Research Group of Prof. Dr. Olaf Strauss, Regensburg, Germany.
The main interest of the Experimentelle Ophthalmologie Regensburg is the cell physiology of the retinal pigment epithelium (RPE) in health and disease. The RPE forms a functional with the photoreceptors of the eye and is essential in visual function. The failure of these functions leads to retinal degenerations or macular degenerations. We want to know how the functions of the RPE are regulated and how these regulatory mechanisms change in a chain of events leading to degenerative diseases of the retina. Using cultured cells, cell lines or animal models for retinal diseases we investigate signalling by means of changes intracellular free Ca2+regulating cell function such as phagocytosis or secretion by the RPE. Underlying protein/protein interactions are investigated by heterologeously expressed protein. The changes in the protein/protein interaction due to gene mutation can be identified in the isolated system as well in the animal. A focus is on ion channels and the regulation of ion channel activity. With the line up of the established methods the cell function is investigated from gene-expression, to regulatory mechanisms, controlling cell function and the reaction of the whole organ.
Miguel Seabra London Imperial College
Catherine Bowes Rickman, Duke University Durham, USA
Bernhard Weber, Regensburg
Ernst Tamm, Regensburg
Andreas Reichenbach Leipzig
Prof. Dr. Olaf Strauss
Function of bestrophin-1 and the mechanisms leading to Best’s disease
Choroidal neovascularisation in age-related macular degeneration
Interaction between rab-proteins and ioin channels
Communication between Müller cells and RPE cells