You are here: vision-research.eu » People » Research Groups » Italy » Cangiano, Lorenzo

Research Group of Lorenzo Cangiano

My lab explores the functional properties of mammalian rod and cone photoreceptors using the mouse retina as a model system. Our current focus is on the strength and regulatory potential of connexin–mediated electrical coupling between rods and cones, which we investigate by peforming patch–clamp recordings from single mouse cones. Using this technique we are able to compare light responses and membrane currents of the same neuron in different mouse strains, as well as observe the changes evoked by acute pharmacological manipulation.

Methodology

  • Patch clamp recordings of rods, cones and bipolar cells in slices of the dark–adapted mouse retina.

Current Research Projects

  • Project 1:
    Functional latitude and regulation of gap junctional coupling between mouse photoreceptors
  • Project 2:
    Light response properties of mouse rods and cones

Scientific Cooperations

  • Cooperation 1:
    Claudia Gargini, Università di Pisa
  • Cooperation 2:
    Daniele Dell'Orco, University of Verona
  • Cooperation 3:
    Sten Grillner, Karolinska Institute

Group Leader

Lorenzo Cangiano
[more information]

Contact

Università di Pisa

Dip. di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia

Via San Zeno 31
56123 Pisa
Italy

Phone: +390502213498
FAX: +390502213527

Email:
lorenzo.cangiano[at]gmail.com

Website:
http://retina.farm.unipi.it/lorenzo.cangiano.html

Research Groups

People

Related Research Groups

bipolar cells
Oops, an error occurred! Code: 20200926011935d62b93cc
electrophysiology: non-clinical
Oops, an error occurred! Code: 2020092601193581b4c337
gap junctions/coupling
Oops, an error occurred! Code: 20200926011935de8f93a9
photoreceptors
Oops, an error occurred! Code: 20200926011935b49185be
ion channels
Oops, an error occurred! Code: 2020092601193547529b9c
photoreceptors: visual performance
Oops, an error occurred! Code: 20200926011935e1b4f8d3
retina: distal (photoreceptors, horizontal cells, bipolar cells)
Oops, an error occurred! Code: 2020092601193594010024
retinal connections, networks, circuitry
Oops, an error occurred! Code: 20200926011935d41d633d
mouse retina
Oops, an error occurred! Code: 202009260119350551435e
rods
Oops, an error occurred! Code: 20200926011935094bcf35
cones
Oops, an error occurred! Code: 20200926011935e1edf8ce
patch-clamp
Oops, an error occurred! Code: 20200926011935e1891429
gap junctions
Oops, an error occurred! Code: 2020092601193512df7649