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Institute of Human Genetics

The focus of the research group of Bernhard Weber is on disease mechanisms in hereditary as well as multifactorial retinal degenerations

Methodology

Generation of mouse models – transgene, knock-in, knock-out
Genetic, biochemistry, cell biology, functional assays

Scientific Cooperations

Cooperation 1
Robert, S. Molday, Department of Biochemistry and Molecular Bioloqv, University of British Columbia, Vancouver, B.C., Canada
Cooperation 2
William W. Hauswirth, Ophthalmology, University of Florida, Gainesville, FL
Cooperation 3
Rando Allikmets, Departments of Ophthalmology and Pathology & Cell Biology, Columbia University, New York, NY
Cooperation 4
Sheila A. Fisher, Department of Medical and Molecular Genetics, Guy's King's and St Thomas' School of Medicine, King's College London, London, United Kingdom
Cooperation 5
Ulrich Kellner, EyeCentre Siegburg, Siegburg-Bonn, Germany

Group Leader

Bernhard Weber
[more information]

Contact

University of Regensburg

Franz-Josef-Strauss-Allee 11
D-93053 Regensburg
Germany

Phone: +49-941 944 5400
Fax: +49-941 944 5402

Email:
bweb[at]klinik.uni-regensburg.de

Website:
www-huge.uni-regensburg.de/Humangenetik.shtml

Current Research Projects

Project 1
Function of bestrophin-1 and molecular pathology of Best disease mutations
Project 2
The role of retinoschisin - Identification of interacting partners
Project 3
Therapeutic approaches in hereditary retinal degeneration – the retinoschisin-deficient mouse as a model
Project 4
Genetics of age-related macular degeneration – Understanding disease pathology

Research Groups

People

Related Research Groups

age-related macular degeneration: Ader, Marius; AIBILI; Arden, Geoffrey; Audo, Isabelle; Beattie, Renwick; Berendschot, Tos; Bergen, Arthur; Berger, Wolfgang; Bird, Alan; Cremers, Frans; den Hollander, Anneke; Dias, Aylvin; Enzmann, Volker; Fighting Blindness; Greenwood, John; Grimm, Christian; Grus, Franz; Hammond, Chris; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Holz, Frank G.; Humphries, Peter; Inglehearn, Chris; Joachim, Stephanie; Johnsen-Soriano, Siv; Julien, Sylvie; Kennedy, Breandan; Larsen, Michael; Lengyel, Imre; Lotery, Andrew John; Moore, Tony; Navea, Amparo; Pastor, Jose-Carlos; Petersen, Michael; Research Group of Tunde Peto; Sennlaub, Florian; Tsilimbaris, Miltiadis; Riva, Charles; Rubin, Gary; Schmetterer, Leopold; Strauss, Olaf; Sørensen, Torben Lykke; Topouzis, Fotis; Ueffing, Marius; Wright, Alan; Xu, Heping
cell membrane/membrane specializations
degenerations/dystrophies: Audo, Isabelle; Banfi, Sandro; Berendschot, Tos; Bhattacharya, Shomi; Biel, Martin; Cordeiro, M Francesca; De la Rosa, Enrique; Ekström, Per; Grau, Tanja; Grimm, Christian; Guenther, Elke; Hicks, David; Johnsen-Soriano, Siv; Kennedy, Breandan; Kustermann, Stefan; Larsen, Michael; Marigo, Valeria; Strettoi, Enrica
inner retina dysfunction: biochemistry and cell biology: Cotter, Tom G.; Kennedy, Breandan; Strettoi, Enrica; Wolfrum, Uwe; Zeitz, Christina
macular dystrophy, inherited: Audo, Isabelle; Auricchio, Alberto; Bandello, Francesco; Berger, Wolfgang; Cottet, Sandra; Holz, Frank G.; Langmann, Thomas; Larsen, Michael; Lotery, Andrew John; Moore, Tony; Navea, Amparo; Petersen, Michael; Tsilimbaris, Miltiadis
molecular diagnostics: Bergen, Arthur; Berger, Wolfgang; Grau, Tanja; Holz, Frank G.; Petersen, Michael; van Heyningen, Veronica
proteins encoded by disease genes: Berger, Wolfgang; Grau, Tanja; Roepman, Ronald; Wijnholds, Jan; Wolfrum, Uwe
retinal degenerations: cell biology: Arango-Gonzalez, Blanca; Arden, Geoffrey; Audo, Isabelle; Bhattacharya, Shomi; Biel, Martin; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Cordeiro, M Francesca; Ekström, Per; Enzmann, Volker; Greenwood, John; Grimm, Christian; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Johnsen-Soriano, Siv; Karl, Mike O.; Kennedy, Breandan; Kustermann, Stefan; Langmann, Thomas; Lengyel, Imre; Marigo, Valeria; Martin, Keith; Palfi, Arpad; Paquet-Durand, Francois; Picaud, Serge; Reichenbach, Andreas; Stitt, Alan; Sennlaub, Florian; Tsilimbaris, Miltiadis; Roepman, Ronald; Sancho-Pelluz, Javier; Seeliger, Mathias; Stieger, Knut; Strauss, Olaf; Strettoi, Enrica; Sørensen, Torben Lykke; Thanos, Solon; Ueffing, Marius; Wijnholds, Jan; Wolfrum, Uwe
retinal degenerations: hereditary: Arden, Geoffrey; Audo, Isabelle; Auricchio, Alberto; Bach, Michael; Banfi, Sandro; Baraas, Rigmor; Bergen, Arthur; Bhattacharya, Shomi; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Chadderton, Naomi; Cottet, Sandra; Cremers, Frans; den Hollander, Anneke; Ekström, Per; Graw, Jochen; Hamel, Christian ✝; Inglehearn, Chris; Kennedy, Breandan; Langmann, Thomas; Lorenz, Birgit; Lotery, Andrew John; MacLaren, Robert; O'Driscoll, Ciara; Palfi, Arpad; Paquet-Durand, Francois; Petersen, Michael; Tsilimbaris, Miltiadis; Rivolta, Carlo; Roepman, Ronald; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Schimpf-Linzenbold, Simone; Seeliger, Mathias; Stieger, Knut; Strauss, Olaf; van Veen, Theo; Wijnholds, Jan; Wissinger, Bernd; Wright, Alan; Zrenner, Eberhart
retinal pigment epithelium: Arden, Geoffrey; Bergen, Arthur; Bhattacharya, Shomi; Bird, Alan; Bovolenta, Paola; Greenwood, John; Hamel, Christian ✝; Heiduschka, Peter; Hicks, David; Holz, Frank G.; Julien, Sylvie; Lengyel, Imre; MacLaren, Robert; Marigo, Valeria; Pastor, Jose-Carlos; Sennlaub, Florian; Tsilimbaris, Miltiadis; Strauss, Olaf; Thanos, Solon; Ueffing, Marius
transcription factors: Banfi, Sandro; Bovolenta, Paola; Goureau, Olivier; Grimm, Christian; Hicks, David; Kennedy, Breandan; Langmann, Thomas; Paquet-Durand, Francois; Vignali, Roberto
transgenics/knock-outs: Bovolenta, Paola; Bujakowska, Kinga; Hindges, Robert; Humphries, Peter; Kennedy, Breandan; Langmann, Thomas; Lucas, Robert; Roepman, Ronald; Wijnholds, Jan; Wissinger, Bernd
hereditary retinal dystrophy
case /control association studies
genetic mouse model: Biel, Martin
functional studies

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