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Circadian clocks and retinal pathophysiology

Research group of Dr. David Hicks in Strasbourg, France.

A small team composed of three tenured scientists (Dr. David Hicks, INSERM Research Dr. Director, Head of Group; Dr. Marie-Paule Felder-Schmittbuhl, CNRS Associate Professor; Virginie Gydé-Laurent, University Lecturer), one postdoctoral student (Dr. Cristina Sandu, molecular biologist), four thesis students (Corina Bobu, Domitille Boudard, Diana Karnas, Ouafa Ait-Hmyed) and two technicians (Jean-Georges Lorentz, Claudine Boissier).

Methodology

  • Molecular biology (RT- and real-time PCR, PCR cloning, transfection, gene reporter assays, genotyping)
  • Immunochemistry (immunohistochemistry, immunoblots, immunoprecipitation, apoptosis assay, RIA, ELISA)
  • Cell and tissue culture (preparative biochemistry, bioassays, cell survival assays)

Cooperations

Cooperation 1:
Dr. Anand Swaroop (NEI/NIH, Bethesda, MD USA). Regulation and role of Nrl in photoreceptor function.

Cooperation 2:
Dr. Gregory Hageman, Dept. Ophthalmology, Univ. Iowa, IA USA. Complement-mediated therapies for Age-Related Macular Degeneration; Cell biology of aging and disease in the human retina.

Cooperation 3:
Dr. Janet Sparrow (Columbia Univ. Med. School, New York NY USA) Characterisation of lipid accumulation during aging: use of cone-rich animal models.

Cooperation 4:
Dr. Josseline Kaplan (INSERM U. 381, Paris France). Transgenic cone-rich animal models of Stargardt’s Disease.

Cooperation 5:
Dr. Mathias Seeliger (Inst. Ophthalmic Res., Tubingen Germany) Functional correlates of retinal degeneration in cone-rich rodents.

Group Leader

Dr. David Hicks

more information

Contact

Institute of Cellular and Integrative Neurosciences

Department of Neurobiology of Rhythms, CNRS UMR 7168/LC
25 rue Blaise Pascal
67084 Strasbourg
France

Phone: 33 388 456 723

Email: photoreceptor67[at]hotmail.com
Website: inci.u-strasbg.fr/dept_a/equ_a1.html

Current Research Projects

Project 1:
Molecular characterisation of circadian clock in rod photoreceptors

Project 2:
Circadian regulation of photoreceptor renewal

Project 3:
Cone phagocytosis

Project 4:
Cone phototoxicity

Project 5:
Role of melatonin in retinal function

Research Groups

People

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age-related macular degeneration
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growth factors/growth factor receptors
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retinal degenerations: cell biology
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retinal pigment epithelium
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Circadian rhythms
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Signalling Pathways
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Transcription Factors
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