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(James) Renwick Beattie

Current Research Projects

Developing the application of Raman spectroscopy in the non-invasive detection of early stage age related macular degeneration. Raman spectroscopy is a non-destructive, non-invasive laser based method, currently used to measure carotenoid levels in-vivo in the fovea. I am developing a modified Raman spectrometer capable of measuring advanced glycation and lipoxidation endproducts on the collagens of the Bruch’s membrane and sclera.

Methodology

  • Non-resonant Raman Spectroscopy
  • Principal Component Analysis/ Singular Value Decomposition
  • Partial-least Squares Regression
  • Discriminant Analysis
  • Developing novel noise-insensitive data processing methodologies

Selected Publications

  1. Beattie, J.R., Glenn, J.V., Boulton, M.E., Stitt, A.W., and McGarvey, J.J.
    Effect of signal intensity normalization on the multivariate analysis of spectral data in complex ‘real-world’ datasets.
    J. Raman Spectrosc. (2009) 40, p. 429-435.
  2. Pawlak, A.M., Glenn, J.V., Beattie, J.R., McGarvey, J.J., and Stitt, A.W
    Advanced glycation as a basis for understanding retinal aging and non-invasive risk prediction. Maillard Reaction: Recent Advances in Food and Biomedical Sciences.
    NYNAS (2008) 1126, p. 59-65
  3. Pawlak, A.M., Beattie, J.R., Glenn, J.V., Stitt, A.W., McGarvey, J.J.
    Raman spectroscopy of advanced glycation end products (AGEs), possible markers for progressive retinal dysfunction.
    J Raman Spec. (2008) 39, 1635-1642.
  4. Glenn J.V., Beattie J.R.*, Barrett L.J., Frizzell N., Thorpe S.R., Boulton M.E., McGarvey J.J., Stitt A.W.
    Confocal Raman microscopy can quantify advanced glycation endproduct (AGE) modifications in Bruch’s membrane leading to accurate, non-destructive prediction of ocular aging.
    FASEB J. (2007) 21, 3542-3552
  5. Beattie, J.R., Brockbank, S., McGarvey, J.J., Curry, W.J.
    Raman microscopy of porcine inner retinal layers from the area centralis.
    Mol Vis  (2007) 13, 1106-1113
  6. Beattie, J. R., Brockbank, S., McGarvey, J. J. & Curry, W. J.
    Effect of excitation wavelength on the Raman spectroscopy of the porcine photoreceptor layer from the area centralis.
    Molecular Vision (2005) 11, 825-832
Renwick Beattie
Renwick Beattie

Research Group

Centre for Vision and Vascular Science

Contact

Queen's University Belfast

School of Medicine, Dentistry & Biomedical Science
Royal Victoria Hospital

BT12 6BA Belfast
United Kingdom

Phone: 028-90635072

E-mail:
r.beattie[at]qub.ac.uk

Documents

CV of Renwick Beattie [pdf]

Research Groups

People

Related Research Groups

age-related macular degeneration
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aging
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Bruch's membrane
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clinical research methodology
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diabetes
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diabetic retinopathy
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imaging/image analysis: clinical
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imaging/image analysis: non-clinical
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pathology: human
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sclera
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