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Veronica van Heyningen

Scientifc Interest

  • Mechanisms of genetic disease
  • Gene interactions, cis-regulatory control of gene expression
  • Developmental control
  • Gene networks
  • Phenotype modulation

Memberships

  • ESHG
  • ASHG
  • Biochemical Society
  • EMBO

Fellow

  • Royal Society
  • Royal Society of Edinburgh
  • Academy of Medical Sciences

Key Publications

  1. Yeyati Pl, Van Heyningen V.
    Incapacitating the evolutionary capacitor: Hsp90 modulation of disease.
    Curr Opin Genet Dev. 18: 264-272, 2008
  2. Kleinjan Da, Bancewicz Rm, Gautier P, Dahm R, Schonthaler Hb, Damante G, Seawright A, Hever Am, Yeyati Pl, Van Heyningen V and Coutinho P.
    Subfunctionalisation of duplicated zebrafish pax6 genes by cis-regulatory divergence.
    PLoS Genetics,4: e29, 2008
  3. Robinson Do, Howarth Rj, Williamson Ka, Van Heyningen V, Beal Sj And Crolla JA.
    Genetic analysis of Chromosome 11p13 and the PAX6 gene in a series of 125 cases referred with aniridia.
    Am J Med Genet 146A: 558-569, 2008
  4. Hewitt Aw, Kearns Ls, Jamieson Rv, Williamson Ka, Van Heyningen V, Mackey DA.
    PAX6 Mutations may be associated with high myopia.
    Ophthalmic Genet. 28: 179-182, 2007
  5. Van Heyningen V, Hoovers Jmn, De Kraker J, Crolla JA.
    Elevated risk of Wilms tumour in aniridia cases with submicroscopic WT1 deletion.
    J Med Genet 44: 787-790, 2007
  6. Henderson A, Williamson K, Cumming S, Clarke M, Lynch Sa, Hanson Im, Fitzpatrick D, Sisodiya S, Van Heyningen V.
    Inherited PAX6, NF1 and OTX2 mutations in a child with microphthalmia and aniridia Eur
    J Hum Genet 15: 898-901, 2007
  7. Bamiou De, Free Sl, Sisodiya Sm, Chong Wk, Musiek F, Williamson Ka, Van Heyningen V, Moore At, Gadian D, Luxon LM.
    Auditory interhemispheric transfer deficits, hearing difficulties and brain MRI abnormalities in children with congenital aniridia due to a PAX6 mutation.
    Arch Pediatr Adolesc Med. 161: 463-469, 2007
  8. Yeyati Pl, Bancewicz Rm, Maule J And Van Heyningen V.
    HSP90 selectively modulates phenotype in vertebrate development.
    PLoS Genetics, 3: e43, 2007
  9. Manuel M, Georgala Pa. Carr Cb, Chanas S, Kleinjan Da, Martynoga B, Mason Jo, Molinek M, Pinson J, Pratt T, Quinn Jc, T. Simpson I, Tyas Da, Van Heyningen V, West Jd, Price Dj.
    Controlled overexpression of Pax6 in vivo negatively auto-regulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization.
    Development 134: 545-555, 2007
  10. Kleinjan Da, Seawright A, Mella S, Carr Cb, Tyas Da, Simpson Ti, Mason Jo, Price Dj, Van Heyningen V.
    Long-range downstream enhancers are essential for Pax6 expression.
    Dev Biol. 299: 563-581, 2006
Veronica van Heyningen
Veronica van Heyningen

Research Group

van Heyningen group – developmental eye anomalies

Contact

MRC Human Genetics Unit

Western General Hospital
Crewe Road
EH4 2XU EDINBURGH
United Kingdom

Phone: 0131 332 2471
Fax: 0131 467 8456

Email:
v.vanheyningen[at]hgu.mrc.ac.uk

Website:
www.hgu.mrc.ac.uk/Research/VanHeyningen/

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