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Enrique De la Rosa

Short CV

1981 Ms. Sc. Universidad Autónoma de Madrid
1984 Ph. D. Universidad Autónoma de Madrid. Centro de Biología Molecular, CSIC-UAM
Post-doctoral positions: 
1984-1985 Centro de Biología Molecular, CSIC-UAM
1986-1989 Max-Planck Institute for Developmental Biology, Tübingen (Germany), under Alexander-von-Humboldt Foundation Program
1989-1992 Instituto Cajal, CSIC
1992-1993 Centro de Investigaciones Biológicas, CSIC
Staff scientist:
1993 Científico Titular, Centro de Investigaciones Biológicas, CSIC
2002 promoted to Investigador Científico, Centro de Biología Molecular, CSIC-UAM
Visiting Scientist: 
1993 Developmental Endocrinology Branch, NIH, Bethesda (USA)
2003 Wilmer Eye Institute, Johns Hopkins University, Baltimore (USA)

Scientifc Interest

  • To understand the functional basis of programmed cell death during retinal/neural development.
  • To understand the role of DNA repair during retinal/neural development.
  • To attenuate the progression of retinal dystrophies.
  • To understand subtle molecular and celular changes associated to retinal aging.

Memberships

  • Association for Research in Vision and Ophthalmology (ARVO)
  • SfN

Spanish Societies

  • SENC,
  • SEBC,
  • SEBD,
  • SEBBM

 

 

Enrique De la Rosa
Enrique De la Rosa

Research Group

3D Lab (Development, Differentiation and Degeneration)

[more information]

Contact

Centro de Investigaciones Biológicas

Consejo Superior de Investigaciones Científicas

C/ Ramiro de Maeztu 9
E-28040 Madrid
Spain

Phone: 34/918373112, ext 4375
FAX: 34/915360432

Email:
ejdelarosa[at]cib.csic.es

Website
http://www.cib.csic.es

Key Publications

  1. DNA-PK promotes the survival of young neurons in the embryonic mouse retina.
    J. Baleriola, T. Suárez and , E.J. de la Rosa (2010)
    Cell Death Differ 17, 1697-1706.
  2. The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium.
    M.A. Mellén, E. J. de la Rosa and P. Boya (2008).
    Cell Death Differ  15,1279-1290 .
  3. Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.
    T. Chavarría, A. I. Valenciano, R. Mayordomo, J. Egea, J. X. Comella, F. Hallböök, F. de Pablo and E. J. de la Rosa (2007).
    Dev. Neurobiol. 67, 1777-1788.
  4. Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina.
    A. I. Valenciano, S. Corrochano, F. de Pablo, P. de la Villa and E. J. de la Rosa (2006).
    J. Neurochem 99, 524-536.
  5. Balance of pro-apoptotic TGF-β and anti-apoptotic insulin effects in the control of cell death in the developing mouse retina.
    N. Duenker, A. I. Valenciano, A. Franke, C. Hernández-Sánchez, R. Dressel, M. Behrendt, F. de Pablo, K. Krieglstein and E. J. de la Rosa (2005).
    Eur. J. Neurosci 22, 28-38.
  6. IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.
    A. I. Arroba, D. Wallace, A. Mackey, E. J. de la Rosa# and T. G. Cotter# (#, contributing equally) (2009) Eur J Neurosci 30, 975-986.
  7. Vimentin isoform expression in the human retina characterized with the monoclonal antibody 3CB2.
    M. J. Pérez-Álvarez, C. Isiegas, C. Santano, J. J. Salazar, A. I. Ramírez, A. Triviño, J. M. Ramírez, J. P. Albar, E. J. de la Rosa and C. Prada (2008).
    J Neurosci Res 86, 1871-1883.
  8. Functional and structural modifications during retinal degeneration in the rd10 mouse.
    R. Barhoum, G. Martínez-Navarrete, S. Corrochano, F. Germain, L. Fernández-Sánchez, E. J. de la Rosa, P. de la Villa and N. Cuenca (2008). Neuroscience 155, 698-713.
  9. Apoptosis in the trabecular meshwork of glaucomatous patients.
    J. Baleriola, J. García-Feijoo, J. M. Martínez-de-la-Casa, A. Fernández-Cruz, E. J. de la Rosa# and R. Fernández-Durango# (#, contributing equally) (2008).
    Mol Vis 14:1513-1516.
  10. Proinsulin attenuates the loss of vision and delays apoptosis of photoreceptors in a mouse model of retinitis pigmentosa.
    S. Corrochano, R. Barhoum, P. Boya, A. I. Arroba, N. Rodríguez-Muela, V. Gómez-Vicente, F. Bosch, F. de Pablo, P. de la Villa and E. J. de la Rosa (2008).
    Invest Invest Ophthalmol Vis Sci  49, 4188-4194.

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