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MacLaren Research Group

The main focus of our research is on retinal repair and regeneration, using with either gene therapy or stem cell approaches. We are also running several clinical trials for retinal diseases, including a gene therapy trial to treat choroideraemia.

Current Research Projects

  • Project 1
    Photoreceptor transplantation using a stem cell approach
  • Project 2
    Development of improved AAV vector capsids
  • Project 3
    Gene replacement strategies for future RP clinical trials
  • Project 4
    Gene and cell based strategies for neuroprotection
  • Project 5
    RPE-choroid transplantation surgery for AMD

Methodology

  • Gene therapy with AAV,
  • Animal models of retinal disease,
  • Imaging techniques,
  • Electrophysiology,
  • Vitreoretinal surgery,

Scientific Cooperations

  • Cooperation 1
    Prof Miguel Seabra, Imperial College London
  • Cooperation 2
    Prof Eberhart Zrenner, University of Tübingen
  • Cooperation 3
    Prof Peter Charbel Issa, University of Bonn

Group Leader

Robert MacLaren
[more information]

Contact

University of Oxford

Nuffield Laboratory of Ophthalmology

Level 6 West Wing
John Radcliffe Hospital
Headley Way
OX3 9DU
Oxford
United Kingdom

Phone: 01865 234796

E-mail:
Enquiries[at]eye.ox.ac.uk

Website:
www.eye.ox.ac.uk

Research Groups

People

Related Research Groups

choroid
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gene transfer/gene therapy
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genetics
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photoreceptors
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retinal degenerations: hereditary
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retinal pigment epithelium
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retinitis pigmentosa
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transplantation
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vitreoretinal surgery
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