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Cell and Developmental Biology Unit

Members of the research group:

Prof. Robert Vignali
Prof. Massimiliano Andreazzoli
Prof. Giuseppina Barsacchi
Prof. Luciana Dente
Dr Federico Cremisi
Lei Lan, PhD
Martina Giannaccini, PhD student
Simone Macrì, Fellow
Sara Mariotti, Fellow

Methodology

Molecular embryology: misexpression and knockdown assays by microinjections/lipofection of mRNA and/or morpholino in developing Xenopus embryos; immunostaining and in situ hybridization
Cell culture and molecular biology techniques: transfection and gene expression analysis (cell transfection, RT-PCR, immunostaining and fluorescence analysis, confocal microscopy)

Scientific Cooperations

Cooperation 1:
Prof William Harris, Physiology Development and Neuroscience, University of Cambridge, U.K.
Cooperation 2:
Dr Jochen Wittbrodt, EMBL, Heidelberg
Cooperation 3:
Dr Simona Casarosa, Centre for Integrative Biology, Università di Trento, Italy
Cooperation 4:
Prof Rongqiao He, Chinese Academy of Sciences, Beijing
Cooperation 5:
Dr Vania Broccoli, DIBIT, HS Raffaele, Milan, Italy

Group Leader

Robert Vignali
[more information]

Contact

University of Pisa

Administration:
Dipartimento di Biologia
via Luca Ghini 5
56126 Pisa

Laboratoy:
Via G. Carducci 13
56010 GHEZZANO (PISA)
Italy

Phone: 0039-050-2211497
Fax: 0039-050-2211495

Email:
rvignali[at]biologia.unipi.it

Website:
www.unipi.it

Current Research Projects

Project 1:
How to drive embryonic stem cells toward a retinal fate: role of eye specific transcription factors
Project 2:
Molecular mechanisms of action of homeobox transcription factors in retinal development and cell commitment
Project 3:
Role of micro RNA in retinal cell commitment
Project 4:
Cell cycle dependent regulation of cell polarity and homeobox factors in the retina
Project 5:
Multipotency of retinal stem cells: role of RX1 transcription factor and its target genes

Research Groups

People

Related Research Groups

bipolar cells: Arden, Geoffrey; Baraas, Rigmor; Bujakowska, Kinga; Cangiano, Lorenzo; Dedek, Karin; Dedek, Karin; Euler, Thomas; Guenther, Elke; Kamermans, Maarten; Kawasaki, Aki; Larsen, Michael; Palfi, Arpad; Tsilimbaris, Miltiadis; Roska, Botond; Strettoi, Enrica; Veruki, Margaret; Wässle, Heinz; Zeitz, Christina
development: Ader, Marius; Arango-Gonzalez, Blanca; Artal, Pablo; Banfi, Sandro; Bovolenta, Paola; Dakin, Steven; De la Rosa, Enrique; Findl, Oliver; Goureau, Olivier; Graw, Jochen; Hindges, Robert; Hoffmann, Michael; Karl, Mike O.; Kennedy, Breandan; Lorenz, Birgit; Moore, Tony; Neuhauss, Stephan; Reichenbach, Andreas; Tsilimbaris, Miltiadis; Stoimenova, Bistra; Tassignon, Marie-José; Tejedor-Fraile, Jaime; Tepelus, Tudor-Cosmin; Thanos, Solon; van Heyningen, Veronica; Wissinger, Bernd
differentiation: Ader, Marius; Bovolenta, Paola; De la Rosa, Enrique; Goureau, Olivier; Marigo, Valeria
ganglion cells: Arden, Geoffrey; Bach, Michael; Bergen, Arthur; Bovolenta, Paola; Chadderton, Naomi; Cordeiro, M Francesca; De la Rosa, Enrique; Dedek, Karin; Dedek, Karin; Guenther, Elke; Hicks, David; Hindges, Robert; Joachim, Stephanie; Kremers, Jan; Lagreze, Wolf; Limb, Astrid; Lucas, Robert; Martin, Keith; Naumann, Gottfried; Picaud, Serge; Tsilimbaris, Miltiadis; Roska, Botond; Schimpf-Linzenbold, Simone; Strettoi, Enrica; Thanos, Solon; Vitanova, Liliya; Wissinger, Bernd
gene microarray: Ader, Marius; Bergen, Arthur; Chakravarthy, Usha; Coupland, Sarah; Cremers, Frans; Dollfus, Hélène; Hamel, Christian ✝; Hindges, Robert; Jager, Martine; Kennedy, Breandan; Palfi, Arpad; Petersen, Michael; Tsilimbaris, Miltiadis; Roska, Botond; Schaeffel, Frank
photoreceptors: Ader, Marius; Arango-Gonzalez, Blanca; Arden, Geoffrey; Artal, Pablo; Auricchio, Alberto; Baraas, Rigmor; Berendschot, Tos; Berger, Wolfgang; Biel, Martin; Bovolenta, Paola; Bujakowska, Kinga; Cangiano, Lorenzo; Chadderton, Naomi; Cottet, Sandra; Dell'Orco, Daniele; Ekström, Per; Goureau, Olivier; Heiduschka, Peter; Hicks, David; Julien, Sylvie; Kamermans, Maarten; Kawasaki, Aki; Kennedy, Breandan; Kremers, Jan; Langmann, Thomas; Larsen, Michael; MacLaren, Robert; Marigo, Valeria; O'Driscoll, Ciara; Palfi, Arpad; Paquet-Durand, Francois; Sennlaub, Florian; Tsilimbaris, Miltiadis; Roska, Botond; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Strettoi, Enrica; Ueffing, Marius; van Veen, Theo; Wijnholds, Jan; Wissinger, Bernd; Wolfrum, Uwe; Zeitz, Christina
proliferation: Bovolenta, Paola; Karl, Mike O.; Sennlaub, Florian
regeneration: Ader, Marius; Karl, Mike O.; Lagreze, Wolf; Stitt, Alan; Thanos, Solon
retina: Ader, Marius; AIBILI; Andrés-Guerrero, Vanessa; Arango-Gonzalez, Blanca; Arden, Geoffrey; Audo, Isabelle; Auricchio, Alberto; Bach, Michael; Bair, Wyeth; Bandello, Francesco; Banfi, Sandro; Baraas, Rigmor; Bergen, Arthur; Berger, Wolfgang; Bethge, Matthias; Bhattacharya, Shomi; Biel, Martin; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Calonge, Margarita; Cangiano, Lorenzo; Chadderton, Naomi; Chakravarthy, Usha; Cordeiro, M Francesca; Cotter, Tom G.; Cottet, Sandra; Cremers, Frans; Dedek, Karin; Dedek, Karin; den Hollander, Anneke; Ekström, Per; Enzmann, Volker; Euler, Thomas; Findl, Oliver; Goureau, Olivier; Grau, Tanja; Graw, Jochen; Greenwood, John; Grimm, Christian; Grus, Franz; Guenther, Elke; Hamel, Christian ✝; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Hindges, Robert; Holz, Frank G.; Humphries, Peter; Inglehearn, Chris; Joachim, Stephanie; Johnsen-Soriano, Siv; Julien, Sylvie; Kamermans, Maarten; Karl, Mike O.; Kawasaki, Aki; Kennedy, Breandan; Krishnakumar, Arjun; Lagreze, Wolf; Langmann, Thomas; Larsen, Michael; Lengyel, Imre; Limb, Astrid; Liu, Quing; Lorenz, Birgit; Lotery, Andrew John; MacLaren, Robert; Marigo, Valeria; Martin, Keith; Miranda Sanz, María; Moore, Tony; Naumann, Gottfried; Navea, Amparo; O'Driscoll, Ciara; Palfi, Arpad; Paquet-Durand, Francois; Pastor, Jose-Carlos; Petersen, Michael; Picaud, Serge; Pro Retina Deutschland; Reichenbach, Andreas; Reim, Martin; Stitt, Alan; Sennlaub, Florian; Tsilimbaris, Miltiadis; Jansonius, Nomdo; Retina Suisse; Riva, Charles; Rivolta, Carlo; Roepman, Ronald; Romero, Francisco Javier; Roska, Botond; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Scanlon, Peter; Schaeffel, Frank; Schimpf-Linzenbold, Simone; Seeliger, Mathias; Stieger, Knut; Strauss, Olaf; Strettoi, Enrica; Sørensen, Torben Lykke; Tejedor-Fraile, Jaime; Thanos, Solon; Ueffing, Marius; van Heyningen, Veronica; van Veen, Theo; Veruki, Margaret; Vitanova, Liliya; Wässle, Heinz; Weber, Bernhard; Wijnholds, Jan; Wissinger, Bernd; Wolfrum, Uwe; Wright, Alan; Xu, Heping; Zeitz, Christina; Zrenner, Eberhart
retinal development: Ader, Marius; Arango-Gonzalez, Blanca; Banfi, Sandro; Bovolenta, Paola; Goureau, Olivier; Hindges, Robert; Karl, Mike O.; Moore, Tony; Reichenbach, Andreas; Tsilimbaris, Miltiadis; Thanos, Solon; van Heyningen, Veronica
transcription factors: Banfi, Sandro; Bovolenta, Paola; Goureau, Olivier; Grimm, Christian; Hicks, David; Kennedy, Breandan; Langmann, Thomas; Paquet-Durand, Francois; Weber, Bernhard
cell fate
asymmetric cell division
homeobox
microRNA: Banfi, Sandro; Hindges, Robert
cell cycle

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