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Ophthalmogenetics

Research Group of Prof. Dr. Frans Cremers in Nijmegen, Netherlands.

The ophthalmogenetic research group aims to identify the majority of causal genes for retinal dystrophies, to elucidate their cellular function, and to facilitate routine molecular diagnostics and therapy. To achieve this aim, we study the molecular causes of cone (rod) dystrophies, Leber congenital amaurosis, macular dystrophy, and retinitis pigmentosa. We also study a spectrum of vitreoretinopathies, such as familial exudative vitreoretinopathy, Wagner disease, and rhegmatogenous retinal detachment.

In the Department of Human Genetics, we collaborate with drs. H. Kremer and R. Roepman, who lead workgroups in the deaf-blindness and blindness functional genomics areas.

Methodology

  • Homozygosity mapping using whole-genome SNP arrays
  • Quantitative RT-PCR
  • Genetic linkage studies

Cooperations

Cooperation 1:
Dr. R.K. Koenekoop, Montreal

Cooperation 2:
Mrs. Dr. L.I. van den Born, Rotterdam

Cooperation 3:
Mrs. Dr. C. Klaver, Rotterdam

Cooperation 4:
Dr. K. Rohrschneider, Heidelberg

Cooperation 5:
Dr. B. Leroy, mrs. dr. E. de Baere, Ghent

Cooperation 6:
Dr. D. Sharon, Jerusalem

Cooperation 7:
Dr. S. Banfi, Napels

Cooperation 8:
Dr. R. Allikemts, New York

Cooperation 9:
Dr. E.A. Pierce, Philadelphia

Current Research Projects

Project 1:
Homozygosity Mapping in Patients with Autosomal Recessive Retinal Dystrophies

Project 2:
Elucidation of the Molecular basis of Retinal Detachment, Familial Exudative Vitreoretinopathy, and Wagner Disease

Project 3:
Genetic Causes of Macular Degeneration

Group Leader

Prof. Dr. Frans Cremers

more information

Contact

Department of Human Genetics,
Radboud University Nijmegen Medical Centre,
Nijmegen Centre for Molecular Life Sciences

Geert Grooteplein 10
6500 HB Nijmegen
The Netherlands

Phone: +31-24-3614017
Fax: +31-24-3668752

Email: f.cremers[at]antrg.umcn.nl

Websites:

Recommended Links

  • www.sph.uth.tmc.edu/RetNet
  • www.evi-genoret.org
  • www.asperophthalmics.com

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