You are here: » People » Research Groups » Germany » Strauss, Olaf

Experimentelle Ophthamologie Regensburg

Research Group of Prof. Dr. Olaf Strauss, Regensburg, Germany.

The main interest of the Experimentelle Ophthalmologie Regensburg is the cell physiology of the retinal pigment epithelium (RPE) in health and disease. The RPE forms a functional with the photoreceptors of the eye and is essential in visual function. The failure of these functions leads to retinal degenerations or macular degenerations. We want to know how the functions of the RPE are regulated and how these regulatory mechanisms change in a chain of events leading to degenerative diseases of the retina. Using cultured cells, cell lines or animal models for retinal diseases we investigate signalling by means of changes intracellular free Ca2+regulating cell function such as phagocytosis or secretion by the RPE. Underlying protein/protein interactions are investigated by heterologeously expressed protein. The changes in the protein/protein interaction due to gene mutation can be identified in the isolated system as well in the animal. A focus is on ion channels and the regulation of ion channel activity. With the line up of the established methods the cell function is investigated from gene-expression, to regulatory mechanisms, controlling cell function and the reaction of the whole organ.


  • Molecular cloning,
  • heterologeous expression,
  • Ca2+ imaging,
  • Patch-clamp analysis of ion channels,
  • secretion assay,
  • light-damage,
  • immunoprecipiation,
  • histology


Cooperation 1:
Miguel Seabra London Imperial College

Cooperation 2:
Catherine Bowes Rickman, Duke University Durham, USA

Cooperation 3:
Bernhard Weber, Regensburg

Cooperation 4:
Ernst Tamm, Regensburg

Cooperation 5:
Andreas Reichenbach Leipzig

Group Leader

Prof. Dr. Olaf Strauss

more information


Klinik und Polklinik für Augenheilkunde
Klinikum der Universität Regensburg

Franz-Josef-Strauss Allee 11
93053 Regensburg

Phone: +49-941-9228
Fax: +49-941-9202


Experimentelle Ophthamologie Regensburg

Current Research Projects

Project 1:
Function of bestrophin-1 and the mechanisms leading to Best’s disease

Project 2:
Choroidal neovascularisation in age-related macular degeneration

Project 3:
Interaction between rab-proteins and ioin channels

Project 4:
Communication between Müller cells and RPE cells

Research Groups


Related Research Groups

age-related macular degeneration
Oops, an error occurred! Code: 2020092600200195e6eff7
Oops, an error occurred! Code: 2020092600200170909418
choroid: neovascularization
Oops, an error occurred! Code: 20200926002001b48fdf1e
growth factors/growth factor receptors
Oops, an error occurred! Code: 20200926002001a465d6d7
ion channels
Oops, an error occurred! Code: 2020092600200103a48147
retinal degenerations: cell biology
Oops, an error occurred! Code: 2020092600200172a0d420
retinal degenerations: hereditary
Oops, an error occurred! Code: 2020092600200121454016
retinal pigment epithelium
Oops, an error occurred! Code: 20200926002001740fe136
signal transduction: pharmacology/physiology
Oops, an error occurred! Code: 20200926002001096c251e
Best’s disease
Oops, an error occurred! Code: 2020092600200167adaafa
Cell physiology
Oops, an error occurred! Code: 2020092600200112e0a49e
Protein/protein interaction
Oops, an error occurred! Code: 20200926002001942f38aa
Photoreceptor outer segment phagocytosis
Oops, an error occurred! Code: 20200926002001d982db21
Free radicals
Oops, an error occurred! Code: 2020092600200159ae5254