You are here: vision-research.eu » People » Research Groups » Netherlands » Wijnholds, Jan

Neuromedical Genetics

Research group of Dr. Jan Wijnholds in Amsterdam, Netherlands.

The research team studies the role of the Crumbs (CRB) protein complex in preventing onset of Retinitis Pigmentosa and Leber congenital amaurosis. Loss of CRB1 protein results in loss of adhesion between Müller glia cells and photoreceptors. The physiological and cell biological roles of members of the  CRB complex are studied. The team develops AAV gene therapy for clinical use, and explores retinal progenitor cell transplantation to test its suitability for future clinical use.

Methodology

  • Gene Therapy,
  • AAV, Adeno-Associated-Virus,
  • Gene silencing
  • Conditional knock-out, knock-in and knock-down mice
  • Scanning-laser-ophthalmoscopy (SLO),
  • Biochemistry

Cooperations

Cooperation 1:
Crumbs In Sight
(http://www.retina.fr/crumbs)

Cooperation 2:
André Le Bivic
(http://www.ibdml.univ-mrs.fr)

Cooperation 3:
Mathias Seeliger
(http://www.neuroscience-tuebingen.de)

Cooperation 4:
Frans Cremers
(http://www.ncmls.nl/NCMLS)

Cooperation 5:
AMT
(www.amtbiopharma.com)

Group Leader

Dr. Jan Wijnholds

more information

Contact

Netherlands Institute for Neuroscience (NIN)
Royal Netherlands Academy of Arts and Sciences (KNAW)

Meibergdreef 47
1105 BA Amsterdam
The Netherlands

Phone: +31-20-5664597
Fax: +31-20-5666121

Email: j.wijnholds[at]nin.knaw.nl
Website www.nin.knaw.nl/NMG

Current Research Projects

Project 1:
Gene therapy to fight Leber congenital amaurosis due to loss of CRB1 function

Project 2:
Generation and analysis of retinas and other tissues lacking a functional Crb3 and Crb1 gene

Project 3:
Generation and analysis of retinas and other tissues lacking a functional Pals1 gene

Project 4:
Studying establishment and maintenance of Müller glia cell – photoreceptor interaction, and development of Müller glia progenitor cell therapy

Project 5:
Stress-inducible AAV6-mediated neurotrophic factor therapy for Crumbs-related eye diseases

Research Groups

People

Related Research Groups

cell adhesions/cell junctions
Oops, an error occurred! Code: 2019101709292085842e7a
gene transfer/gene therapy
Oops, an error occurred! Code: 201910170929206d07204f
Leber congenital amaurosis, Muller cells
Oops, an error occurred! Code: 2019101709292014723478
photoreceptors
Oops, an error occurred! Code: 20191017092920eb608865
protein structure/function
Oops, an error occurred! Code: 20191017092920931bac4e
proteins encoded by disease genes
Oops, an error occurred! Code: 2019101709292021040a3e
retinal degenerations: cell biology
Oops, an error occurred! Code: 2019101709292048b6c4c0
retinal degenerations: hereditary
Oops, an error occurred! Code: 2019101709292015fa8f44
retinitis pigmentosa
Oops, an error occurred! Code: 2019101709292056699442
synapse
Oops, an error occurred! Code: 20191017092920fe0f3c8d
transgenics/knock-outs
Oops, an error occurred! Code: 20191017092920bfb0d373
Hereditary disease
Oops, an error occurred! Code: 201910170929202a2e4ac9
Retinal degeneration
Oops, an error occurred! Code: 201910170929200cea9661
Gene therapy
Oops, an error occurred! Code: 20191017092920516d139c
Retinal progenitor cell transplantation
Oops, an error occurred! Code: 20191017092920f98ce084
AAV
Oops, an error occurred! Code: 201910170929207dadb0ed