We are studying the role of ion channels in retinal function and diseases. To this end we use a variety of technologies including electrophysiology, imaging, immunohistochemistry as well genetic mouse models.
Our particular focus is on cyclic nucleotide-gated (CNG) and voltage-gated calcium channels.
We have generated a number of genetic mouse models to investigate the physiological roles of these proteins in vivo. Using these mouse models we are also studying the molecular basis of photoreceptor degeneration in cone dystrophies and retinitis pigmentosa.
Finally, we have established viral transfection systems (based on AAV and lentiviral vectors) to rescue retinal function in murine retina.
Butenandtstr. 5-1381377 MunichGermany