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Retinal circuit function group

Research group of Dr. Botond Roska in Basel, Switzerland.

Our group is interested to understand the structure and function of retinal circuits in health and disease. We use genetic technologies to label and manipulate different cell types in the retina, transsynaptic viruses to understand neuronal connectivity, two photon microscopy, electrophysiology and behavioural assays to read out retinal circuit function.

Methodology

  • Generation of knock-in, transgenic and BAC transgenic mice.
  • Viral tools: AAVs, pseudorabies and rabies tracer viruses.
  • 2P microscopy, electrophysiology and behavioural studies.

Cooperations

Cooperation 1:
Constance Cepko, Department of Genetics, Harvard Medical School

Cooperation 2:
Lynn Enquist, Princeton University

Cooperation 3:
Zsolt Boldogkoi, University of Szeged

Cooperation 4:
Jose Sahel, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts

Current Research Projects

Project 1:
Restoring retinal function in retinal degeneration by cell type specific targetting of optogenetic tools.    

Project 2:
Unserstanding the structure and function of an approach sensitive neural circuit in the mammalian retina    

Project 3:
Genetic and physiological study of the rod circuit: the function of A17 amacrine cells.    

Project 4:
Functional role of amacrine cells in the circuit of intrinsically photosensitive ganglion cells.    

Project 5:
Retinal processing at bipolar cell axon terminals.   

Group Leader

Dr. Botond Roska

more information

Contact

Friedrich Miescher Institute

Maulbeerstrasse 66
4058 Basel
Switzerland

Phone: +41 (61) 69 78 575
Fax: +41 (61) 697-3976

Email: botond.roska[at]fmi.ch
Website: Botond Roska / Neurobiology

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