Research group of Dr. Jan Wijnholds in Amsterdam, Netherlands.
The research team studies the role of the Crumbs (CRB) protein complex in preventing onset of Retinitis Pigmentosa and Leber congenital amaurosis. Loss of CRB1 protein results in loss of adhesion between Müller glia cells and photoreceptors. The physiological and cell biological roles of members of the CRB complex are studied. The team develops AAV gene therapy for clinical use, and explores retinal progenitor cell transplantation to test its suitability for future clinical use.
Crumbs In Sight
André Le Bivic
Dr. Jan Wijnholds
Netherlands Institute for Neuroscience (NIN)
Royal Netherlands Academy of Arts and Sciences (KNAW)
1105 BA Amsterdam
Gene therapy to fight Leber congenital amaurosis due to loss of CRB1 function
Generation and analysis of retinas and other tissues lacking a functional Crb3 and Crb1 gene
Generation and analysis of retinas and other tissues lacking a functional Pals1 gene
Studying establishment and maintenance of Müller glia cell – photoreceptor interaction, and development of Müller glia progenitor cell therapy
Stress-inducible AAV6-mediated neurotrophic factor therapy for Crumbs-related eye diseases