You are here: vision-research.eu » People » Research Groups » Germany » Biel, Martin

Center for Integrated Protein Science Munich - Pharmacology

We are studying the role of ion channels in retinal function and diseases. To this end we use a variety of technologies including electrophysiology, imaging, immunohistochemistry as well genetic mouse models.

Our particular focus is on cyclic nucleotide-gated (CNG) and voltage-gated calcium channels.

We have generated a number of genetic mouse models to investigate the physiological roles of these proteins in vivo. Using these mouse models we are also studying the molecular basis of photoreceptor degeneration in cone dystrophies and retinitis pigmentosa.

Finally, we have established viral transfection systems (based on AAV and lentiviral vectors) to rescue retinal function in murine retina.

Methodology

  • Mouse models
  • Electrophysiology – Calcium imaging
  • Immunohistochemistry
  • Viral gene transfer (AAV, lentiviral vectors)

Scientific Cooperations

Group Leader

Martin Biel
[more information]

Contact

Center for Integrated Protein Science Munich CIPSM and
Department of Pharmacy – Center for Drug Research

Butenandtstr. 5-1381377 MunichGermany

Phone: +49-89-2180-77327
Fax-Number: +49-89-2180-77326

Email:
mbiel[at]cup.uni-muenchen.de

Website:
www.cup.uni-muenchen.de/dept/ph/pharmakologie/biel.php

Current Research Projects

  • Project 1:
    Functional rescue of CNG channels  in genetic mouse models
  • Project 2:
    Analysis of signaling pathways linked to rod and cone photoreceptor degeneration
  • Project 3:
    Identification of molecular mechanisms of CNG channel targeting in photoreceptors
  • Project 4:
    Functional analysis of Cav1.4 in retinal circuits
  • Project 5:
    Orphan ion channels in retina

Research Groups

People

Related Research Groups

degenerations/dystrophies
Oops, an error occurred! Code: 202104200048190f82d542
electroretinography: non-clinical
Oops, an error occurred! Code: 20210420004819fa11b6ff
gene transfer/gene therapy
Oops, an error occurred! Code: 20210420004819c3dc7aa5
immunohistochemistry
Oops, an error occurred! Code: 20210420004819b7f77774
ion channels
Oops, an error occurred! Code: 202104200048193bc55aa2
photoreceptors
Oops, an error occurred! Code: 202104200048192777c166
retinal degenerations: cell biology
Oops, an error occurred! Code: 2021042000481937f743eb
retinitis pigmentosa
Oops, an error occurred! Code: 2021042000481914ebb1a7
second messengers: pharmacology/physiology
Oops, an error occurred! Code: 20210420004819e869347c
signal transduction: pharmacology/physiology
Oops, an error occurred! Code: 20210420004819a9964e48
ion channels
Oops, an error occurred! Code: 2021042000481966c3fb88
genetic mouse models
Oops, an error occurred! Code: 2021042000481951c32240
viral gene transfer
Oops, an error occurred! Code: 20210420004819a7bd8613
retinal signaling pathways
Oops, an error occurred! Code: 20210420004819120a0af3
retinal degeneration
Oops, an error occurred! Code: 2021042000481905e0a4f5