- Normal and pathological aging of the retina
- Age related macular degeneration
- Genomics and proteomics of zinc nutrition
- Biochemical basis of sub-RPE deposit formation
- Genotype and phenotype of peripheral pathologies.
- Biochemical Society
- Association for Research in Vision and Ophthalmology (ARVO)
- Royal Society of Medicine
- International Society for Neurochemistry
Imre Lengyel |
Research Group
Ocular Biology and Therapeutics
Key Publications
- Sallo, F.B., Bereczki E., Csont, T., Luthert, P.J., Munro, P., Ferdinandy, P., Sántha, M. and Lengyel, I.:
Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes.
(2009) Exp Eye Res. 89(2):178-186 - Nan, R., Gor, J., Lengyel, I. and Perkins, S.J.,:
Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator Factor H and its possible implications for function and disease.
(2008) J Mol Biol. 384(5):1341-1352 - I. Lengyel and Peto T:
Cure or cause: the opposing roles for zinc in age-related macular degeneration
(2008) Expert Rev Ophthal. 3 1-4 - I. Lengyel, Flinn, J.M, Peto T, Linkous, D.H, Cano, K, Bird A.C, Lanzirotti A, Frederickson C.J. and van Kuijk F.J.G.M:
High concentration of zinc in sub-retinal pigment epithelial deposits
(2007) Exp Eye Res. 84 772-780 (see news coverage: news.bbc.co.uk/1/hi/health/6457427.stm) - I. Lengyel, R. Thomas, C.J. Frederickson and T. Pető (2006)
Zinc and age-related macular degeneration In Trace Elements in the Food Chain
Eds: M, Szilagyi, K. Szentmihalyi.
Publisher: Hungarian Academy of Sciences, ISBN 963 7067 132, pages: 411-415 - I. Lengyel, A. Tufail, H. Al-Hossain, P. Luthert, A. Bird and G. Jeffery:
The association of drusen deposition with capillary walls in the aging human eye
(2004) Invest Ophthalmol Vis Sci. 45 2886–2892 - Zs. Molnar, P. Kovács, I. Lazckó, K. Soós, L. Fülöp, B. Penke and I. Lengyel:
Enhanced G-protein activation by a mixture of Aß(25-35), Aß(1-40/42) and zinc
(2004) J Neurochem 89 1215–1223 - J. Xue, X. Wang, M. Kinoshita, P.J. Milburn, I. Lengyel, J.A.P. Rostas, P.J. Robinson:
Phosphorylation of a new brain-specific septin, G-septin, by cyclic GMP-dependent protein kinase.
(2000) J Biol Chem, 275, 10047-10056 - I. Lengyel, S. Fieuw-Makaroff, A.L. Hall, A.T.R. Sim, J.A.P. Rostas, P.R. Dunkley:
Modulation of the activity of Calcium/Calmodulin-stimulated protein kinase II by zinc.
(2000) J Neurochem 75, 594605. - I. Lengyel, L.E. Olesen, K.A. Nichol, K.L. Brain, P.J. Robinson, X. Wang, M.R. Bennett and J.A.P. Rostas (1999)
Protein phosphorylation in chick ciliary ganglion under conditions that induce long lasting change in synaptic transmission: phosphoprotein targets for nitric oxide action.
Neuroscience, 90, 607-619
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