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Imre Lengyel


CV of Imre Lengyel [pdf]

Scientifc Interest

  • Normal and pathological aging of the retina
  • Age related macular degeneration
  • Genomics and proteomics of zinc nutrition
  • Biochemical basis of sub-RPE deposit formation
  • Genotype and phenotype of peripheral pathologies.


  • Biochemical Society
  • Association for Research in Vision and Ophthalmology (ARVO)
  • Royal Society of Medicine
  • International Society for Neurochemistry
Imre Lengyel
Imre Lengyel

Research Group

Ocular Biology and Therapeutics


UCL Institute of Ophthalmology

11-43 Bath Street
London EC1V 9EL
United Kingdom




Key Publications

  1. Sallo, F.B., Bereczki E., Csont, T., Luthert, P.J., Munro, P., Ferdinandy, P., Sántha, M. and Lengyel, I.:
    Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes.
    (2009) Exp Eye Res. 89(2):178-186
  2. Nan, R., Gor, J., Lengyel, I. and Perkins, S.J.,:
    Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator Factor H and its possible implications for function and disease.
    (2008) J Mol Biol. 384(5):1341-1352
  3. I. Lengyel and Peto T:
    Cure or cause: the opposing roles for zinc in age-related macular degeneration
    (2008) Expert Rev Ophthal. 3 1-4
  4. I. Lengyel, Flinn, J.M, Peto T, Linkous, D.H, Cano, K, Bird A.C, Lanzirotti A, Frederickson C.J. and van Kuijk F.J.G.M:
    High concentration of zinc in sub-retinal pigment epithelial deposits
    (2007) Exp Eye Res. 84 772-780 (see news coverage:
  5. I. Lengyel, R. Thomas, C.J. Frederickson and T. Pető (2006)
    Zinc and age-related macular degeneration In Trace Elements in the Food Chain
    Eds: M, Szilagyi, K. Szentmihalyi.
    Publisher: Hungarian Academy of Sciences, ISBN 963 7067 132, pages: 411-415
  6. I. Lengyel, A. Tufail, H. Al-Hossain, P. Luthert, A. Bird and G. Jeffery:
    The association of drusen deposition with capillary walls in the aging human eye
    (2004) Invest Ophthalmol Vis Sci. 45 2886–2892
  7. Zs. Molnar, P. Kovács, I. Lazckó, K. Soós, L. Fülöp, B. Penke and I. Lengyel:
    Enhanced G-protein activation by a mixture of Aß(25-35), Aß(1-40/42) and zinc
    (2004) J Neurochem 89 1215–1223
  8. J. Xue, X. Wang, M. Kinoshita, P.J. Milburn, I. Lengyel, J.A.P. Rostas, P.J. Robinson:
    Phosphorylation of a new brain-specific septin, G-septin, by cyclic GMP-dependent protein kinase.
    (2000) J Biol Chem, 275, 10047-10056
  9. I. Lengyel, S. Fieuw-Makaroff, A.L. Hall, A.T.R. Sim, J.A.P. Rostas, P.R. Dunkley:
    Modulation of the activity of Calcium/Calmodulin-stimulated protein kinase II by zinc.
    (2000) J Neurochem 75, 594605.
  10. I. Lengyel, L.E. Olesen, K.A. Nichol, K.L. Brain, P.J. Robinson, X. Wang, M.R. Bennett and J.A.P. Rostas (1999)
    Protein phosphorylation in chick ciliary ganglion under conditions that induce long lasting change in synaptic transmission: phosphoprotein targets for nitric oxide action.
    Neuroscience, 90, 607-619

Research Groups