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Center for Integrated Protein Science Munich - Pharmacology

We are studying the role of ion channels in retinal function and diseases. To this end we use a variety of technologies including electrophysiology, imaging, immunohistochemistry as well genetic mouse models.

Our particular focus is on cyclic nucleotide-gated (CNG) and voltage-gated calcium channels.

We have generated a number of genetic mouse models to investigate the physiological roles of these proteins in vivo. Using these mouse models we are also studying the molecular basis of photoreceptor degeneration in cone dystrophies and retinitis pigmentosa.

Finally, we have established viral transfection systems (based on AAV and lentiviral vectors) to rescue retinal function in murine retina.

Methodology

  • Mouse models
  • Electrophysiology – Calcium imaging
  • Immunohistochemistry
  • Viral gene transfer (AAV, lentiviral vectors)

Scientific Cooperations

Group Leader

Martin Biel
[more information]

Contact

Center for Integrated Protein Science Munich CIPSM and
Department of Pharmacy – Center for Drug Research

Butenandtstr. 5-1381377 MunichGermany

Phone: +49-89-2180-77327
Fax-Number: +49-89-2180-77326

Email:
mbiel[at]cup.uni-muenchen.de

Website:
www.cup.uni-muenchen.de/dept/ph/pharmakologie/biel.php

Current Research Projects

  • Project 1:
    Functional rescue of CNG channels  in genetic mouse models
  • Project 2:
    Analysis of signaling pathways linked to rod and cone photoreceptor degeneration
  • Project 3:
    Identification of molecular mechanisms of CNG channel targeting in photoreceptors
  • Project 4:
    Functional analysis of Cav1.4 in retinal circuits
  • Project 5:
    Orphan ion channels in retina

Research Groups

People

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degenerations/dystrophies
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electroretinography: non-clinical
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gene transfer/gene therapy
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immunohistochemistry
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ion channels
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photoreceptors
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retinal degenerations: cell biology
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second messengers: pharmacology/physiology
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signal transduction: pharmacology/physiology
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ion channels
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genetic mouse models
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viral gene transfer
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retinal signaling pathways
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retinal degeneration
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