You are here: vision-research.eu » People » Research Groups » Germany » Langmann, Thomas

Retinal Immunity

Our group aims at understanding the molecular events leading to microglial activation and microgliosis in inherited retinal degeneration.

We are using microglia-specific reporter mice and several mouse models of retinal degeneration to define distinct phenotypes of activated microglia. We envision a microglia-targeted neuroprotective therapy by converting neurotoxic microglial populations into homeostatic cells. Immunomodulatory bioactive compounds including the Omega-3-fatty acid docosahexaenoic acid (DHA) and Luteolin are currently tested for their microglia-deactivating potential.

In a collaboration with Carlo Rivolta (Lausanne)and Andreas Gal (Hamburg) we have recently identified nonsense mutations in the FAM161A gene leading to autosomal recessive Retinitis Pigmentosa. A major task for the future will be to characterize the biological functions of FAM161A and to define the molecular events leading to retinal degeneration in the absence of FAM161A.

We are further interested to define the cis-regulatory architecture of photoreceptors as a basis for retina-specific gene expression. Together with Joseph Corbo (St. Louis) we characterize the transcriptional network orchestrated by the transcription factor CRX (Cone-rod homeobox).

Group Leader

Thomas Langmann
[more information]

Contact

University of Regensburg

Institute of Human Genetics
Franz-Josef-Strauss Allee 11
93053 Regensburg
Germany

Phone: +49 (0) 941-944-5423
Fax: +49 (0) 941-944-5402

E-mail:
thomas.langmann[at]klinik.uni-regensburg.de

Website:
http://www-huge.uni-regensburg.de/Forschung/AG_Langmann/AG_Langmann.shtml

Methodology

  • Microglia reporter and retinal degeneration mice
  • In situ and ex vivo analyses, retinal explants, cell cultures
  • Immune-based methods and molecular genetics

Scientific Cooperations

  • Cooperation 1
    Prof. Joseph Corbo (St. Louis)
  • Cooperation 2
    Prof. Rudolf Martini (Würzburg)
  • Cooperation 3
    Prof. David Hume (Edinburgh)
  • Cooperation 4
    Prof. Anand Swaroop (NIH, NEI)
  • Cooperation 5
    Prof. Robin Ali, Dr. Ulrich Luhmann (London)

Current Research Projects

  • Project 1
    Microglial activation in retinal degeneration
  • Project 2
    Role of FAM161A in photoreceptor function and disease
  • Project 3
    Crx-directed cis-regulatory architecture of photoreceptors

Research Groups

People

Related Research Groups

microglia
De la Rosa, Enrique
Heiduschka, Peter
Limb, Astrid
Sennlaub, Florian
Sørensen, Torben Lykke
Xu, Heping
photoreceptors
Ader, Marius
Arango-Gonzalez, Blanca
Arden, Geoffrey
Artal, Pablo
Auricchio, Alberto
Baraas, Rigmor
Berendschot, Tos
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Bujakowska, Kinga
Cangiano, Lorenzo
Chadderton, Naomi
Cottet, Sandra
Dell'Orco, Daniele
Ekström, Per
Goureau, Olivier
Heiduschka, Peter
Hicks, David
Julien, Sylvie
Kamermans, Maarten
Kawasaki, Aki
Kennedy, Breandan
Kremers, Jan
Larsen, Michael
MacLaren, Robert
Marigo, Valeria
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Strettoi, Enrica
Ueffing, Marius
van Veen, Theo
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Zeitz, Christina
retinal culture
Ader, Marius
Arango-Gonzalez, Blanca
Ekström, Per
Goureau, Olivier
Grus, Franz
Kustermann, Stefan
Martin, Keith
Paquet-Durand, Francois
Pastor, Jose-Carlos
Picaud, Serge
Reichenbach, Andreas
Sennlaub, Florian
Tsilimbaris, Miltiadis
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Thanos, Solon
van Veen, Theo
Wolfrum, Uwe
retinal degenerations: cell biology
Arango-Gonzalez, Blanca
Arden, Geoffrey
Audo, Isabelle
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Cordeiro, M Francesca
Ekström, Per
Enzmann, Volker
Greenwood, John
Grimm, Christian
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Johnsen-Soriano, Siv
Karl, Mike O.
Kennedy, Breandan
Kustermann, Stefan
Lengyel, Imre
Marigo, Valeria
Martin, Keith
Palfi, Arpad
Paquet-Durand, Francois
Picaud, Serge
Reichenbach, Andreas
Stitt, Alan
Sennlaub, Florian
Tsilimbaris, Miltiadis
Roepman, Ronald
Sancho-Pelluz, Javier
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
Strettoi, Enrica
Sørensen, Torben Lykke
Thanos, Solon
Ueffing, Marius
Weber, Bernhard
Wijnholds, Jan
Wolfrum, Uwe
retinal degenerations: hereditary
Arden, Geoffrey
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Banfi, Sandro
Baraas, Rigmor
Bergen, Arthur
Bhattacharya, Shomi
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cottet, Sandra
Cremers, Frans
den Hollander, Anneke
Ekström, Per
Graw, Jochen
Hamel, Christian ✝
Inglehearn, Chris
Kennedy, Breandan
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Petersen, Michael
Tsilimbaris, Miltiadis
Rivolta, Carlo
Roepman, Ronald
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Schimpf-Linzenbold, Simone
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
van Veen, Theo
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
Wright, Alan
Zrenner, Eberhart
retinitis pigmentosa
Ader, Marius
Arango-Gonzalez, Blanca
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Bergen, Arthur
Berger, Wolfgang
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cremers, Frans
De la Rosa, Enrique
den Hollander, Anneke
Dollfus, Hélène
Enzmann, Volker
Fighting Blindness
Griciuc, Ana
Hamel, Christian ✝
Larsen, Michael
MacLaren, Robert
Moore, Tony
Palfi, Arpad
Paquet-Durand, Francois
Tsilimbaris, Miltiadis
Rivolta, Carlo
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Seeliger, Mathias
van Veen, Theo
Wijnholds, Jan
Wolfrum, Uwe
Wright, Alan
Zrenner, Eberhart
transcription factors
Banfi, Sandro
Bovolenta, Paola
Goureau, Olivier
Grimm, Christian
Hicks, David
Kennedy, Breandan
Paquet-Durand, Francois
Vignali, Roberto
Weber, Bernhard
transgenics/knock-outs
Bovolenta, Paola
Bujakowska, Kinga
Hindges, Robert
Humphries, Peter
Kennedy, Breandan
Lucas, Robert
Roepman, Ronald
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
inherited retinal degeneration
Auricchio, Alberto
Cottet, Sandra
Crx
FAM161A

Missing some information on vision-research.eu?

* mandatory field