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Graham McGeown

Documents

CV of Graham McGeown [pdf]

Memberships

  • Association for Research in Vision and Ophthalmology (ARVO)
  • Physiological Society
  • American Physiological Society
  • British Microcirculation Society

    Scientifc Interest

    My interests focus on the role played by intracellular Ca2+ in the control of contractility in smooth muscle, particularly in retinal microvessels. This includes consideration of the effects of localised Ca2+-sparks, cell-wide Ca2+-waves and oscillations, and cell-to-cell spread of Ca2+-signals within microvessels.

    Much of this work is part of longstanding investigations into how diabetes, a major cause of blindness, affects these small blood vessels, and is carried out as part of an internationally recognised group of scientists studying the mechanisms responsible for diabetic retinopathy.

    Graham McGeown
    Graham McGeown

    Research Group

    Centre for Vision and Vascular Science

    [more information]

    Contact

    Queen's University Belfast

    Institute of Clinical Science A, Royal Victoria Hopsital
    Grosvenor Road
    BT12 6BA Belfast
    Northern Ireland

    Phone: +44 (0)28 90632629
    Fax: +44 (0)28 90632699

    Email:
    g.mcgeown[at]qub.ac.uk

    Website:
    www.qub.ac.uk/research-centres/CentreforVisionandVascularSciences/

    Key Publications

    1. Owen Jeffries, Mary McGahon, Peter Bankhead, Maria Manfredi Lozano, C Norman Scholfield, Tim M Curtis, and J Graham McGeown (in press)
      Ca-sparks, oscillations and SR Ca-stores are increased in retinal arteriolar myocytes via a cAMP/PKA dependent pathway following exposure to vasopressin.
      Invest. Ophthalmol. Vis. Sci.
    2. Mary McGahon, Maurice Needham, C. Norman Scholfield, J. Graham McGeown, and Tim M Curtis (2009)
      Ca2+-activated Cl- current in retinal arteriolar smooth muscle
      Invest. Ophthalmol. Vis. Sci. 50:364-371
    3. Toner E, Brennan GP, Wells K, McGeown JG, Fairweather I. (2008) Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica.
      Parasitology 135: 1189-1203
    4. Curtis TM, Tumelty J, Stewart MT, Arora AR, Lai FA, McGahon MK, Scholfield CN, McGeown JG. (2008).
      Modification of smooth muscle Ca(2+)-sparks by tetracaine: Evidence for sequential RyR activation.
      Cell Calcium 43: 142-54
    5. Curtis TM, Stitt AW, McGahon MK, Scholfield CN, McGeown JG. (2007).
      New developments in diabetic retinopathy.
      Expert Review of Ophthalmology 2: 947-956
    6. McGahon MK, Xiaohong Zhang, Scholfield CN, Curtis TM, McGeown. (2007).
      Selective downregulation of the BKb1 subunit in diabetic arteriolar myocytes.
      Channels 1: 141-143
    7. Scholfield CN, McGeown JG, Curtis TM. (2007)
      Cellular physiology of retinal and choroidal arteriolar smooth muscle cells.
      Microcirculation. 14:11-24.
    8. Curtis TM, Scholfield C, McGeown JG. (2007)
      Calcium signaling in ocular arterioles.
      Crit Rev Eukaryot Gene Expr. 17:1-12.
    9. McGahon MK, Dash DP, Arora A, Wall N, Dawicki J, Simpson DA, Scholfield CN, McGeown JG, Curtis TM. (2007)
      Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle.
      Circ Res. 100:703-11.
    10. McGahon MK, Dawicki JM, Arora A, Simpson DA, Gardiner TA, Stitt AW, Scholfield CN, McGeown JG, Curtis TM. (2007)
      Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.
      Am J Physiol Heart Circ Physiol. 292:H1001-8.
    11. Tumelty J, Scholfield N, Stewart M, Curtis T, McGeown G. (2007) Ca2+-sparks constitute elementary building blocks for global Ca2+-signals in myocytes of retinal arterioles.
      Cell Calcium 41:451-66.
    12. McGeown JG. (2006).
      Passing on the legacy: teaching capillary filtration and developing presentation skills using classic papers.
      Adv Physiol Educ. 30:108-12
    13. McGahon, M.K., Dawicki, J.M., Scholfield, C.N., McGeown, J.G., and Curtis, T.M. (2005).
      A-type potassium current in retinal arteriolar smooth muscle cells.
      Investigative Ophthalmology and Visual Science 46:3281-7
    14. Hughes, S.J., Wall, N., Scholfield, C.N., McGeown, J.G., Gardiner, T.A., Stitt, A.W., and Curtis, T.M. (2004).
      AGE-modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contractility in retinal microvascular pericytes.
      Molecular Vision 10:996-1004
    15. Curtis, T.M., Tumelty, J., Dawicki, J., Scholfield, C.N., and McGeown, J.G. (2004).
      Identification and spatiotemporal characterisation of spontaneous Ca2+ sparks and global Ca2+ oscillations in retinal arteriolar smooth muscle cells.
      Investigative Ophthalmology and Visual Science 45:4409-4414.
    16. Kumar, D., White, C., Fairweather, I.  and McGeown, J.G. (2004)  Electrophysiological and pharmacological characterization of K+-currents in muscle fibres isolated from the ventral sucker of Fasciola hepatica.
      Parasitology, 129, 779–793.
    17. McGeown, J.G. (2004)
      Interactions between inositol 1,4,5-trisphosphate receptors and ryanodine receptors in smooth muscle: one store or two? 
      Cell Calcium 35: 613-619

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