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Astrid Limb

Short CV

Research area: Investigation of cellular and molecular mechanisms that promote differentiation of human Müller  stem cells into different types of retinal neurons. 

We also examine methods that may be potentially used for functional transplantation of these cells into degenerated retina.


CV of Astrid Limb [pdf]

Scientifc Interest

  • Müller glia function
  • Müller  stem cells
  • Retinal transplantation
  • Neural differentiation of retinal progenitors

Further Activities

  • Member of ARVO Publications Committee
  • Editorial Board Member of The Open Ophthalmology Journal


  • Associate Principal Investigator of the European Stem Cell Group- EuroSyStem
  • Association for Research in Vision and Ophthalmology (ARVO)
  • International Society for Stem Cell Research
  • Fellow Royal Society of Medicine, UK
  • British Society for Immunology, UK
  • International Society for Eye Research
Astrid Limb
Astrid Limb

Research Group

Retinal Repair and Regeneration Research Group

[more information]


UCL Institute of Ophthalmology

11-43 Bath Street
EC1V 9EL London

Phone: + 44 207 608 6974
Fax: +44 207 608 6887



Key Publications

  1. Bhatia B, Singhal S, Tadman DN, Khaw PT, Limb GA. (2010)
    SOX2 is required for adult human Muller stem cell survival and maintenance of progenicity in vitro.
    Invest Ophthalmol Vis Sci. Aug 25. [Epub ahead of print]
  2. Bhatia B, Singhal S, Lawrence JM, Khaw PT, Limb GA. (2009)
    Distribution of Müller stem cells within the neural retina: evidence for the existence of a ciliary margin-like zone in the adult human eye.
    Exp Eye Res. 89:373-382.
  3. Singhal S, Lawrence JM, Bhatia B, Kwan T, Macneil A, Ellis JS, Luthert PT, Fawcett J, Perez MT, Khaw PT, Limb GA. (2008).
    Chondroitin sulphate proteoglycans and microglia prevent migration and integration of grafted Müller stem cells into degenerating retina.
    Stem cells. 26: 1074-1082
  4. Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, Khaw PT, Limb GA. (2007).
    MIO-M1 cells and similar Müller glial cell lines derived from adult human retina exhibit neural stem cell characteristics.
    Stem cells. 25: 2033-2043
  5. Limb GA, Matter K, Murphy G, Cambrey A, Bishop P, Morris GE, Khaw PT. (2005)
    Matrix metalloproteinase-1 (MMP-1) associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis.
    Am. J. Pathol. 166: 155-1563
  6. Limb,G.A., Daniels,J.T., Pleass,R., Charteris,D.G., Luthert,P.J., Khaw,P.T. (2002).
    Differential expression of matrix metalloproteinases 2 and 9 by glial Muller cells: response to soluble and extracellular matrix-bound tumor necrosis factor-alpha.
    Am J Pathol 160(5), 1847-1855
  7. Limb GA, Salt TE, Munro PMG, Moss SE, Khaw PT. (2002)
    In Vitro Characterization of a spontaneously Immortalized Human Müller Cell Line (MIO-M1).
    Invest. Ophthal. Vis. Sci. 43: 864-869

Research Groups