You are here: vision-research.eu » People » Young Researcher » Chadderton, Naomi

Naomi Chadderton

Current Research Projects

My primary research interest is the exploration of mutation independent gene therapeutic approaches for inherited retinal degenerations, particularly autosomal dominant Retinitis Pigmentosa (adRP) and Leber’s hereditary optic neuropathy (LHON). 

Methodology

  • Adeno-associated virus  (production, purification and delivery),
  • RNAi-based gene suppression,
  • Gene expression,
  • Cell and molecular biology,
  • In vivo models of retinal disease,
  • Morphological and functional analyses

Selected Publications

  1. Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P.
    Protection of Photoreceptors in a Mouse Model of RP10.
    Adv Exp Med Biol. 2010;664:559-65.
  2. McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ.
    AAV-mediated chronic over-expression of SNAP25 in adult rat doral hippocampus impairs memory-associated synaptic plasticity.
    J Neurochem. 2010 Feb;112(4):991-1004.
  3. Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Li T, Wolfrum U, Humphries P, Kenna PF, Farrar GJ.
    Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
    Hum Gene Ther. 2010 Mar;21(3):311-23.
  4. Chadderton N, Millington-Ward S, Palfi A, O'Reilly M, Tuohy G, Humphries M, Li T, Humphries P, Kenna PF, Farrar GJ.
    Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.
    Mol Ther. 2009 Apr;17(4):593-9.
  5. Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P.
    Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in murine model of autosomal dominant retinitis pigmentosa (RP10).
    Hum Mol Genet. 2008 Jul 15;17(14):2084-100.
  6. O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ.
    A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
    Vision Res. 2008 Feb;48(3):386-91.
  7. O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ.
    RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
    Am J Hum Genet. 2007 Jul;81(1):127-35.
  8. Chadderton N, Cowen RL, Sheppard FC, Robinson S, Greco O, Scott SD, Stratford IJ, Patterson AV, Williams KJ.
    Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.
    Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):213-22.
  9. Chadderton NS, Stringer SE.
    Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparin sulphate.
    Int J Biochem Cell Biol. 2003 Jul;35(7):1052-5.

Research Group

Ocular Genetic

Contact

Trinity College Dublin

Smurfit Institute of Genetics

Dublin 2
Dublin
Ireland

Phone: 00353 1 896 2482
Fax: 00353 1 896 3848

E-mail:
chaddern[at]tcd.ie

Website:
www.tcd.ie

Documents

CV of Naomi Chadderton [pdf]

Research Groups

People

Related Research Groups

adenovirus
ganglion cells
Arden, Geoffrey
Bach, Michael
Bergen, Arthur
Bovolenta, Paola
Cordeiro, M Francesca
De la Rosa, Enrique
Dedek, Karin
Dedek, Karin
Guenther, Elke
Hicks, David
Hindges, Robert
Joachim, Stephanie
Kremers, Jan
Lagreze, Wolf
Limb, Astrid
Lucas, Robert
Martin, Keith
Naumann, Gottfried
Picaud, Serge
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Schimpf-Linzenbold, Simone
Strettoi, Enrica
Thanos, Solon
Vitanova, Liliya
Wissinger, Bernd
gene/expression
Banfi, Sandro
Bergen, Arthur
Bovolenta, Paola
Bujakowska, Kinga
Butterworth, Jacqueline
Chakravarthy, Usha
Coupland, Sarah
Dollfus, Hélène
Goureau, Olivier
Grau, Tanja
Graw, Jochen
Grimm, Christian
Guggenheim, Jez
Hamel, Christian ✝
Humphries, Peter
Kennedy, Breandan
Krishnakumar, Arjun
Lengyel, Imre
O'Driscoll, Ciara
Palfi, Arpad
Rivolta, Carlo
Roska, Botond
Schaeffel, Frank
Tassignon, Marie-José
Topouzis, Fotis
van Heyningen, Veronica
Zeitz, Christina
gene transfer/gene therapy
Auricchio, Alberto
Bhattacharya, Shomi
Biel, Martin
Bujakowska, Kinga
Calonge, Margarita
Goureau, Olivier
Hamel, Christian ✝
Kustermann, Stefan
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
Martin, Keith
Palfi, Arpad
Roska, Botond
Seeliger, Mathias
Stieger, Knut
Wijnholds, Jan
Wolfrum, Uwe
growth factors/growth factor receptors
Arango-Gonzalez, Blanca
Bovolenta, Paola
Cordeiro, M Francesca
De la Rosa, Enrique
Griciuc, Ana
Grimm, Christian
Hicks, David
Krishnakumar, Arjun
Lütjen-Drecoll, Elke
Strauss, Olaf
Ueffing, Marius
van Veen, Theo
neuroprotection
Andrés-Guerrero, Vanessa
Arango-Gonzalez, Blanca
Auricchio, Alberto
Cordeiro, M Francesca
Cottet, Sandra
Ekström, Per
Enzmann, Volker
Grimm, Christian
Grus, Franz
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Humphries, Peter
Joachim, Stephanie
Karl, Mike O.
Kremers, Jan
Kustermann, Stefan
Lagreze, Wolf
Martin, Keith
Miranda Sanz, María
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Scanlon, Peter
Skorkovská, Karolína
Ueffing, Marius
van Veen, Theo
Zrenner, Eberhart
photoreceptors
Ader, Marius
Arango-Gonzalez, Blanca
Arden, Geoffrey
Artal, Pablo
Auricchio, Alberto
Baraas, Rigmor
Berendschot, Tos
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Bujakowska, Kinga
Cangiano, Lorenzo
Cottet, Sandra
Dell'Orco, Daniele
Ekström, Per
Goureau, Olivier
Heiduschka, Peter
Hicks, David
Julien, Sylvie
Kamermans, Maarten
Kawasaki, Aki
Kennedy, Breandan
Kremers, Jan
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Marigo, Valeria
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Strettoi, Enrica
Ueffing, Marius
van Veen, Theo
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Zeitz, Christina
retinal degenerations: hereditary
Arden, Geoffrey
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Banfi, Sandro
Baraas, Rigmor
Bergen, Arthur
Bhattacharya, Shomi
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Cottet, Sandra
Cremers, Frans
den Hollander, Anneke
Ekström, Per
Graw, Jochen
Hamel, Christian ✝
Inglehearn, Chris
Kennedy, Breandan
Langmann, Thomas
Lorenz, Birgit
Lotery, Andrew John
MacLaren, Robert
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Petersen, Michael
Tsilimbaris, Miltiadis
Rivolta, Carlo
Roepman, Ronald
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Schimpf-Linzenbold, Simone
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
van Veen, Theo
Weber, Bernhard
Wijnholds, Jan
Wissinger, Bernd
Wright, Alan
Zrenner, Eberhart
retinitis pigmentosa
Ader, Marius
Arango-Gonzalez, Blanca
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Bergen, Arthur
Berger, Wolfgang
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Cremers, Frans
De la Rosa, Enrique
den Hollander, Anneke
Dollfus, Hélène
Enzmann, Volker
Fighting Blindness
Griciuc, Ana
Hamel, Christian ✝
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Moore, Tony
Palfi, Arpad
Paquet-Durand, Francois
Tsilimbaris, Miltiadis
Rivolta, Carlo
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Seeliger, Mathias
van Veen, Theo
Wijnholds, Jan
Wolfrum, Uwe
Wright, Alan
Zrenner, Eberhart

Missing some information on vision-research.eu?

* mandatory field