Shinya Yamanaka, who won a share of the 2012 Nobel Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application (CiRA) in Japan over a fraudulent paper published by center researchers. But observers in Japan say Yamanaka, who was not an author of the paper, was simply emphasizing how seriously he takes scientific misconduct.