You are here: vision-research.eu » People » Young Researcher » Sahaboglu, Ayse

Ayse Sahaboglu

Current Research Projects

My research focuses on the molecular mechanism of photoreceptor degeneration with the goal of identifying new markers and therapeutic targets. I am involved in the preclinical developments of drugs for inherited photoreceptor degeneration (www.drugsford.eu).

I am also interested in the role of poly (ADP-ribose) polymerase (PARP) and poly (ADP-ribose) glycohydrolase (PARG) in retinal degeneration.

Methodology

  • In vivo injection methods (intravitreal, intraperitoneal, intravenous, subcutaneous)
  • Organotypic retinal culture
  • Western blot
  • Immunofluorescence, immunohistochemistry
  • in situ biochemical assays
Ayse Sahaboglu
Ayse Sahaboglu

Research Group

Division of Experimental Ophthalmology

Contact

University of Tuebingen
Institute for Ophthalmic Research

Roentgenweg 11
72076 Tuebingen
Germany

Phone: +49 (0) 7071 29 84781
Fax: +49 (0) 7071 29 5777

Email:
ayse.sahaboglu-tekgoez[at]klinikum.uni-tuebingen.de

Selected Publications

  1. Sahaboglu A, Tanimoto N, Bolz B, Garcia Garrido M,  Ueffing M, Seeliger MW, Löwenheim H,  Ekström P, Paquet-Durand F. (2014)
    Knockout of PARG110 confers resistance to cGMP induced toxicity in mammalian photoreceptors.
    Cell Death and Disease. doi: 10.1038/cddis.2014.208.
  2. Sahaboglu A, Bolz S, Lowenheim H, Paquet-Durand F (2014)
    Expression of Poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.
    Adv Exp Med Biol.  doi: 10.1007/978-1-4614-3209-8_59.
  3. Paquet-Durand F, Sahaboglu A, Dietter J, Paquet-Durand O, Hitzmann B, Ueffing M,  Ekström P (2014)
    How long does a photoreceptor cell take to die? Implications for the causative cell death mechanisms.
    Adv Exp Med Biol.  Doi:10.1007/978-1-4614-3209-8_73.
  4. Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB. (2013)
    Inhibition of mitochondrial pyruvate transport by Zaprinast causes massive accumulation of aspartate at the expense of glutamate in retinas.
    The Journal of Biological Chemistry. Doi: 10.1074/jbc.M113.507285
  5. Sahaboglu A, Paquet-Durand O, Dengler K, Bernhard-Kurz S, Hitzmann B, Ueffing M, Paquet-Durand F. (2013)
    Retinitis Pigmentosa: Rapid neurodegeneration is governed by slow cell death mechanisms.
    Cell Death and Disease. doi:10.1038/cddis.2013.12
  6. Trifunović D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F. (2012)
    Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration.
    Curr Mol Med. 12(5):598-612.
  7. Kaur J, Mencl S, Sahaboglu A, van Veen T, Zrenner E, Ekstrom P, Paquet Durand F, Arango-Gonzalez B. (2011)
    Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats.
    PLoS ONE. 6 (7):e22181.
  8. Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F. (2010)
    PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
    PLoS ONE 5(11): e15495.
  9. Sancho-Pelluz J, Alavi M, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P. (2010)
    Excessive HDAC activation critical for neurodegeneration in the rd1 mouse.
    Cell Death & Disease, doi:10.1038/cddis.2010.4.
  10. Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz, A, Paquet-Durand F, Wenzel A, Seeliger MW, Fischer MD. (2009)
    Spectral domain optical coherence tomography in mouse models of retinal degeneration.
    Investigative Ophthalmology & Visual Science 50(12):5888-5995.
  11. Dilsiz N, Sahaboglu A, Yıldız MZ, and Reichenbach A. (2006)
    Protective effects of various antioxidants during ischemia-reperfusion in the rat retina.
    Graefe’s Archive for Clinical and Experimental Ophthalmology 244 (5): 627-633.

Research Groups

People

Related Research Groups

antioxidants
Berendschot, Tos
Chakravarthy, Usha
Griciuc, Ana
Johnsen-Soriano, Siv
Kustermann, Stefan
Miranda Sanz, María
Paquet-Durand, Francois
Tsilimbaris, Miltiadis
Romero, Francisco Javier
Sancho-Pelluz, Javier
van Veen, Theo
cell survival
Ader, Marius
Andrés-Guerrero, Vanessa
Bovolenta, Paola
Calonge, Margarita
Cottet, Sandra
De la Rosa, Enrique
Griciuc, Ana
Grimm, Christian
Humphries, Peter
Martin, Keith
Miranda Sanz, María
Paquet-Durand, Francois
Picaud, Serge
Sancho-Pelluz, Javier
Thanos, Solon
immunohistochemistry
Ader, Marius
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Calonge, Margarita
Coupland, Sarah
Dedek, Karin
Dedek, Karin
Ekström, Per
Goureau, Olivier
Griciuc, Ana
Grus, Franz
Heiduschka, Peter
Jager, Martine
Joachim, Stephanie
Julien, Sylvie
Kennedy, Breandan
Kustermann, Stefan
Limb, Astrid
Lütjen-Drecoll, Elke
Marigo, Valeria
Neuhauss, Stephan
O'Driscoll, Ciara
Palfi, Arpad
Reinhard, Thomas
Sennlaub, Florian
Roepman, Ronald
Sancho-Pelluz, Javier
Strettoi, Enrica
van Veen, Theo
Vitanova, Liliya
Wässle, Heinz
Wolfrum, Uwe
neuroprotection
Andrés-Guerrero, Vanessa
Arango-Gonzalez, Blanca
Auricchio, Alberto
Chadderton, Naomi
Cordeiro, M Francesca
Cottet, Sandra
Ekström, Per
Enzmann, Volker
Grimm, Christian
Grus, Franz
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Humphries, Peter
Joachim, Stephanie
Karl, Mike O.
Kremers, Jan
Kustermann, Stefan
Lagreze, Wolf
Martin, Keith
Miranda Sanz, María
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Romero, Francisco Javier
Sancho-Pelluz, Javier
Scanlon, Peter
Skorkovská, Karolína
Ueffing, Marius
van Veen, Theo
Zrenner, Eberhart
photoreceptors
Ader, Marius
Arango-Gonzalez, Blanca
Arden, Geoffrey
Artal, Pablo
Auricchio, Alberto
Baraas, Rigmor
Berendschot, Tos
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Bujakowska, Kinga
Cangiano, Lorenzo
Chadderton, Naomi
Cottet, Sandra
Dell'Orco, Daniele
Ekström, Per
Goureau, Olivier
Heiduschka, Peter
Hicks, David
Julien, Sylvie
Kamermans, Maarten
Kawasaki, Aki
Kennedy, Breandan
Kremers, Jan
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Marigo, Valeria
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Sancho-Pelluz, Javier
Strettoi, Enrica
Ueffing, Marius
van Veen, Theo
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Zeitz, Christina
protective mechanisms
Cottet, Sandra
retina: neurochemistry , retinal culture , retinal degenerations: hereditary , retinitis pigmentosa
Ader, Marius
Arango-Gonzalez, Blanca
Arden, Geoffrey
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Banfi, Sandro
Baraas, Rigmor
Bergen, Arthur
Berger, Wolfgang
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cottet, Sandra
Cremers, Frans
De la Rosa, Enrique
den Hollander, Anneke
Dollfus, Hélène
Ekström, Per
Enzmann, Volker
Fighting Blindness
Goureau, Olivier
Graw, Jochen
Griciuc, Ana
Grus, Franz
Hamel, Christian ✝
Inglehearn, Chris
Kennedy, Breandan
Kustermann, Stefan
Langmann, Thomas
Larsen, Michael
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
Martin, Keith
Moore, Tony
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Pastor, Jose-Carlos
Petersen, Michael
Picaud, Serge
Reichenbach, Andreas
Sennlaub, Florian
Tsilimbaris, Miltiadis
Rivolta, Carlo
Roepman, Ronald
Romero, Francisco Javier
Sancho-Pelluz, Javier
Schimpf-Linzenbold, Simone
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
Tejedor-Fraile, Jaime
Thanos, Solon
van Veen, Theo
Vitanova, Liliya
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Wright, Alan
Zrenner, Eberhart

Missing some information on vision-research.eu?

* mandatory field