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Research Group of Lorenzo Cangiano

My lab explores the functional properties of mammalian rod and cone photoreceptors using the mouse retina as a model system. Our current focus is on the strength and regulatory potential of connexin–mediated electrical coupling between rods and cones, which we investigate by peforming patch–clamp recordings from single mouse cones. Using this technique we are able to compare light responses and membrane currents of the same neuron in different mouse strains, as well as observe the changes evoked by acute pharmacological manipulation.

Methodology

  • Patch clamp recordings of rods, cones and bipolar cells in slices of the dark–adapted mouse retina.

Current Research Projects

  • Project 1:
    Functional latitude and regulation of gap junctional coupling between mouse photoreceptors
  • Project 2:
    Light response properties of mouse rods and cones

Scientific Cooperations

  • Cooperation 1:
    Claudia Gargini, Università di Pisa
  • Cooperation 2:
    Daniele Dell'Orco, University of Verona
  • Cooperation 3:
    Sten Grillner, Karolinska Institute

Group Leader

Lorenzo Cangiano
[more information]

Contact

Università di Pisa

Dip. di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia

Via San Zeno 31
56123 Pisa
Italy

Phone: +390502213498
FAX: +390502213527

Email:
lorenzo.cangiano[at]gmail.com

Website:
http://retina.farm.unipi.it/lorenzo.cangiano.html

Research Groups

People

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bipolar cells
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electrophysiology: non-clinical
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gap junctions/coupling
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photoreceptors
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ion channels
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photoreceptors: visual performance
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retina: distal (photoreceptors, horizontal cells, bipolar cells)
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retinal connections, networks, circuitry
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mouse retina
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rods
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cones
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patch-clamp
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gap junctions
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