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Laboratory of Molecular Eye Development

Mouse mutants affecting eye development and the function of ocular tissues are being characterized in a molecular, functional and morphological manner. Several screens are established to identify new mutants; these screens include Scheimpflug analysis of lens opacities, optical coherence tomography (OCT), eye-size measurements by laser interference biometry, and the virtual optokinetic drum.

New mutations are mapped and molecularly characterized.

Established mutants are characterized in detail under the umbrella of the German Mouse Clinic (GMC; www.mouseclinic.de/).

Additionally, we are characterizing also families suffering from cataracts; we are also involved in the epidemiology of eye diseases within the framework of KORA.

Methodology

  • Vision tests for the mouse: Scheimpflug analysis of lens opacities, optical coherence tomography (OCT), electroretinography, eye-size measurements by laser interference biometry, and the virtual optokinetic drum.
  • Histology
  • Linkage analysis of mouse mutants

Scientific Cooperations

  • Cooperation 1:
    Within the Helmholtz Center Munich: Institute of Experimental Genetics (German Mouse Clinic: Prof. Hrabé de Angelis)
  • Cooperation 2:
    Within the Helmholtz Center Munich: Institute of Epidemiology II (Prof. Peters)
  • Cooperation 3:
    India: University of Madras (Prof. Santhiya); University of Manipal (Prof. Gopinath)

Group Leader

Jochen Graw
[more information]

Contact

Helmholtz Center Munich

German Research Center for Environmental HealthInstitute of Developmental GeneticsIngolstädter Landstr. 1D-85764 NeuherbergGermany

Phone: +49-89/3187-2610
Fax: +49-89/3187-4620

Email:
graw[at]helmholtz-muenchen.de

Website:
www.helmholtz-muenchen.de/en/idg/group-molecular-eye-development/research-areas/index.html

Current Research Projects

  • Project 1
    Generation and characterization of new mouse mutants for eye disorders by ENU mutagenesis
  • Project 2
    Phenotypic characterization of mouse mutants for vision and eye defects (supported by the NGFN and EU)
  • Project 3
    Molecular characterization of families suffering from eye disorders (mainly cataracts)
  • Project 4
    Epidemiology of eye disorders

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