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Ana Griciuc

Current Research Projects

ER stress and apoptotic cell death in the retina occurs as a consequence of impaired turnover of mutant Rhodopsin via activation of stress-specific JNK and p38 mitogen-activated protein kinases. We proved that the absence of ERAD members significantly diminishes Rhodopsin-induced activation of JNK. We also showed that ERAD is important in the degradation and aggregation of both wild type and mutant Rhodopsin.

Methodology

Within my research project we used Drosophila as genetic tool. We also performed knock-down in mammalian cell lines (RNAi, sh-RNA), WB, SDS-PAGE/2D-Electrophoresis/MALDI-TOF-MS and fluorescence microscopy.

Research Group

Department of Protein Science

Contact

Helmholtz Zentrum München
German Research Center for Environmental Health

Ingolstaedter Landstrasse 1,
Buiding 35 Room 8125
85764 Neuherberg-Munich
Germany

Phone: +49-89 3187 3526
Fax: +49-89 3187 4426

Email:
Ana.griciuc[at]helmholtz-muenchen.de

Website:
www.helmholtz-muenchen.de

Documents

CV of Ana Griciuc [pdf]

Research Groups

People

Related Research Groups

aging: visual performance
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antioxidants
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apoptosis/cell death
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cell survival
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chaperones
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growth factors/growth factor receptors
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immunohistochemistry
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mitochondria
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opsins
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retinitis pigmentosa
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stress response
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