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Alan W. Stitt

Short CV

  • 1998 - Non-Clinical Lecturer in Ophthalmology Queen’s University of Belfast
  • 1999 - Reader in Ophthalmology Queen’s University of Belfast
  • 2001 - Harold McCauley Chair in Experimental Ophthalmology Queen’s University of Belfast
  • Director, Centre for Vision & Vascular Science, Queen’s University

Scientifc Interest

My current research interests fall into three main themes:

  • The pathogenic role of advanced glycation endproducts (AGEs) and RAGE in diabetic retinopathy
  • Retinal angiogenesis including harnessing the regenerative potential of endothelial progenitor cells for ischaemic retinopathies
  • The pathobiology of age-related retinal dysfunction and RPE biology


  • British Microcirculation Society
  • Association for Research in Vision and Ophthalmology (ARVO)
  • International Maillard Reaction Society (IMARS)

Further Activities

  • Juvenile Diabetes Research Foundation (JDRF) New York.
  • Scientific review committee  (Complications section) (from August 2004 - present)
  • Fight for Sight (UK) Grant Advisory Panel (GAP) member (2006-present)
  • Diabetes Research and Wellness Foundation (DWRF) – Research Grant Board (2008-present)
  • Medical Research Council (MRC) – “Models of Disease” grant panel June 2008
  • National Institute for Health (NIH) Center for Scientific Review (2009).
Alan Stitt
Alan Stitt

Research Group

Research Group of Alan Stitt

[more information]


Queen’s University Belfast

Centre for Vision & Vascular Science,
School of Medicine, Dentistry & Biomedical Science
Royal Victoria Hospital

Belfast BT12 6BA
Northern Ireland UK

Phone: 011 44 (0) 28-90632546
Fax: 011 44 (0) 28-90632699



Key Publications

  1. Beattie RJ, Pawlak AM, Boulton ME, Zhang J, Monnier VM, McGarvey JJ, Stitt AW (2010).
    Multiplex analysis of age-related protein and lipid modifications in human Bruch’s membrane. 
    FASEB Journal  24(12) 4816-4824.
  2. McVicar CM, Colhoun LM, Kitson CL, Hamilton R,  Medina RJ, Gardiner T & Stitt AW (2010)
    Differential modulation of angiogenesis by erythropoiesis-stimulating agents in ischaemic retinopathy. 
    PLOS One 5(7) e11870 1-16.
  3. Medina RJ, O’Neill CL, Humphreys MW, Gardiner TA, Stitt AW (2010)
    Outgrowth endothelial cells characterisation and their potential for reversing ischaemic retinopathy”
    Investigative Ophthalmology & Visual Science 51(11):5906-13.
  4. Zong H, Madden A, Ward MS, Moody M, Elliott C, Stitt AW (2010).
    Homodimerisation is essential for the receptor for advanced glycation endproducts (RAGE)-mediated signal transduction
    J Biol Chem 23;285(30):23137-46
  5. Zong H, Madden A, Ward M, Stitt AW (2010).
    The role of RAGE in Muller cell dysfunction during diabetic retinopathy.
    Diabetologia 53(12):2656-66.
  6. Medina RJ, O'Neill CL, Humphreys MW, Simpson DA, Gardiner TA, Stitt AW. (2010)
    Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.
    BMC Medical Genomics 13;3(1):18.
  7. Bhatwadekar AD, Glenn JV, Curtis TM, Grant MB, Stitt AW & Gardiner TA (2009)
    Retinal Endothelial Cell Apoptosis Stimulates Recruitment of Endothelial Progenitor Cells.
    Investigative Ophthalmology & Visual Science 50(10):4967-73.
  8. Medina RJ, O’Neil CL, Devine AB, Gardiner TA & Stitt AW (2008)
    The Pleiotropic Effects Of Simvastatin On Retinal Microvascular Endothelium Has Important Implications For Ischaemic Retinopathies.
    PLoS One 3 (7): e2584 1-12.
  9. Glenn JV, Mahaffy H, Wu K, Smith G, Nagai R, Simpson DAC, Boulton ME & Stitt AW (2008)
    AGE-modified substrate induces global gene expression changes in ARPE-19 monolayers: relevance to lysosomal dysfunction and lipofuscin accumulation. 
    Investigative Ophthalmology & Visual Science 50(1):441-51.
  10. Nagaraj RH, Linetsky M & Stitt AW (2010)
    The Pathogenic Role of the Maillard Reaction in the Ageing Eye. 
    Amino Acids Oct 21[Epub ahead of print]
  11. Stitt AW (2010)
    The role of AGEs in diabetic retinopathy.
    Investigative Ophthalmology & Visual Science;51(10):4867-74.
  12. Curtis TM, Gardiner TA & Stitt AW (2009)
    Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?
    Eye 23(7):1496-508

Research Groups