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John Greenwood

Short CV

1977 BSc (Hons), Physiology and Biochemistry, University of Reading.
1983 PhD, Department of Neuropathology, Institute of Psychiatry, Faculty of Medicine, University of London.
1993 MRCPath.
2001 FRCPath
2008-present Head of the Research Department of Cell Biology, Institute of Ophthalmology.

Documents

CV of John Greenwood [pdf]

Scientifc Interest

My main scientific interests are retinal/brain vascular biology and RPE cell biology. The role of the blood-retina barrier plays in recruiting immune cells, the factors controlling vascular pathology, and the role of RPE cells in retinal degeneration constitute the principle focus of my research activity.

Memberships

  • Association for Research in Vision and Ophthalmology (ARVO)
John Greenwood
John Greenwood

Research Group

Department of Cell Biology
[more information]

Contact

UCL Institute of Ophthalmology

11-43 Bath Street
London SE5 8BN
United Kingdom

Phone: +44 (0)2076086858

Email:
j.greenwood[at]ucl.ac.uk

Key Publications

  1. Turowski, P., Martinelli, R., Crawford, R., Wateridge, D., Papagiorgiou, A-P., Lampugnani, M.G., Gamp, A., Vestweber, D., Adamson, P., Dejana, E. and Greenwood, J. (2008).
    Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration.
    J. Cell Sci. 121:29-37.
  2. Coffey, P.J., Gias, C., McDermott, C.J., Lundh, P., Pickering, M.C., Sethi, C., Bird, A.,. Fitzke, F.W., Maass, A., Holder, G.E., Luthert, P.J., Salt, T.E., Moss, S.E. and Greenwood, J. (2007).
    Complement factor H-deficiency in aged mice causes retinal abnormalities and visual dysfunction.
    Proc. Natl. Acad. Sci. USA 104:16651-16656.
  3. Greenwood, J. and Mason, J.C. (2007).
    Statins and the vascular endothelial inflammatory response.
    Trends Immunol. 28: 88-98.
  4. Greenwood, J., Steinman, L. and Zamvil, S.S. (2006).
    Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
    Nat. Rev. Immunol. 6: 358-370.
  5. Gegg, M., Harry, R., Hankey, D., Zambarakji, H., Pryce, G., Baker, D., Adamson, P., Calder, V. and Greenwood, J. (2005).
    Suppression of autoimmune retinal disease by lovastatin does not require TH2 cytokine induction.
    J. Immunol. 174:2327-2335.
  6. Turowski, P., Adamson, P., Sathia, J., Zhang, J.J., Moss, S.E., Aylward, G.W., Hayes, M.J,, Kanuga, N. and Greenwood, J. (2004).
    Basement membrane-dependent modification of phenotype and gene expression in the human retinal pigment epithelial cell line ARPE-19.
    Invest. Ophthalmol. Vis. Sci . 45:2786-2794.
  7. Greenwood, J., Amos, C.L., Walters, C.E., Couraud, P-O., Lyck, R., Engelhardt, B. and Adamson, P. (2003).
    Intracellular domain of brain endothelial ICAM-1 is essential for T-lymphocyte-mediated signalling and migration.
    J. Immunol. 171:2099-2108.
  8. Greenwood, J., Walters, C.E., Pryce, G., Kanuga, N., Beraud, E., Baker, D., and Adamson, P. (March 5, 2003).
    Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.
    FASEB J. On line. 10.1096/fj.02-1014fje.
  9. Coffey, P.J., Girman, S., Wang, S.M., Hetherington, L., Keegan, D.J., Adamson, P., Greenwood, J. and Lund, R.D. (2002).
    Long-term preservation of cortically dependent visual function in dystrophic RCS rats by transplantation of immortalized retinal pigment epithelial cells.
    Nat. Neurosci. 5:53-56.
  10. Lund, R.D., Adamson, P. Sauvé, Y., Girman, S.V., Keegan, D., Winton, H., Kwan, A., Beauchene, L., Zerbib, A., Hetherington, L., Couraud, P.O., Coffey, P. and Greenwood, J. (2001).
    Subretinal transplantation of a genetically engineered human RPE cell line prevents visual loss in the RCS rat.
    Proc. Natl. Acad. Sci. USA 98:9942-9947.

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