You are here: » People » Young Researcher » Chadderton, Naomi

Naomi Chadderton

Current Research Projects

My primary research interest is the exploration of mutation independent gene therapeutic approaches for inherited retinal degenerations, particularly autosomal dominant Retinitis Pigmentosa (adRP) and Leber’s hereditary optic neuropathy (LHON). 


  • Adeno-associated virus  (production, purification and delivery),
  • RNAi-based gene suppression,
  • Gene expression,
  • Cell and molecular biology,
  • In vivo models of retinal disease,
  • Morphological and functional analyses

Selected Publications

  1. Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P.
    Protection of Photoreceptors in a Mouse Model of RP10.
    Adv Exp Med Biol. 2010;664:559-65.
  2. McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ.
    AAV-mediated chronic over-expression of SNAP25 in adult rat doral hippocampus impairs memory-associated synaptic plasticity.
    J Neurochem. 2010 Feb;112(4):991-1004.
  3. Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Li T, Wolfrum U, Humphries P, Kenna PF, Farrar GJ.
    Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
    Hum Gene Ther. 2010 Mar;21(3):311-23.
  4. Chadderton N, Millington-Ward S, Palfi A, O'Reilly M, Tuohy G, Humphries M, Li T, Humphries P, Kenna PF, Farrar GJ.
    Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.
    Mol Ther. 2009 Apr;17(4):593-9.
  5. Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P.
    Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in murine model of autosomal dominant retinitis pigmentosa (RP10).
    Hum Mol Genet. 2008 Jul 15;17(14):2084-100.
  6. O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ.
    A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
    Vision Res. 2008 Feb;48(3):386-91.
  7. O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ.
    RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
    Am J Hum Genet. 2007 Jul;81(1):127-35.
  8. Chadderton N, Cowen RL, Sheppard FC, Robinson S, Greco O, Scott SD, Stratford IJ, Patterson AV, Williams KJ.
    Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.
    Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):213-22.
  9. Chadderton NS, Stringer SE.
    Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparin sulphate.
    Int J Biochem Cell Biol. 2003 Jul;35(7):1052-5.

Research Group

Ocular Genetic


Trinity College Dublin

Smurfit Institute of Genetics

Dublin 2

Phone: 00353 1 896 2482
Fax: 00353 1 896 3848




CV of Naomi Chadderton [pdf]

Research Groups


Related Research Groups

Oops, an error occurred! Code: 20190216002823ba1ca27a
ganglion cells
Oops, an error occurred! Code: 201902160028239caa2c42
Oops, an error occurred! Code: 20190216002823edd3efc0
gene transfer/gene therapy
Oops, an error occurred! Code: 20190216002823b193c363
growth factors/growth factor receptors
Oops, an error occurred! Code: 201902160028232da544db
Oops, an error occurred! Code: 201902160028237d5a7329
Oops, an error occurred! Code: 201902160028232f62c7cd
retinal degenerations: hereditary
Oops, an error occurred! Code: 2019021600282387264815
retinitis pigmentosa
Oops, an error occurred! Code: 2019021600282300f39913