You are here: » People » Research Groups » France » Hicks, David

Circadian clocks and retinal pathophysiology

Research group of Dr. David Hicks in Strasbourg, France.

A small team composed of three tenured scientists (Dr. David Hicks, INSERM Research Dr. Director, Head of Group; Dr. Marie-Paule Felder-Schmittbuhl, CNRS Associate Professor; Virginie Gydé-Laurent, University Lecturer), one postdoctoral student (Dr. Cristina Sandu, molecular biologist), four thesis students (Corina Bobu, Domitille Boudard, Diana Karnas, Ouafa Ait-Hmyed) and two technicians (Jean-Georges Lorentz, Claudine Boissier).


  • Molecular biology (RT- and real-time PCR, PCR cloning, transfection, gene reporter assays, genotyping)
  • Immunochemistry (immunohistochemistry, immunoblots, immunoprecipitation, apoptosis assay, RIA, ELISA)
  • Cell and tissue culture (preparative biochemistry, bioassays, cell survival assays)


Cooperation 1:
Dr. Anand Swaroop (NEI/NIH, Bethesda, MD USA). Regulation and role of Nrl in photoreceptor function.

Cooperation 2:
Dr. Gregory Hageman, Dept. Ophthalmology, Univ. Iowa, IA USA. Complement-mediated therapies for Age-Related Macular Degeneration; Cell biology of aging and disease in the human retina.

Cooperation 3:
Dr. Janet Sparrow (Columbia Univ. Med. School, New York NY USA) Characterisation of lipid accumulation during aging: use of cone-rich animal models.

Cooperation 4:
Dr. Josseline Kaplan (INSERM U. 381, Paris France). Transgenic cone-rich animal models of Stargardt’s Disease.

Cooperation 5:
Dr. Mathias Seeliger (Inst. Ophthalmic Res., Tubingen Germany) Functional correlates of retinal degeneration in cone-rich rodents.

Group Leader

Dr. David Hicks

more information


Institute of Cellular and Integrative Neurosciences

Department of Neurobiology of Rhythms, CNRS UMR 7168/LC
25 rue Blaise Pascal
67084 Strasbourg

Phone: 33 388 456 723

Email: photoreceptor67[at]

Current Research Projects

Project 1:
Molecular characterisation of circadian clock in rod photoreceptors

Project 2:
Circadian regulation of photoreceptor renewal

Project 3:
Cone phagocytosis

Project 4:
Cone phototoxicity

Project 5:
Role of melatonin in retinal function

Research Groups


Related Research Groups

age-related macular degeneration
Oops, an error occurred! Code: 2020092502155076012e3a
circadian rhythms
Oops, an error occurred! Code: 20200925021550df0d2a1d
Oops, an error occurred! Code: 20200925021550eba43f1b
ganglion cells
Oops, an error occurred! Code: 20200925021550f4ca3ed6
growth factors/growth factor receptors
Oops, an error occurred! Code: 2020092502155003f4f4fc
Oops, an error occurred! Code: 20200925021550eb723355
Oops, an error occurred! Code: 20200925021550364b8cbb
Oops, an error occurred! Code: 202009250215508c89e4b4
retinal degenerations: cell biology
Oops, an error occurred! Code: 20200925021550d63d515e
retinal pigment epithelium
Oops, an error occurred! Code: 202009250215501850147d
Circadian rhythms
Oops, an error occurred! Code: 20200925021550759b958a
Oops, an error occurred! Code: 202009250215502f9483bf
Retinal Degeneration
Oops, an error occurred! Code: 2020092502155020b361e5
Signalling Pathways
Oops, an error occurred! Code: 202009250215506fa7bad3
Transcription Factors
Oops, an error occurred! Code: 202009250215506766a111