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Retinal information processing: Pharmacology and pathologies

Retinal information processing is investigated on cultured or dissociated cells as well as on retinal slices or ex vivo retina at the single cell level with the patch clamp technique or at a network scale with the multielectrode array recording technique.

Cultures of purified neurones or retinal explants are also used to develop neuroprotective strategies that are subsequently validated on animal models characterized on a morphofunctional platform (in vivo imaging, electroretinogram, behaviour).

Methodology

  • Cell culture: purified retinal cells to retinal explants
  • Electrophysiology: In vitro single cells (patch clamp), multielectrode array recording on ex vivo retina, in vivo electroretinogram
  • In vivo analysis of animal models: imaging techniques, behaviour, electrophysiology, intraocular pressure

Scientific Cooperations

  • Cooperation 1
    Botond Roska, FMI, Basel, Switzerland
  • Cooperation 2
    Don Zack, John Hopkins Hospital, USA
  • Cooperation 3
    Cheryl Craft, University of Southern California, USA
  • Cooperation 4
    Philippe Bergonzo, CEA, Saclay, France
  • Cooperation 5
    Lionel Rousseau, ESIEE, Noisy le grand, France

Group Leader

Serge A. Picaud
[more information]

Contact

Institut De La Vision

17 rue Moreau
75 012 Paris
France

Phone: (33) 1 53 46 25 92
Fax: (33) 1 53 46 25 02

Email
serge.picaud[at]inserm.fr

Website
www.institut-vision.org

Current Research Projects

  • Project 1
    GABA function in retinal information processing
  • Project 2
    Retinal toxicity of the anti-epileptic drug, vigabatrin
  • Project 3
    Retinal prostheses to restore vision in blind patients
  • Project 4
    Neuroprotection of retinal ganglion cells in glaucoma

Research Groups

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