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Ocular Surface Research Group (OSG)

The OSG is composed by 12 full-time persons: 2 ophthalmologists (with PhD titles), 6 PhD (3 biologists, 2 biochemists, 1 immunologist, 1 optometrist), 3 technicians, and 1 administrative manager. There are several predoctoral students (9 at present), 2 clinical fellows, and 3 ophthalmology residents involved in research projects.

Our group maintains activities in the three fields that define the overall activity of our Institution:

Academic activities: several members are involved in teaching at Medical School, Optometry School, and in the continuing medical education program for Ophthalmology residents, physicians, and nurses. The vast majority of our teaching is in the PhD Program in Visual Sciences and the Clinical fellowship in Ocular Surface and Immunology.
Clinical activites. The two ophthalmologists and one optometrist coordinate the Ocular Immunology Clinical Unit and the Contactology Unit, respectively. Importantly, one of our ophthalmologist is uncharged of the Ocular Surface Reconstruction Unit, where clinical trials on cell therapy are starting at present
Research. The main activity of our OSG, divided into the following research lines:
1. Inflammation (allergy, dry eye, uveitis)
2. Ocular surface reconstruction by tissue engineering and cell therapy
3. Nanotherapy for ocular inflammation

Group Leader

Margarita Calonge
[more information]

Contact

University of Valladolid

IOBA (Institute of Applied Ophthalmobiology)
Campus Miguel Delibes
Camino del Cementerio s/n
47011 Valladolid
Spain

Phone: +34983184750
Fax: +34983184762

Email:
calonge[at]ioba.med.uva.es

Website:
www.ioba.med.uva.es

Methodology

Environmental Chamber for human studies under controlled environmental conditions
In vitro models of inflammation (especially with epithelial cells)
Analysis of human samples by molecular biology techniques, multianalyte system, and flow cytometry

Scientific Cooperations

Cooperation 1
Allergan Inc, USA
Cooperation 2
University College of London (Virginia Calder, PhD), UK
Cooperation 3
Dpt of Pharmaceutical Technology (Maria J. Alonso), University of Santiago de Compostela
Cooperation 4
Several groups on Biomaterials within the CIBER-BBN network
Cooperation 5
IBGM, University of Valladolid
Tissue Bank, San Francisco Foundation, Leon, Spain

Current Research Projects

Project 1:
CB06/01/0003.CIBER (Centre “Bioengineering, Biomaterials y Nanomedicine”. Instituto de Salud Carlos III, Ministry of Health, Spain
Project 2:
National Network on Cooperative Research in Health. Cell Therapy network. (TerCel), Ministry of Health, Spain
Project 3:
Regional Centre for Regenerative Medicine and Cell Therapy, Junta Castilla y León, Spain

Research Groups

People

Related Research Groups

anterior chamber: Reinhard, Thomas
anterior segment: Findl, Oliver; Hafezi, Farhad; Naumann, Gottfried; van Heyningen, Veronica
antibiotics/antifungals/antiparasitics
autoimmune disease: Greenwood, John; Hauck, Stefanie; Joachim, Stephanie; Sørensen, Torben Lykke; Ueffing, Marius; Xu, Heping
candidate gene analysis: Audo, Isabelle; Berger, Wolfgang; Bhattacharya, Shomi; Dollfus, Hélène; Inglehearn, Chris; Pastor, Jose-Carlos; Schaeffel, Frank; Wissinger, Bernd; Zeitz, Christina
cell adhesions/cell junctions: Greenwood, John; Wijnholds, Jan
cell survival: Ader, Marius; Andrés-Guerrero, Vanessa; Bovolenta, Paola; Cottet, Sandra; De la Rosa, Enrique; Griciuc, Ana; Grimm, Christian; Humphries, Peter; Martin, Keith; Miranda Sanz, María; Paquet-Durand, Francois; Picaud, Serge; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Thanos, Solon
chorioretinitis: Arden, Geoffrey
clinical (human) or epidemiologic studies: outcomes/complications: Berendschot, Tos; Butterworth, Jacqueline; Larsen, Michael; Research Group of Tunde Peto; Prokofyeva, Elena; Reinhard, Thomas; Jansonius, Nomdo; Rubin, Gary; Schmetterer, Leopold
clinical (human) or epidemiologic studies: prevalence/incidence: Berendschot, Tos; Butterworth, Jacqueline; Larsen, Michael; Research Group of Tunde Peto; Prokofyeva, Elena; Reinhard, Thomas; Jansonius, Nomdo; Rubin, Gary; Scanlon, Peter; Tassignon, Marie-José; Topouzis, Fotis; Zrenner, Eberhart
clinical (human) or epidemiologic studies: risk factor assessment: Bandello, Francesco; Berendschot, Tos; Guggenheim, Jez; Hammond, Chris; Larsen, Michael; Moore, Tony; Pastor, Jose-Carlos; Prokofyeva, Elena; Reinhard, Thomas; Detorakis, Efstathios; Jansonius, Nomdo; Scanlon, Peter; Schmetterer, Leopold; Topouzis, Fotis
clinical (human) or epidemiologic studies: systems/equipment/techniques: Bach, Michael; Berendschot, Tos; Cordeiro, M Francesca; Larsen, Michael; Németh, János; Research Group of Tunde Peto; Jansonius, Nomdo; Schmetterer, Leopold; Topouzis, Fotis; Wilhelm, Barbara
clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials: Arden, Geoffrey; Auricchio, Alberto; Berendschot, Tos; Cordeiro, M Francesca; Holz, Frank G.; Jager, Martine; Larsen, Michael; Navea, Amparo; Németh, János; Research Group of Tunde Peto; Prokofyeva, Elena; Reinhard, Thomas; Detorakis, Efstathios; Tsilimbaris, Miltiadis; Scanlon, Peter; Schmetterer, Leopold; Skorkovská, Karolína; Tepelus, Tudor-Cosmin; Topouzis, Fotis; Zrenner, Eberhart
clinical laboratory testing: Bach, Michael; Berendschot, Tos; Cordeiro, M Francesca; Coupland, Sarah; Findl, Oliver
clinical research methodology: Bach, Michael; Barbur, John; Beattie, Renwick; Berendschot, Tos; Hoffmann, Michael; Reinhard, Thomas; Zrenner, Eberhart
conjunctiva: Andrés-Guerrero, Vanessa; Coupland, Sarah; Németh, János; Paulsen, Friedrich; Reinhard, Thomas
conjunctivitis
contact lens
cornea: clinical science: Hafezi, Farhad; Lombardo, Marco; Naumann, Gottfried; Németh, János; Reinhard, Thomas; Kymionis, George
cornea: basic science: Graw, Jochen; Hafezi, Farhad; Johnsen-Soriano, Siv; Lombardo, Marco; Meek, Keith; Paulsen, Friedrich; Reinhard, Thomas
cornea: endothelium: Butterworth, Jacqueline; Reinhard, Thomas; Kymionis, George
cornea: epithelium: Butterworth, Jacqueline; Lombardo, Marco; Németh, János; Paulsen, Friedrich; Reinhard, Thomas; Kymionis, George; Tassignon, Marie-José
cornea: storage: Lombardo, Marco; Reinhard, Thomas
cornea: stroma and keratocytes: Butterworth, Jacqueline; Hafezi, Farhad; Lombardo, Marco; Meek, Keith; Reinhard, Thomas; Kymionis, George
cornea: surface mucins: Paulsen, Friedrich
cornea: tears/tear film/dry eye: Andrés-Guerrero, Vanessa; Grus, Franz; Hammond, Chris; Németh, János; Paulsen, Friedrich; Reinhard, Thomas; Tassignon, Marie-José
corticosteroids: Pastor, Jose-Carlos
cyclosporine: Reinhard, Thomas
cytokines/chemokines: Arden, Geoffrey; Grimm, Christian; Reinhard, Thomas
cytology: Reinhard, Thomas
cytomegalovirus
flow cytometry: Reinhard, Thomas; Tsilimbaris, Miltiadis; Xu, Heping
gene transfer/gene therapy: Auricchio, Alberto; Bhattacharya, Shomi; Biel, Martin; Bujakowska, Kinga; Chadderton, Naomi; Goureau, Olivier; Hamel, Christian ✝; Lorenz, Birgit; Lotery, Andrew John; MacLaren, Robert; Martin, Keith; Palfi, Arpad; Roska, Botond; Seeliger, Mathias; Stieger, Knut; Wijnholds, Jan; Wolfrum, Uwe
genetics: Audo, Isabelle; Banfi, Sandro; Baraas, Rigmor; Bergen, Arthur; Berger, Wolfgang; Bhattacharya, Shomi; Bujakowska, Kinga; Butterworth, Jacqueline; Coupland, Sarah; Cremers, Frans; den Hollander, Anneke; Grau, Tanja; Graw, Jochen; Guggenheim, Jez; Hamel, Christian ✝; Hammond, Chris; Holz, Frank G.; Inglehearn, Chris; Jager, Martine; Kennedy, Breandan; Lagreze, Wolf; Lotery, Andrew John; MacLaren, Robert; Moore, Tony; Neuhauss, Stephan; O'Driscoll, Ciara; Papageorgiou, Eleni; Petersen, Michael; Tsilimbaris, Miltiadis; Rivolta, Carlo; Roepman, Ronald; Schimpf-Linzenbold, Simone; Topouzis, Fotis; Zeitz, Christina
herpes simplex virus: Naumann, Gottfried; Reinhard, Thomas
immune tolerance/privilege: Jager, Martine; Reinhard, Thomas
immunohistochemistry: Ader, Marius; Berger, Wolfgang; Biel, Martin; Bovolenta, Paola; Coupland, Sarah; Dedek, Karin; Dedek, Karin; Ekström, Per; Goureau, Olivier; Griciuc, Ana; Grus, Franz; Heiduschka, Peter; Jager, Martine; Joachim, Stephanie; Julien, Sylvie; Kennedy, Breandan; Limb, Astrid; Lütjen-Drecoll, Elke; Marigo, Valeria; Neuhauss, Stephan; O'Driscoll, Ciara; Palfi, Arpad; Reinhard, Thomas; Sennlaub, Florian; Roepman, Ronald; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Strettoi, Enrica; van Veen, Theo; Vitanova, Liliya; Wässle, Heinz; Wolfrum, Uwe
immunomodulation/immunoregulation: Jager, Martine; Joachim, Stephanie; Reinhard, Thomas; Sørensen, Torben Lykke; Tassignon, Marie-José; Xu, Heping
inflammation: Greenwood, John; Lengyel, Imre; Lotery, Andrew John; Miranda Sanz, María; Reinhard, Thomas; Stitt, Alan; Sennlaub, Florian; Romero, Francisco Javier; Sørensen, Torben Lykke; Xu, Heping
keratitis
keratoconus: Hafezi, Farhad; Inglehearn, Chris; Reinhard, Thomas; Tejedor-Fraile, Jaime
keratoprostheses
lacrimal gland: Paulsen, Friedrich
microscopy: light/fluorescence/immunohistochemistry: Ader, Marius; Berger, Wolfgang; Bovolenta, Paola; Dedek, Karin; Dedek, Karin; Goureau, Olivier; Jager, Martine; Julien, Sylvie; Kennedy, Breandan; Limb, Astrid; Marigo, Valeria; Palfi, Arpad; Sennlaub, Florian; Vitanova, Liliya; Wässle, Heinz; Wolfrum, Uwe
pterygium: Detorakis, Efstathios
retina: Ader, Marius; AIBILI; Andrés-Guerrero, Vanessa; Arango-Gonzalez, Blanca; Arden, Geoffrey; Audo, Isabelle; Auricchio, Alberto; Bach, Michael; Bair, Wyeth; Bandello, Francesco; Banfi, Sandro; Baraas, Rigmor; Bergen, Arthur; Berger, Wolfgang; Bethge, Matthias; Bhattacharya, Shomi; Biel, Martin; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Cangiano, Lorenzo; Chadderton, Naomi; Chakravarthy, Usha; Cordeiro, M Francesca; Cotter, Tom G.; Cottet, Sandra; Cremers, Frans; Dedek, Karin; Dedek, Karin; den Hollander, Anneke; Ekström, Per; Enzmann, Volker; Euler, Thomas; Findl, Oliver; Goureau, Olivier; Grau, Tanja; Graw, Jochen; Greenwood, John; Grimm, Christian; Grus, Franz; Guenther, Elke; Hamel, Christian ✝; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Hindges, Robert; Holz, Frank G.; Humphries, Peter; Inglehearn, Chris; Joachim, Stephanie; Johnsen-Soriano, Siv; Julien, Sylvie; Kamermans, Maarten; Karl, Mike O.; Kawasaki, Aki; Kennedy, Breandan; Krishnakumar, Arjun; Lagreze, Wolf; Langmann, Thomas; Larsen, Michael; Lengyel, Imre; Limb, Astrid; Liu, Quing; Lorenz, Birgit; Lotery, Andrew John; MacLaren, Robert; Marigo, Valeria; Martin, Keith; Miranda Sanz, María; Moore, Tony; Naumann, Gottfried; Navea, Amparo; O'Driscoll, Ciara; Palfi, Arpad; Paquet-Durand, Francois; Pastor, Jose-Carlos; Petersen, Michael; Picaud, Serge; Pro Retina Deutschland; Reichenbach, Andreas; Reim, Martin; Stitt, Alan; Sennlaub, Florian; Tsilimbaris, Miltiadis; Jansonius, Nomdo; Vignali, Roberto; Retina Suisse; Riva, Charles; Rivolta, Carlo; Roepman, Ronald; Romero, Francisco Javier; Roska, Botond; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Scanlon, Peter; Schaeffel, Frank; Schimpf-Linzenbold, Simone; Seeliger, Mathias; Stieger, Knut; Strauss, Olaf; Strettoi, Enrica; Sørensen, Torben Lykke; Tejedor-Fraile, Jaime; Thanos, Solon; Ueffing, Marius; van Heyningen, Veronica; van Veen, Theo; Veruki, Margaret; Vitanova, Liliya; Wässle, Heinz; Weber, Bernhard; Wijnholds, Jan; Wissinger, Bernd; Wolfrum, Uwe; Wright, Alan; Xu, Heping; Zeitz, Christina; Zrenner, Eberhart
sclera: Beattie, Renwick; Liu, Quing; Meek, Keith
trachoma
transplantation: Ader, Marius; Limb, Astrid; MacLaren, Robert; Kymionis, George; Wijnholds, Jan
uvea: Coupland, Sarah
uveitis-clinical/animal model: Dias, Aylvin; Greenwood, John; Hauck, Stefanie; Ueffing, Marius; Xu, Heping
varicella zoster virus
vascular endothelial growth factor: Bandello, Francesco; Berendschot, Tos; Jager, Martine; Lorenz, Birgit; Stitt, Alan
dry eye: Andrés-Guerrero, Vanessa; Grus, Franz; Hammond, Chris; Németh, János; Paulsen, Friedrich; Reinhard, Thomas; Schmetterer, Leopold; Tassignon, Marie-José
ocular allergy
ocular drug delivery
nanomedicine
stem cell therapy