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Vision Institute – Department of Development

Analysis of molecular mechanisms involved in retinal progenitor cell differentiation: application to cell therapy for retinal degeneration

Research group of Dr. Olivier Goureau in Paris, France.

Due to the ability of retinal stem cells and progenitors to differentiate in any retinal cell type, theses cells are considered as a promising way to cure retinal dystrophies and to restore visual function. To achieve a complete photoreceptor differentiation, mechanisms by which differentiation occur during retinal development has to be further elucidated. This characterization is evaluated in our group by analysis of transcriptome modifications during normal development and subsequent to alteration of photoreceptor differentiation.

Methodology

  • Subtractive libraries – DNA chips
  • Gene transfer (electroporation, avian retrovirus)
  • Embryonic and post-natal retinal explants cultures

Cooperations

Cooperation 1:
Integrated Project - European Commission: FP6 (Functional genomics): Derivation and characterization of stem cells with therapeutic potentiel (Dr Marigo , Modène ; Dr Vescovi – Dr Fiocco, Milan)

Cooperation 2:
Analysis of retinal development in Sema6- and HB9 knock-out mice (Dr A. Chédotal, Vision Institute)

Group Leader

Dr. Olivier Goureau

more information

Contact

INSERM

Institut de la Vision
17 rue Moreau
75012 Paris
France

Phone: +33-1-53-462550
Fax: +33-1-53-462601

Email: olivier.goureau[at]inserm.fr
Website: Olivier Goureau / Vision Institute

Current Research Projects

Project 1:
Role of Ptf1a and Foxn4 in the differentiation of amacrine and horizontal cells by a retroviral approach in chick retina.

Project 2:
Identification of CNTF-regulated genes involved in photoreceptor differentiation by DNA chip technology

Project 3:
Analysis of retinal progenitor lineage after over-expression or invalidation of selected genes by electroporation in post-natal rodent retinal explants.

Research Groups

People

Related Research Groups

differentiation
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gene/expression
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gene transfer/gene therapy
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microscopy: light/fluorescence/immunohistochemistry
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photoreceptors
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retina
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retinal culture
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retinal development
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signal transduction
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transcription factors
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