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Naomi Chadderton

Current Research Projects

My primary research interest is the exploration of mutation independent gene therapeutic approaches for inherited retinal degenerations, particularly autosomal dominant Retinitis Pigmentosa (adRP) and Leber’s hereditary optic neuropathy (LHON). 

Methodology

  • Adeno-associated virus  (production, purification and delivery),
  • RNAi-based gene suppression,
  • Gene expression,
  • Cell and molecular biology,
  • In vivo models of retinal disease,
  • Morphological and functional analyses

Selected Publications

  1. Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P.
    Protection of Photoreceptors in a Mouse Model of RP10.
    Adv Exp Med Biol. 2010;664:559-65.
  2. McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ.
    AAV-mediated chronic over-expression of SNAP25 in adult rat doral hippocampus impairs memory-associated synaptic plasticity.
    J Neurochem. 2010 Feb;112(4):991-1004.
  3. Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Li T, Wolfrum U, Humphries P, Kenna PF, Farrar GJ.
    Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
    Hum Gene Ther. 2010 Mar;21(3):311-23.
  4. Chadderton N, Millington-Ward S, Palfi A, O'Reilly M, Tuohy G, Humphries M, Li T, Humphries P, Kenna PF, Farrar GJ.
    Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.
    Mol Ther. 2009 Apr;17(4):593-9.
  5. Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P.
    Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in murine model of autosomal dominant retinitis pigmentosa (RP10).
    Hum Mol Genet. 2008 Jul 15;17(14):2084-100.
  6. O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ.
    A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
    Vision Res. 2008 Feb;48(3):386-91.
  7. O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ.
    RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
    Am J Hum Genet. 2007 Jul;81(1):127-35.
  8. Chadderton N, Cowen RL, Sheppard FC, Robinson S, Greco O, Scott SD, Stratford IJ, Patterson AV, Williams KJ.
    Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.
    Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):213-22.
  9. Chadderton NS, Stringer SE.
    Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparin sulphate.
    Int J Biochem Cell Biol. 2003 Jul;35(7):1052-5.

Research Group

Ocular Genetic

Contact

Trinity College Dublin

Smurfit Institute of Genetics

Dublin 2
Dublin
Ireland

Phone: 00353 1 896 2482
Fax: 00353 1 896 3848

E-mail:
chaddern[at]tcd.ie

Website:
www.tcd.ie

Documents

CV of Naomi Chadderton [pdf]

Research Groups

People

Related Research Groups

adenovirus
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ganglion cells
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gene/expression
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gene transfer/gene therapy
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growth factors/growth factor receptors
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neuroprotection
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photoreceptors
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retinal degenerations: hereditary
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retinitis pigmentosa
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