You are here: vision-research.eu » People » Research Groups » Germany » Langmann, Thomas

Retinal Immunity

Our group aims at understanding the molecular events leading to microglial activation and microgliosis in inherited retinal degeneration.

We are using microglia-specific reporter mice and several mouse models of retinal degeneration to define distinct phenotypes of activated microglia. We envision a microglia-targeted neuroprotective therapy by converting neurotoxic microglial populations into homeostatic cells. Immunomodulatory bioactive compounds including the Omega-3-fatty acid docosahexaenoic acid (DHA) and Luteolin are currently tested for their microglia-deactivating potential.

In a collaboration with Carlo Rivolta (Lausanne)and Andreas Gal (Hamburg) we have recently identified nonsense mutations in the FAM161A gene leading to autosomal recessive Retinitis Pigmentosa. A major task for the future will be to characterize the biological functions of FAM161A and to define the molecular events leading to retinal degeneration in the absence of FAM161A.

We are further interested to define the cis-regulatory architecture of photoreceptors as a basis for retina-specific gene expression. Together with Joseph Corbo (St. Louis) we characterize the transcriptional network orchestrated by the transcription factor CRX (Cone-rod homeobox).

Group Leader

Thomas Langmann
[more information]

Contact

University of Regensburg

Institute of Human Genetics
Franz-Josef-Strauss Allee 11
93053 Regensburg
Germany

Phone: +49 (0) 941-944-5423
Fax: +49 (0) 941-944-5402

E-mail:
thomas.langmann[at]klinik.uni-regensburg.de

Website:
http://www-huge.uni-regensburg.de/Forschung/AG_Langmann/AG_Langmann.shtml

Methodology

  • Microglia reporter and retinal degeneration mice
  • In situ and ex vivo analyses, retinal explants, cell cultures
  • Immune-based methods and molecular genetics

Scientific Cooperations

  • Cooperation 1
    Prof. Joseph Corbo (St. Louis)
  • Cooperation 2
    Prof. Rudolf Martini (Würzburg)
  • Cooperation 3
    Prof. David Hume (Edinburgh)
  • Cooperation 4
    Prof. Anand Swaroop (NIH, NEI)
  • Cooperation 5
    Prof. Robin Ali, Dr. Ulrich Luhmann (London)

Current Research Projects

  • Project 1
    Microglial activation in retinal degeneration
  • Project 2
    Role of FAM161A in photoreceptor function and disease
  • Project 3
    Crx-directed cis-regulatory architecture of photoreceptors

Research Groups

People

Related Research Groups

microglia
Oops, an error occurred! Code: 2021012000183938e96ffe
photoreceptors
Oops, an error occurred! Code: 20210120001839399c3541
retinal culture
Oops, an error occurred! Code: 20210120001839b25f9ea0
retinal degenerations: cell biology
Oops, an error occurred! Code: 202101200018393b480194
retinal degenerations: hereditary
Oops, an error occurred! Code: 20210120001839572417ea
retinitis pigmentosa
Oops, an error occurred! Code: 20210120001839eb3f4ad2
transcription factors
Oops, an error occurred! Code: 20210120001839c02c28da
transgenics/knock-outs
Oops, an error occurred! Code: 20210120001839c9752204
inherited retinal degeneration
Oops, an error occurred! Code: 202101200018398bc78d73
Crx
Oops, an error occurred! Code: 202101200018395191f7ab
FAM161A
Oops, an error occurred! Code: 202101200018391fbb7a9f