on the development of immune therapies against retinal degeneration. We are convinced that the imbalance of the local, retinal complement system is an important player in pathogenesis of retinal dystrophies. We concentrate on the basic mechanism of the complement system in retinal physiology and aim to develop drugs, which maintain the retinal immune homeostasis during aging.


  • Molecular biology (recombinant proteins, qPCRs),
  • immunological techniques (Western, ELISA, Immuostainings),
  • we generate our own antibodies,
  • ERG measurements in mice,
  • RPE cell culture

Group Leader

Diana Pauly
[more information]


University Hospital Regensburg

Franz-Josef Strauss Allee 11
93053 Regensburg

Phone: +49 (0) 941 944 9228



Scientific Cooperations

  • Cooperation 1:
    Prof. Antje Grosche, LMU, Munich, Germany
  • Cooperation 2:
    Prof. Barbara Braunger, University Würzburg, Germany
  • Cooperation 3:
    Prof. Volker Enzmann, University Hospital Bern, Switzerland

Current Research Projects

  • Project 1
    Function of Properdin at the RPE
  • Project 2
    FHR3/FHR1- complement regulators in the eye
  • Project 3
    Oxidative stress results in RPE-cell dependent activation of the complement system
  • Project 4
    Development of a complement multiplex assay for minimal sample volume
  • Project 5
    Cell-type specific complement expression in the retina

Research Groups