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Franz Grus

Short CV


  • Habilitation and venia legendi in Experimental Ophthalmology
  • Registration as medical scientist (Approbation)
  • Graduation as Dr. med. (summa cum laude)
  • Studies in Human Medicine, RWTH Aachen, Germany
  • Graduation as Dr. rer. nat.
  • Graduation as Biologist (Diploma)
  • Studies in Biology, RWTH Aachen, Germany

Scientific Career

  • Head of the Experimental Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz
  • Research Assistant at the Dept. of Ophthalmology, University Mainz
  • Research Assistant at the Dept. of Ophthalmology, University Bonn

Habilitation in Pathophysiology of the eye

Topic: „Quantitative analysis of autoantibody-repertoires in ophthalmologic autoimmun diseases and of tear protein patterns in Sicca-syndrome“; University Medical Center of the Johannes Gutenberg University Mainz

Medical Dissertation

Topic: “A fast and easy approach for the analysis of complex autoantibody patterns“. Medical Faculty of the University Essen, Germany, Clinic of Neurology; “Summa cum laude”

Ph.D. thesis

Topic: „Electrophysiological in vivo and in vitro experiments on the kinetics of activation and inaktivation of rhodopsin in the median eye of Limulus polyphemus”. Faculty of Mathematics and Natural Sciences, RWTH Aachen, Germany; “Magna cum laude”

Diploma thesis in Biology

"Development of a computer-controlled light stimulation and measurement recording of the light response of the ventral nerve photoreceptor of Limulus and a method for micro-circulation of the external medium". Dept. of Biology II (Zoology), RWTH Aachen, Germany


CV of Franz Grus [pdf]

Franz Grus
Franz Grus

Research Group

Experimental and Translational Ophthalmology

[more information]


Johannes Gutenberg University

University Medical Center
Eye Clinic
Experimental and Translational Ophthalmology

Langenbeckstr. 1
55131 Mainz

Phone: +49-6131 173328



Scientifc Interest


  • Is there an underlying autoimmune component in the glaucoma disease?
  • Can autoantibodies serve as early-diagnosis and follow-up markers of the disease, or be used neuroprotection/ immunomodulation?

Tear film:

  • Can tear film be used for non-invasive diagnostic approaches using state of the art proteomics methods and combined bioinformatics, not only in eye diseases?

Further Activities

Reviewer for international Journals

  • Investigative Ophthalmology and Visual Sciences (IOVS)
  • Graefe’s Archives of Ophthalmology
  • Current Eye Research
  • Experimental Eye Research
  • Molecular Vision
  • American Journal of Ophthalmology
  • Proteomics
  • Electrophoresis
  • Ophthalmology


  • ARVO (Association for Research in Vision and Ophthalmology)
  • ASGCT (American Society for Gene and Cell Therapy)
  • DOG (Germany ophthalmological Society)
  • EPOS (European Pediatric Ophthalmological Society)
  • DG-GT (German Society for Gene Therapy)

Key Publications

  1. Wilding C, Bell K, Beck S, Funke S, Pfeiffer N, et al. (2014)
    gamma-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway.
    PLoS One 9: e90737.
  2. Gramlich OW, Beck S, von Thun Und Hohenstein-Blaul N, Boehm N, Ziegler A, et al. (2013)
    Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina.
    PLoS One 8: e57557.
  3. Boehm N, Funke S, Wiegand M, Wehrwein N, Pfeiffer N, et al. (2013)
    Alterations in the tear proteome of dry eye patients--a matter of the clinical phenotype.
    Invest Ophthalmol Vis Sci 54: 2385-2392.
  4. Joachim SC, Gramlich OW, Laspas P, Schmid H, Beck S, et al. (2012)
    Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens.
    PLoS One 7: e40616.
  5. Boehm N, Wolters D, Thiel U, Lossbrand U, Wiegel N, et al. (2012)
    New insights into autoantibody profiles from immune privileged sites in the eye: A glaucoma study.
    Brain Behav Immun 26: 96-102.
  6. Bell K, Funke S, Pfeiffer N, Grus FH (2012)
    Serum and antibodies of glaucoma patients lead to changes in the proteome, especially cell regulatory proteins, in retinal cells.
    PLoS One 7: e46910.
  7. Laspas P, Gramlich OW, Muller HD, Cuny CS, Gottschling PF, et al. (2011)
    Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens.
    Invest Ophthalmol Vis Sci 52: 8835-8848.
  8. Joachim SC, Reichelt J, Berneiser S, Pfeiffer N, Grus FH (2008)
    Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens.
    Graefes Arch Clin Exp Ophthalmol 246: 573-580.
  9. Joachim SC, Bruns K, Lackner K, Pfeiffer N, Grus FH (2007)
    Antibodies to alphaB-Crystallin, Vimentin, and Heat Shock Protein 70 in Aqueous Humor of patients with Normal Tension Glaucoma and IgG Antibody Patterns Against Retinal Antigen in Aqueous Humor.
    Curr Eye Res 32: 501-509.
  10. Grus FH, Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, et al. (2006)
    Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States.
    Invest Ophthalmol Vis Sci 47: 968-976.

Research Groups