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University of Bonn,
Department of Ophthalmology

Imaging, pathogenesis and treatment of retinal/macular diseases

Research Group of Dr. Frank G. Holz in Bonn, Germany

  • Clinical researchers – 15 physicians, 12 doctoral-/PhD-students, 4 technical assistants, 4 nurses
  • Laboratory researchers – 3 PhDs, 4 physicians, 3 doctoral students, 4 technical assistants
  • Imaging facility – 5 physicians, 3 photographer, 3 technicians, 4 technical assistants
  • Study coordination center – 2 physicians, 2 study-nurses
  • GRADE-Reading Center – 3 physicians


  • Confocal scanning laser ophthalmoscopy, spectral-domain optical coherence tomography, macular pigment density measurement, microperimetry, automated image analysis
  • Cell culture, pulse-chase experiments, FACS
  • Laser mouse models

Group Leader

Dr. Frank G. Holz

more information


University of Bonn, Germany

Department of Ophthalmology
Imaging, pathogenesis and treatment of retinal/macular diseases

Ernst-Abbe-Strasse 2
D-53127 Bonn

Phone: +49 228 287 15647
Fax: +49 228 287 15603




Cooperation 1:
Prof. Dr. rer. nat. Jürgen Kopitz, Department of Pathobiochemistry, University of Heidelberg, Germany

Cooperation 2:
Prof. Dr. Bernhard Weber, Department of Human Genetics, University of Regensburg, Germany

Cooperation 3:
Prof. Dr. Josef Bille, Department of Applied Physics, University of Heidelberg, Germany

Cooperation 4:
Professor Dr. rer.nat Ulrich Mansmann, Department of  Biometry and Bioinformatics, Ludwig Maximilians University Munich, Germany

Cooperation 5:
Dr. rer. nat. Gerhard Zinser; Dr. rer. nat. Tilmann Otto, Heidelberg Engineering, Dossenheim, Germany

Cooperation 6:
Prof. Dr. rer. nat. Martin Oppermann, Department of Cellular and Molecular Immunology, University of Göttingen, Göttingen, Germany

Cooperation 7:
Janet Sunness, MD, Richard E. Hoover Rehabilitation Services for Low Vision and Blindness, Greater Baltimore Medical Center, Baltimore, USA

Cooperation 8:
Professor Alan C. Bird, Moorfields Eye Hospital, London, UK

Cooperation 9:
Professor Frederick W. Fitzke, PhD, Institute of Ophthalmology, London, UK

Cooperation 10:
Professor Giovanni Staurenghi, Department of Ophthalmology, University of Brescia, Italy

Cooperation 11:
Prof. Dr. Winfried Denk, Dr. Günter Giese,  Max-Planck-Institute for Medical Research, Heidelberg, Germany

Cooperation 12:
Professor Glenn Jaffe, MD, PhD, Department of Ophthalmology, DUKE University, Durham, USA

Cooperation 13:
Richard F. Spaide, MD,  Vitreous, Retina, Macula Consultants, New York, USA

Cooperation 14:
Jason Slaktor, MD, DARC Reading Center, New York, USA

Cooperation 15:
Dr. Michael Schirner, Mivenion, Berlin, Germany

Cooperation 16:
Dr. Chrisoph Russman, Dr. Manfred Dick, Carl Zeiss Meditec, Jena, Germany

Cooperation 17:
Prof. Dr. Percy Knolle, Prof. Dr. C. Kurts, Institute of molecular medicine and experimental immunology, Germany

Cooperation 18:
Certified member and participant of the EVI.CT.SE group

Current Research Projects

Project 1:
High-resolution, multimodal retinal imaging: confocal scanning-laser-ophthalmoscopy, spectral domain OCT, fundus autofluorescence, blue-reflectance imaging (clinical research)

Project 2:
Lysosomal –mediated damage by lipid peroxidation (experimental research)

Project 3:
Biomarkers in AMD (clinical research)

Project 4:
Molecular and cellular imaging in age-related macular degeneration (AMD) (experimental research)

Project 5:
Role of dendritic cells in AMD (experimental research)

Project 6:
Complement- and cytokine-profiling in AMD (experimental research)

Project 7:
Genetics in AMD (clinical research)

Project 8:
Tissue-engineering: Bruch membrane prosthesis for sheet transplantation in AMD (experimental research)

Project 9:
Fundus-controlled microperimetry, correlation of morphology and function in retinal diseases (clinical research)

Project 10:

Bruch membrane-RPE-photoreceptor-alterations in Pseudoxanthoma elasticum (PXE) – a model for AMD (clinical research)

Project 11:
Macula pigment measurement in macular dystrophies (clinical research)

Project 12:
Natural history of macular telangiectasia type 2 (clinical study)

Project 13:
Reading centre for digital fundus autofluorescence (GRADE-Center) (clinical research)

Project 14: Quality of life in AMD (clinical research)

Project 15:
New therapeutic approaches in AMD (clinical study)

Project 16:
New drugs in diabetic retinopathy (clinical study)

Project 17:
New therapeutic approaches in retinal vein occlusion (clinical study)

Project 18:
Investigator initiated trial (IIT): anti-VEGF therapy in PXE (clinical study)

Project 19:
Investigator initiated trial (IIT): anti-VEGF therapy in macular telangiectasia (clinical study)

Project 20:
Botolinum toxin in blepharospasm (clinical study)

Project 21:
New drugs in dry eye syndrome (clinical study)

Project 22:
Two-Photon–Excited Fluorescence Imaging of Human RPE Cells with a Femtosecond Ti:Sapphire Laser

Research Groups