Despite increasing research on myopia over the past 30 years, it is clear that myopia is still on the rise in most countries. In fact, in Singapore, Hong Kong, Shanghai, and Taiwan, myopia rates reach 95% and the “high myopias” (> 6D), carrying severe risks of chorio-retinal degeneration and blindness, reach now 20% in young people (i.e. Sun et al, IOVS 2012, 53). In Germany, a recent study shows that persons graduating from high school after 13 years are 51% myopic (Mirshahi et al, Ophthalmology 2014, 121). Myopia is a civilization disease, its recent increase is NOT due to genes, and currently proposed strategies show only small, albeit significant, effects. Therefore, in MyFUN we propose a new effort to answer some fundamental questions of myopia development and consider three targets, grouped in three overlapping research Work Packages (WP).