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Keith Meek

Short CV

Professor Keith Meek joined Cardiff University in 1999 from the Open University, where he was Director of the Oxford Research Unit and Chair of the Biophysics Group.

Keith Meek is currently Chair of the Structural Biophysics Group at Cardiff University, one of the largest such groups in the UK.

Professor Keith Meek has an honorary position in the Nuffield Department of Ophthalmology, Oxford University and ongoing research collaborations with groups at Moorfields, Leeds, Edinburgh, Dundee, Pittsburgh, Baltimore and Stanford.

Scientifc Interest

My interests include the structure and transparency of the cornea, and the structural causes of transparency loss in a number of pathological and post-surgical conditions. As a connective tissue scientist, my focus is on the collagen and proteoglycans in the cornea and sclera.


  • Association for Research in Vision and Ophthalmology (ARVO)
  • ISER
  • Royal Microscopical Society

Research Group

Structural Biophysics


Cardiff University

School of Optometry and Vision Sciences
Maindy Road
CF24 4LU
United Kingdom

Phone: +44 2920 876317
Fax: +44 2920 874859



Key Publications

  1. Doutch J, Quantock AJ, Smith VA and Meek KM
    Light transmission in the human cornea as a function of position across the ocular surface: theoretical and experimental aspects.
    Biophys. J. 95:5092-5099. (2008)
  2. Mi S, Yang X, Zhao Q, Qu L, Chen S, Meek KM and Dou Z.
    Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a goat model.
    Mol. Reprod. and Dev. In Press (2008)
  3. Samaras K, O’Brart DP, Doutch J, Hayes S, Marshall J and Meek KM
    Analysis of the light transmission properties of porcine corneas after riboflavin/ultraviolet A (370nm) corneal collagen crosslinkage to assess corneal stromal riboflavin absorption:a comparison of 20% alchohol application and partial and complete epithelial removal.
    J. Cataract and Ref. Surg. In Press (2008)
  4. Meek KM
    The cornea and sclera.
    In Collagen, Structure and Mechanics (P.Fratzl, ed.) pp359-396. Springer, NY. (2008)
  5. Akhtar S, Kerr BC, Hayes AJ, Hughes CE, Meek KM and Caterson B.
    Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus, using a keratanase generated neoepitope monoclonal antibody.
    IOVS. 49:2424-31(2008)
  6. Hayes S, O’Brart DP, Lamdin LS, Doutch J, Samaras K, Marshall J and Meek KM.
    An investigation into the importance of complete epithelial debridement prior to Riboflavin/Ultraviolet A (UVA) corneal collagen cross-linkage therapy.
    J. Cataract and Ref. Surg. 34:657-61 (2008)
  7. Akhtar S, Bron AJ, Salvi SM, Hawksworth NR, Tuft SJ and Meek KM
    Ultrastructural analysis of collagen fibrils and proteoglycans in keratoconus.
    Acta Ophthalmologica Scandinavica. 86:764-72 (2008)
  8. Boote C, Hayes, S, Jones, S, Quantock, AJ, Hocking, PM,; Inglehearn, CF, Ali, M,and Meek KM
    Collagen organisation in the chicken cornea and structural alterations in the retinopathy,globe enlarged (rge) phenotype - an x-ray diffraction study.
    J. Struct. Biol. 161:1-8 (2008)
  9. Hayes S, Boote C., Tuft SJ, Quantock AJ and Meek KM
    A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and x-ray scattering techniques.
    Exp. Eye Res. 84 423-434 (2007)
  10. Hayes S, Boote C, Lewis J, Sheppard J., Abahussin M., Quantock AJ, Purslow C, Votruba M and Meek KM.
    Comparative study of fibrillar collagen arrangement in the corneas of primates and other mammals.
    The Anatomical Record. 290. 1542-1550 (2007)

Research Groups