You are here: vision-research.eu » People » Research Groups » Netherlands » Wijnholds, Jan

Neuromedical Genetics

Research group of Dr. Jan Wijnholds in Amsterdam, Netherlands.

The research team studies the role of the Crumbs (CRB) protein complex in preventing onset of Retinitis Pigmentosa and Leber congenital amaurosis. Loss of CRB1 protein results in loss of adhesion between Müller glia cells and photoreceptors. The physiological and cell biological roles of members of the  CRB complex are studied. The team develops AAV gene therapy for clinical use, and explores retinal progenitor cell transplantation to test its suitability for future clinical use.

Methodology

  • Gene Therapy,
  • AAV, Adeno-Associated-Virus,
  • Gene silencing
  • Conditional knock-out, knock-in and knock-down mice
  • Scanning-laser-ophthalmoscopy (SLO),
  • Biochemistry

Cooperations

Cooperation 1:
Crumbs In Sight
(http://www.retina.fr/crumbs)

Cooperation 2:
André Le Bivic
(http://www.ibdml.univ-mrs.fr)

Cooperation 3:
Mathias Seeliger
(http://www.neuroscience-tuebingen.de)

Cooperation 4:
Frans Cremers
(http://www.ncmls.nl/NCMLS)

Cooperation 5:
AMT
(www.amtbiopharma.com)

Group Leader

Dr. Jan Wijnholds

more information

Contact

Netherlands Institute for Neuroscience (NIN)
Royal Netherlands Academy of Arts and Sciences (KNAW)

Meibergdreef 47
1105 BA Amsterdam
The Netherlands

Phone: +31-20-5664597
Fax: +31-20-5666121

Email: j.wijnholds[at]nin.knaw.nl
Website www.nin.knaw.nl/NMG

Current Research Projects

Project 1:
Gene therapy to fight Leber congenital amaurosis due to loss of CRB1 function

Project 2:
Generation and analysis of retinas and other tissues lacking a functional Crb3 and Crb1 gene

Project 3:
Generation and analysis of retinas and other tissues lacking a functional Pals1 gene

Project 4:
Studying establishment and maintenance of Müller glia cell – photoreceptor interaction, and development of Müller glia progenitor cell therapy

Project 5:
Stress-inducible AAV6-mediated neurotrophic factor therapy for Crumbs-related eye diseases

Research Groups

People

Related Research Groups

cell adhesions/cell junctions
Oops, an error occurred! Code: 20191212094259b412c915
gene transfer/gene therapy
Oops, an error occurred! Code: 20191212094259def6a3d7
Leber congenital amaurosis, Muller cells
Oops, an error occurred! Code: 20191212094259f7910ff8
photoreceptors
Oops, an error occurred! Code: 201912120942595a6b72f1
protein structure/function
Oops, an error occurred! Code: 20191212094259e883c8c6
proteins encoded by disease genes
Oops, an error occurred! Code: 201912120942594db7e12d
retinal degenerations: cell biology
Oops, an error occurred! Code: 201912120942598b3f2eae
retinal degenerations: hereditary
Oops, an error occurred! Code: 20191212094259d8dbc8af
retinitis pigmentosa
Oops, an error occurred! Code: 201912120942597d3a7173
synapse
Oops, an error occurred! Code: 20191212094259216e9dec
transgenics/knock-outs
Oops, an error occurred! Code: 2019121209425985c8d93d
Hereditary disease
Oops, an error occurred! Code: 20191212094259d716dbae
Retinal degeneration
Oops, an error occurred! Code: 201912120942595664d2ca
Gene therapy
Oops, an error occurred! Code: 201912120942597cc13670
Retinal progenitor cell transplantation
Oops, an error occurred! Code: 201912120942592d832e11
AAV
Oops, an error occurred! Code: 20191212094259491e2ab9