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Arpad Palfi

Current Research Projects

  • Suppression and replacement strategies towards development of gene therapeutic approaches for retinal degenerations
  • Role and mechanism of action of microRNAs in the normal and degenerating retina

Methodology

Histology, immunohystochemistry, PAGE/Western-blot, in situ hybridization, qRT-PCR, microarray, cloning, cell culture, FACS, RNAi, microRNA, gene transfer, subretinal injection, AAV

Selected Publications

  1. Loscher CJ, Hokamp K, Wilson JH, Li T, Humphries P, Farrar GJ, Palfi A.
    A common microRNA signature in mouse models of retinal degeneration.
    Exp Eye Res. 2008 Dec;87(6):529-34. Epub 2008 Sep 13. PMID: 1883487
  2. Carol Loscher, Karsten Hokamp, Paul F. Kenna, Alasdair C. Ivens, Peter Humphries, Arpad Palfi and G. Jane Farrar.
    Altered retinal microRNA expression profile in mouse model of retinitis pigmentosa.
    Genome Biol. 2007 Nov 22;8(11):R248 PMID: 18034880
  3. O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ.
    RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
    Am J Hum Genet. 2007 Jul;81(1):127-35. Epub 2007 May 23. PMID: 17564969
  4. Kennan A, Aherne A, Palfi A, Humphries M, McKee A, Stitt A, Simpson DA, Demtroder K, Orntoft T, Ayuso C, Kenna PF, Farrar GJ, Humphries P.
    Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.
    Hum Mol Genet 2002 Mar 1; 11(5):547-57, PMID: 11875049
  5. Millington-Ward S, Oneill B, Tuohy G, Al-Jandal N, Kiang AS, Kenna PF, Palfi A, Hayden P, Mansergh F, Kennan A, Humphries P, Farrar GJ.
    Strategems in vitro for gene therapies directed to dominant mutations.
    Hum Mol Genet 1997, 9:1415-1426, PMID: 9285777
Arpad Palfi
Arpad Palfi

Research Group

Ocular Genetic Unit

Contact

Trinity College Dublin

Department of Genetics,
Ocular Genetic Unit

Dublin 2
Ireland

Phone: +353-1-8962484
Fax: +353-1-8963848

palfia[at]tcd.ie

www.tcd.ie/Genetics

Documents

CV of Arpad Palfi [pdf]

Research Groups

People

Related Research Groups

gene/expression
Banfi, Sandro
Bergen, Arthur
Bovolenta, Paola
Bujakowska, Kinga
Butterworth, Jacqueline
Chadderton, Naomi
Chakravarthy, Usha
Coupland, Sarah
Dollfus, Hélène
Goureau, Olivier
Grau, Tanja
Graw, Jochen
Grimm, Christian
Guggenheim, Jez
Hamel, Christian ✝
Humphries, Peter
Kennedy, Breandan
Krishnakumar, Arjun
Lengyel, Imre
O'Driscoll, Ciara
Rivolta, Carlo
Roska, Botond
Schaeffel, Frank
Tassignon, Marie-José
Topouzis, Fotis
van Heyningen, Veronica
Zeitz, Christina
gene microarray
Ader, Marius
Bergen, Arthur
Chakravarthy, Usha
Coupland, Sarah
Cremers, Frans
Dollfus, Hélène
Hamel, Christian ✝
Hindges, Robert
Jager, Martine
Kennedy, Breandan
Petersen, Michael
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Schaeffel, Frank
gene transfer/gene therapy
Auricchio, Alberto
Bhattacharya, Shomi
Biel, Martin
Bujakowska, Kinga
Calonge, Margarita
Chadderton, Naomi
Goureau, Olivier
Hamel, Christian ✝
Kustermann, Stefan
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
Martin, Keith
Roska, Botond
Seeliger, Mathias
Stieger, Knut
Wijnholds, Jan
Wolfrum, Uwe
microscopy: light/fluorescence/immunohistochemistry
Ader, Marius
Berger, Wolfgang
Bovolenta, Paola
Calonge, Margarita
Dedek, Karin
Dedek, Karin
Goureau, Olivier
Jager, Martine
Julien, Sylvie
Kennedy, Breandan
Kustermann, Stefan
Limb, Astrid
Marigo, Valeria
Sennlaub, Florian
Vitanova, Liliya
Wässle, Heinz
Wolfrum, Uwe
photoreceptors
Ader, Marius
Arango-Gonzalez, Blanca
Arden, Geoffrey
Artal, Pablo
Auricchio, Alberto
Baraas, Rigmor
Berendschot, Tos
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Bujakowska, Kinga
Cangiano, Lorenzo
Chadderton, Naomi
Cottet, Sandra
Dell'Orco, Daniele
Ekström, Per
Goureau, Olivier
Heiduschka, Peter
Hicks, David
Julien, Sylvie
Kamermans, Maarten
Kawasaki, Aki
Kennedy, Breandan
Kremers, Jan
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Marigo, Valeria
O'Driscoll, Ciara
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Strettoi, Enrica
Ueffing, Marius
van Veen, Theo
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Zeitz, Christina
retina
Ader, Marius
AIBILI
Andrés-Guerrero, Vanessa
Arango-Gonzalez, Blanca
Arden, Geoffrey
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Bair, Wyeth
Bandello, Francesco
Banfi, Sandro
Baraas, Rigmor
Bergen, Arthur
Berger, Wolfgang
Bethge, Matthias
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Calonge, Margarita
Cangiano, Lorenzo
Chadderton, Naomi
Chakravarthy, Usha
Cordeiro, M Francesca
Cotter, Tom G.
Cottet, Sandra
Cremers, Frans
Dedek, Karin
Dedek, Karin
den Hollander, Anneke
Ekström, Per
Enzmann, Volker
Euler, Thomas
Findl, Oliver
Goureau, Olivier
Grau, Tanja
Graw, Jochen
Greenwood, John
Grimm, Christian
Grus, Franz
Guenther, Elke
Hamel, Christian ✝
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Hindges, Robert
Holz, Frank G.
Humphries, Peter
Inglehearn, Chris
Joachim, Stephanie
Johnsen-Soriano, Siv
Julien, Sylvie
Kamermans, Maarten
Karl, Mike O.
Kawasaki, Aki
Kennedy, Breandan
Krishnakumar, Arjun
Kustermann, Stefan
Lagreze, Wolf
Langmann, Thomas
Larsen, Michael
Lengyel, Imre
Limb, Astrid
Liu, Quing
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
Marigo, Valeria
Martin, Keith
Miranda Sanz, María
Moore, Tony
Naumann, Gottfried
Navea, Amparo
O'Driscoll, Ciara
Paquet-Durand, Francois
Pastor, Jose-Carlos
Petersen, Michael
Picaud, Serge
Pro Retina Deutschland
Reichenbach, Andreas
Reim, Martin
Stitt, Alan
Sennlaub, Florian
Tsilimbaris, Miltiadis
Jansonius, Nomdo
Vignali, Roberto
Retina Suisse
Riva, Charles
Rivolta, Carlo
Roepman, Ronald
Romero, Francisco Javier
Roska, Botond
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Scanlon, Peter
Schaeffel, Frank
Schimpf-Linzenbold, Simone
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
Strettoi, Enrica
Sørensen, Torben Lykke
Tejedor-Fraile, Jaime
Thanos, Solon
Ueffing, Marius
van Heyningen, Veronica
van Veen, Theo
Veruki, Margaret
Vitanova, Liliya
Wässle, Heinz
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Wright, Alan
Xu, Heping
Zeitz, Christina
Zrenner, Eberhart
retina: distal (photoreceptors, horizontal cells, bipolar cells)
Arden, Geoffrey
Baraas, Rigmor
Bujakowska, Kinga
Cangiano, Lorenzo
Dedek, Karin
Dedek, Karin
Kamermans, Maarten
Kawasaki, Aki
Larsen, Michael
Tsilimbaris, Miltiadis
Roska, Botond
Zeitz, Christina
retinal degenerations: cell biology
Arango-Gonzalez, Blanca
Arden, Geoffrey
Audo, Isabelle
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Cordeiro, M Francesca
Ekström, Per
Enzmann, Volker
Greenwood, John
Grimm, Christian
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Johnsen-Soriano, Siv
Karl, Mike O.
Kennedy, Breandan
Kustermann, Stefan
Langmann, Thomas
Lengyel, Imre
Marigo, Valeria
Martin, Keith
Paquet-Durand, Francois
Picaud, Serge
Reichenbach, Andreas
Stitt, Alan
Sennlaub, Florian
Tsilimbaris, Miltiadis
Roepman, Ronald
Sancho-Pelluz, Javier
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
Strettoi, Enrica
Sørensen, Torben Lykke
Thanos, Solon
Ueffing, Marius
Weber, Bernhard
Wijnholds, Jan
Wolfrum, Uwe
retinal degenerations: hereditary
Arden, Geoffrey
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Banfi, Sandro
Baraas, Rigmor
Bergen, Arthur
Bhattacharya, Shomi
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cottet, Sandra
Cremers, Frans
den Hollander, Anneke
Ekström, Per
Graw, Jochen
Hamel, Christian ✝
Inglehearn, Chris
Kennedy, Breandan
Langmann, Thomas
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
O'Driscoll, Ciara
Paquet-Durand, Francois
Petersen, Michael
Tsilimbaris, Miltiadis
Rivolta, Carlo
Roepman, Ronald
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Schimpf-Linzenbold, Simone
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
van Veen, Theo
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
Wright, Alan
Zrenner, Eberhart
retinitis pigmentosa
Ader, Marius
Arango-Gonzalez, Blanca
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Bergen, Arthur
Berger, Wolfgang
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cremers, Frans
De la Rosa, Enrique
den Hollander, Anneke
Dollfus, Hélène
Enzmann, Volker
Fighting Blindness
Griciuc, Ana
Hamel, Christian ✝
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Moore, Tony
Paquet-Durand, Francois
Tsilimbaris, Miltiadis
Rivolta, Carlo
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Seeliger, Mathias
van Veen, Theo
Wijnholds, Jan
Wolfrum, Uwe
Wright, Alan
Zrenner, Eberhart

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